960
Participants
Start Date
October 31, 2020
Primary Completion Date
September 30, 2022
Study Completion Date
September 30, 2022
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors)
Patients will be treated with one kind of selective serotonin reuptake inhibitors/ serotonin and norepinephrine reuptake inhibitors. Dose is titrated to the minimum effective dose within 2 weeks. Benzodiazepines can be used for a short period lasting no more than 2 weeks.
Treatment as Usual
The research doctor discusses the treatment plan with the patient, and therapies and drugs are not limited.
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors) Combined with Magnetic Stimulations
Drug therapies are the same as the SSRIs/SNRIs monotherapy group. Patients will randomly receive one kind of magnetic stimulations including repetitive transcranial magnetic stimulation (rTMS), continuous theta burst stimulation(cTBS) and intermittent theta burst stimulation (iTBS) at a ratio of 1:1:1.
Huashan Hospital, Fudan University, Shanghai
Med-X Research Institute of Shanghai Jiao Tong University, Shanghai
Renji Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai
Shanghai Tenth People's Hospital, Tongji University, Shanghai
Collaborators (1)
RenJi Hospital
OTHER
Shanghai 10th People's Hospital
OTHER
Huashan Hospital
OTHER
Shanghai Jiao Tong University School of Medicine
OTHER
Nanjing Medical University
OTHER
Zhejiang University
OTHER
Shanghai Mental Health Center
OTHER