Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines

PHASE1CompletedINTERVENTIONAL
Enrollment

226

Participants

Timeline

Start Date

March 26, 2021

Primary Completion Date

February 17, 2023

Study Completion Date

February 17, 2023

Conditions
Poliomyelitis
Interventions
BIOLOGICAL

Novel Oral Polio Vaccine Type 1 (nOPV1)

Each 0.1 mL (2 drops) dose of vaccine contains approximately 10\^6.5 CCID50.

BIOLOGICAL

Novel Oral Polio Vaccine Type 3 (nOPV3)

Each 0.1 mL (2 drops) dose of vaccine contains approximately 10\^6.5 CCID50.

BIOLOGICAL

Sabin Monovalent Oral Polio Vaccine Type 1 (mOPV1)

The Sabin mOPV1 control vaccine contains ≥ 10\^6.0 CCID50 per 0.1 mL (2 drops) dose.

BIOLOGICAL

Sabin Monovalent Oral Polio Vaccine Type 3 (mOPV3)

the Sabin mOPV3 control vaccine contains ≥ 10\^5.8 CCID50 per 0.1 mL (2 drops) dose.

Trial Locations (4)

21201

Pharmaron CPC, Inc., Baltimore

03756

Dartmouth Hitchcock Medical Center, Lebanon

27599-7215

University of North Carolina Institute for Global Health and Infectious Diseases (IGHID), Chapel Hill

05405

University of Vermont Vaccine Testing Center, Burlington

All Listed Sponsors
collaborator

Bill and Melinda Gates Foundation

OTHER

collaborator

Centers for Disease Control and Prevention

FED

collaborator

Viroclinics Biosciences B.V.

INDUSTRY

collaborator

The Emmes Company, LLC

INDUSTRY

lead

PATH

OTHER

NCT04529538 - Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines | Biotech Hunter | Biotech Hunter