Study of Sacituzumab Govitecan Versus Physician's Choice of Treatment in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread

PHASE3CompletedINTERVENTIONAL
Enrollment

712

Participants

Timeline

Start Date

January 13, 2021

Primary Completion Date

July 4, 2025

Study Completion Date

July 4, 2025

Conditions
Locally Advanced or Metastatic Unresectable Urothelial Cancer
Interventions
DRUG

Sacituzumab Govitecan-hziy

Administered intravenously

DRUG

Paclitaxel

Administered intravenously

DRUG

Docetaxel

Administered intravenously

DRUG

Vinflunine

Administered intravenously

Trial Locations (234)

0

Prince of Wales Hospital, Hong Kong

100

National Taiwan University Hospital, Taipei

333

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan District

613

Chiayi Chang Gung Memorial Hospital, Buzi

813

Kaohsiung Veterans General Hospital, Kaohsiung City

833

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

1020

Krankenhaus Der Barmherzigen Bruder Wien, Vienna

1100

Charité Universitätsmedizin Berlin - Campus Benjamin Franklin, Wien

1205

Hôpitaux Universitaires de Genève, Geneva

1233

Specialized Hospital for Active Treatment of Oncological Diseases - Sofia District, Sofia

2109

Chris O'Brien Lifehouse, North Ryde

2145

Westmead Hospital, Westmead

2298

Calvary Mater Newcastle, Waratah

3000

Peter MacCallum Cancer Centre, Melbourne

Universitair Ziekenhuis Leuven, Leuven

3010

University of Bern, Bern

3021

Sunshine Hospital, Saint Albans

3084

Austin Health, Heidelberg

3168

Monash Health, Clayton

4010

Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz

4051

University Hospital Basel, Basel

4066

Icon Cancer Centre Wesley, Auchenflower

5000

Centro Hospitalar de Tras-os-Montes e Alto Douro, Vila Real

5037

Ashford Cancer Centre Research - ICON Cancer Centre Adelaide, Kurralta Park

5042

Southern Adelaide Local Health Network Incorporated, Bedford Park

5800

Multiprofile Hospital for Active Treatment Heart and Brain EAD, Pleven

6000

Grand Hôpital De Charleroi - Notre Dame, Charleroi

High Technology Hospital MedCenter, Batumi

6009

Liverpool Hospital, Nedlands

Sir Charles Gairdner Hospital, Nedlands

6230

Hacettepe Universitesi Tip Fakultesi- Kanser Enstitusu, Ankara

6500

Istituto Oncologico Della Svizzera Italiana (IOSI), Bellinzona

6620

Cebeci Hastanesi, Mamak

7001

ICON Cancer Centre Hobart, Hobart

8036

Universitätsklinik für Innere Medizin Graz, Graz

Hospital Clinic de Barcelona, Barcelona

8091

Universitaetsspital Zurich - Klinik fur Medizinische Onkologie und Hematologie, Zurich

9000

Az Maria Middelares Ghent, Ghent

Universitair Ziekenhuis Gent, Ghent

10000

"Clinical Hospital Centre Sestre Milosrdnice", Zagreb

10043

Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Torino

10060

Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia, Candiolo (TO)

10065

Weill Cornell Medical College, New York

10408

National Cancer Center, Goyang-si

10467

Montefiore Medical Center, The Bronx

11217

Taipei Veterans General Hospital, Taipei

11528

Alexandra General Hospital, Athens

13620

Seoul National University Bundang Hospital, Seongnam-si

14004

Hospital Reina Sofia, Córdoba

14076

Centre Francois Baclesse, Caen

14263

Roswell Park Cancer Institute, Buffalo

16132

Ospedale Policlinico San Martino, Genova

16247

The Catholic University of Korea Saint Vincent's Hospital, Suwon

17033

Penn State Hershey Cancer Institute, Hershey

20010

MedStar Washington Hospital Center, Washington D.C.

20132

Ospedale San Raffaele, Milan

21000

Clinical Hospital Centre Split, Split

Centre Georges- Francois Leclerc, Dijon

21201

University of Maryland School of Medicine, Baltimore

22030

Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi, Edirne

22763

Asklepios Klinik Altona, Hamburg

23100

Ospedale Civile Di Sondrio, Sondrio

26332

University Hospital of Patras, Pátrai

28007

Hospital General Universitario Gregorio Maranon, Madrid

28027

Clínica Universidad de Navarra - Madrid, Madrid

28033

MD Anderson Cancer Center, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28100

Azienda Ospedaliero Universitaria Maggiore Della Carita, Novara

28222

Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda

29200

Centre Hospiltalier Universitaire Brest - Hôpital Morvan, Brest

30029

Centre Hospitalier Universitaire de Nimes, Nîmes

31008

Clinica Universidad de Navarra, Pamplona

31059

Institut Claudius Regaud, Toulouse

32005

Complexo Hospitalario de Ourense (CHOU), Ourense

32207

Baptist MD Anderson Cancer Center, Jacksonville

33075

CHU Saint Andre, Bordeaux

33081

Centro di Riferimento Oncologico di Aviano, Aviano

33322

Boca Raton Clinical Research Global USA - Plantation, Plantation

34090

Institut Régional du Cancer de Montpellier ICM Val d' Aurelle, Montpellier

34214

Bagcilar Medipol Mega Universite Hastanesi, Istanbul

34365

VKV Amerikan Hastanesi Department of Oncology, Şişli

34457

Istanbul Acibadem University Maslak Hospital, Istanbul

34722

T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul

35015

Chungnam National University Hospital, Daejeon

35042

Centre Eugene Marquis, Rennes

35575

Medical Park Izmır Hastanesi, Izmir

35760

Centre Hospitalier Privé Saint-Grégoire, Saint-Grégoire

36213

Álvaro Cunqueiro Hospital, Vigo

37126

Azienda Ospedaliera Universitaria Integrata Verona, Verona

37916

Thompson Oncology Group - Knoxville Downtown, Knoxville

37920

University Cancer Specialists - Knoxville, Knoxville

38122

Ospedale di Trento - Presidio Ospedaliero Santa Chiara, Trento

39008

Hospital Universitario Marqués de Valdecilla, Santander

40447

China Medical University Hospital, Taichung

41013

Hospital Universitario Virgen del Rocio, Seville

44195

Cleveland Clinic, Cleveland

44281

Meir Medical Center, Kfar Saba

45147

Universitätsklinikum Essen, Essen

45332

University Hospital Of Ioannina, Ioannina

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

48149

Universitatsklinikum Munster, Münster

49241

Pusan National University Hospital, Busan

50612

Pusan National University Yangsan Hospital, Gyeongsangnam-do

52100

Ospedale San Donato, Arezzo

52242

University of Iowa Hospitals and Clinics, Iowa City

52621

Chaim Sheba Medical Center, Tel Litwinsky

54623

Anassa General Clinic, Thessaloniki

56068

Institut Für Versorgungsforschung in Der Onkologie, Koblenz

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

59000

Centre Oscar Lambret, Lille

60389

Centrum fur Hamatologie und Onkologie Bethanien, Frankfurt am Main

63011

Centre Jean Perrin, Clermont-Ferrand

67091

Les Hôpitaux Universitaires de Strasbourg, Strasbourg

69373

Centre Leon Berard, Lyon

70124

Istituto Tumori Bari Giovanni Paolo II - IRCCS, Bari

70403

National Cheng Kung University Hospital, Tainan City

72076

Universitätsklinikum Tübingen, Tübingen

72622

Studienpraxis Urologie, Nürtingen

74104

Oklahoma Cancer Specialists and Research Institute (OCSRI), Tulsa

75015

Hôpital Européen Georges-Pompidou, Paris

75390

Harold C. Simmons Comprehensive Cancer Center, Dallas

76104

Center for Cancer and Blood Disorders, Fort Worth

81352

Regional University General Hospital of Herakleio, Crete, Herakleio

85054

Mayo Clinic - Arizona, Phoenix

90095

UCLA Hematology/ Oncology, Los Angeles

91054

Malteser Waldkrankenhaus Erlangen, Erlangen

91120

Hadassah University Hospital Ein Kerem, Jerusalem

92150

Hôpital Foch, Suresnes

92868

University of California Irvine (UCIMC), Orange

94805

Institut Gustave Roussy, Villejuif

98109

Seattle Cancer Care Alliance (SCCA), Seattle

99208

Summit Cancer Centers, Spokane

100034

Peking University First Hospital, Beijing

100039

Chinese People's Liberation Army General Hospital - 301 Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

100730

Chinese Academy of Medical Sciences Cancer Hospital, Beijing

110042

Liaoning Cancer Hospital and Institute, Shenyang

119074

National University Hospital, Singapore

130021

1st Hospital Jilin University, Changchun

210008

Nanjing Drum Tower Hospital, Nanjing

217562

Icon Cancer Centre Farrer Park, Singapore

230031

Anhui Provincial Cancer Hospital, Hefei

231405

Taipei Tzu Chi General Hospital, New Taipei City

250012

Qilu Hospital of Shandong University, Jinan

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

308433

Tan Tock Seng Hospital, Singapore

310014

Zhejiang Provincial People's Hospital - Zhaohui, Hangzhou

310022

Cancer Hospital of the University of Chinese Academy of Sciences Zhejiang Cancer Hospital, Hangzhou

325000

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

350001

Union Hospital of Fujian Medical University, Fuzhou

350005

The First Affiliated Hospital of Fujian Medical University, Fujian

400030

Chongqing University Cancer Hospital, Chongqing

410013

Hunan Cancer Hospital - Xiangya Hospital - Central South University, Changsha

430030

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

510060

Sun Yat-Sen University Cancer Center, Guangzhou

610041

West China Hospital Sichuan University, Chengdu

610072

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu

830000

Affiliated Tumor Hospital of Xinjiang Medical University, Ürümqi

3109601

Rambam Health Care Campus, Haifa

4941492

Rabin Medical Center, Petah Tikva

6423906

Tel Aviv Medical Center (Ichilov Hospital), Tel Aviv

7030000

Shamir Medical Center (Assaf Harofeh), Be’er Ya‘aqov

02215

Beth Israel Deaconess Medical Center, Boston

B-4000

Centre Hospitalier Universitaire de Liège, Liège

T6G 1Z2

Cross Cancer Institute, Edmonton

B3H 2Y9

qeii health sciences centre - VG site, Halifax

L8V 5C2

Juravinski Hospital and Cancer Centre, Hamilton

N6A 4G5

London Health Sciences Centre, London

H3T 1E2

Jewish General Hospital, Montreal

H4A 3J1

McGill University Health Centre, Montreal

L1G 2B9

R.S. McLaughlin Durham Regional Cancer Centre, Oshawa

M5G 2M9

Princess Margaret Cancer Centre, Toronto

V5Z 4E6

British Columbia Cancer Agency-Vancouver Centre, Vancouver

Unknown

University Hospital Centre Zagreb, Zagreb

Ramsay Health Clinic Belharra, Bayonne

Queen Mary Hospital, Hong Kong

Hong Kong United Oncology Centre, Kowloon

Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E, Porto

775 20

Fakultni nemocnice Olomouc, Olomouc

120 00

Urocentrum Praha, Prague

85925 CEDEX 9

Centre Hospitalier Departemental Vendee, La Roche-sur-Yon

06189

Centre Antoine Lacassagne, Nice

0114

New Hospitals, Tbilisi

0144

L. Managadze National Center of Urology, Tbilisi

0160

Evex Medical corporation, Tbilisi

0167

Jerarsi Clinic, Tbilisi

01307

Universitatsklinik Dresden, Dresden

115 25

401 General Military Hospital of Athens, Athens

115 26

Henry Dunant Hospital, Athens

124 62

Attikon Hospital, Chaïdári

413 34

University Hospital of Larissa, Larissa

151 25

Athens Medical Center, Marousi

546 22

Bioclinic - Thessaloniki, Thessaloniki

546 39

Theagenio Anticancer Hospital of Thessaloniki, Thessaloniki

555 35

Interbalkan Medical Center of Thessaloniki, Thessaloniki

D24 NR0A

Tallaght University Hospital, Dublin

X91 ER8E

University Hospital Waterford, Waterford

00144

Istituto Regina Elena, Roma

00128

Università Campus Bio-Medico di Roma, Rome

05100

Azienda Ospedaliera Santa Maria di Terni, Terni

4710-243

Hospital de Braga, Braga

6300-858

Unidade Local de Saúde da Guarda - Hospital Sousa Martins, Guarda

2410-197

Centro Hospitalar de Leiria - Hospital de Santo André, Leiria

1649-035

Centro Hospitalar de Lisboa Norte - Hospital de Santa Maria, Lisbon

00907

BRCR Medical Center, Inc, San Juan

361-711

Chungbuk National University Hospital, Cheongju-si

405-760

Gachon University Gil Medical Center, Incheon

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

137-040

The Catholic University of Korea Seoul Saint Mary's Hospital, Seoul

08003

Hospital del Mar - Parc de Salut, Barcelona

08035

Hospital Universitari Vall D'Hebron, Barcelona

08243

Hospital Sant Joan de Déu de Manresa, Manresa

553 05

Länssjukhuset Ryhov, Jönköping

581 85

Universitetssjukhuset i Linköping, Linköping

171 76

Karolinska Universitetssjukhuset - Solna, Stockholm

Taiwan 407

Taichung Veterans General Hospital, Taichung

B15 2WB

University Hospitals Birmingham NHS Foundation Trust, Birmingham

DT1 2JY

Dorset County Hospital NHS Foundation Trust, Dorchester

G12 0YN

NHS Greater Glasgow and Clyde, Glasgow

EC1A 7BE

Barts Health NHS Trust, London

SE1 9RT

Guys and Saint Thomas NHS Foundation Trust, Guy's Hospital, London

W1G 6AD

Sarah Cannon Research Institute London, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

HA6 2RN

East and North Hertfordshire NHS Trust, Middlesex

OX3 7LE

Oxford University Hospitals NHS Foundation Trust, Oxford

SA12 7BR

Swansea Bay University Health Board, Port Talbot

PR2 9HT

Royal Preston Hospital, Preston

SM2 5PT

The Royal Marsden NHS Foundation Trust, Surrey

WV10 0QP

The Royal Wolverhampton NHS Trust, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY