A Dose-Ranging Study With Vupanorsen (TRANSLATE-TIMI 70)

PHASE2CompletedINTERVENTIONAL
Enrollment

286

Participants

Timeline

Start Date

September 28, 2020

Primary Completion Date

September 29, 2021

Study Completion Date

December 6, 2021

Conditions
DyslipidemiasHyperlipidemiasHyperlipoproteinemias
Interventions
DRUG

Vupanorsen

Vupanorsen and placebo will be provided as prefilled syringes packaged and dispensed in cartons with tamper-evident seals. Only single-use syringes will be used.

DRUG

Placebo

Vupanorsen and placebo will be provided as prefilled syringes packaged and dispensed in cartons with tamper-evident seals. Only single-use syringes will be used.

Trial Locations (114)

12110

ImageCare Latham, Latham

12211

Capital Cardiology Associates, Albany

19104

Hospital of the University of Pennsylvania, Philadelphia

Perelman Center for Advanced Medicine, Hospital of the University of Pennsylvania, Philadelphia

21229

Maryland Cardiovascular Specialists, Baltimore

Seton Imaging Center, Baltimore

23294

National Clinical Research, Inc., Richmond

27103

PMG Research of Winston-Salem, LLC, Winston-Salem

27203

Randolph Health Internal Medicine, Asheboro

27205

Randolph Health MRI Center, Asheboro

27518

PMG Research of Raleigh, LLC d/b/a PMG Research of Cary, Cary

Wake Radiology, Cary

27609

Accellacare - Raleigh, Raleigh

PMG Research of Raleigh, LLC, Raleigh

Wake Radiology Diagnostic Imaging Inc, Raleigh

29118

Clermont Radiology Orangeburg, Orangeburg

South Carolina Clinical Research LLC, Orangeburg

32086

St Johns Center for Clinical Research, Saint Augustine

32205

Westside Center for Clinical Research, Jacksonville

32256

Borland-Groover Clinic, Jacksonville

Precision Imaging Centers, Jacksonville

32277

Care Partners Clinical Research, LLC, Jacksonville

32819

Sand Lakes Imaging, Orlando

33511

Tower Radiology Parsons, Brandon

Tower Radiology, Brandon

33756

Innovative Research of West Florida, Inc., Clearwater

33880

Clinical Research of Central Florida, Winter Haven

34653

Advanced Research Institute, Inc., New Port Richey

37388

Tennessee Center for Clinical Trials, Tullahoma

Tullahoma HMA, LLC d\b\a Tennova HealthCare Harton, Tullahoma

40213

L-MARC Research Center, Louisville

40222

Heartland Imaging, Louisville

45224

Hightop Medical Research Center, Cincinnati

45229

Imaging Research Center-Cincinnati Children's, Cincinnati

55101

Regions Hospital - HealthPartners, Saint Paul

67042

Alliance for Multispecialty Research, LLC, El Dorado

Susan B. Allen Memorial Hospital, El Dorado

72205

CARTI, Little Rock

72209

Atria Clinical Research, Little Rock

75230

Dallas Diabetes Research Center, Dallas

75231

Southwest Diagnostic Imaging Center, Dallas

77030

SimonMed Houston, Houston

77074

Southwest Clinical Trials, Houston

79761

Medical Center Hospital, Odessa

Permian Research Foundation, Odessa

84121

J. Lewis Research, Inc. / Foothill Family Clinic South, Salt Lake City

85295

Horizon Clinical Research Associates, PLLC, Gilbert

85297

Scottsdale Medical Imaging Research, LLC, Gilbert

89014

Viable Research Management LLC, Henderson

89074

Pueblo Medical Imaging, Henderson

92705

West Coast Radiology, Santa Ana

92780

University Clinical Investigators, Inc., Tustin

95648

Clinical Trials Research, Lincoln

95825

Diagnostic Radiological Imaging, Sacramento

98057

Rainier Clinical Research Center, Renton

98166

Bellevue Medical Imaging, Seattle

98405

Universal Research Group, LLC, Tacoma

01805

Lahey Clinic Hospital and Medical Center, Burlington

01830

Pentucket Medical Associates, Haverhill

T6H 2L4

C-endo, Edmonton

T6J 5E5

MIC Medical Imaging, Edmonton

T8H 0N2

Synergy Medical Clinic, Sherwood Park

V3S 9A5

Access MRI, Surrey

V3V 0C6

SMH Cardiology Clinical Trials Inc., Surrey

B3H 1V7

Nova Scotia Health Authority QE II Health Sciences Centre, Halifax

B3H 2Y9

Nova Scotia Health Authority QE II Health Sciences Centre, Halifax

L4N 7L3

LMC Clinical Research Inc. (Barrie), Barrie

L6T 0G1

Aggarwal and Associates Limited, Brampton

L4K 4M2

LMC Clinical Research Inc. (Thornhill), Concord

M9R 4E1

LMC Clinical Research Inc. (Etobicoke), Etobicoke

N1H 1B1

Dawson Clinical Research, Guelph

N2M 5N4

KMH Cardiology Centres Inc., Kitchener

N5W 6A2

Milestone Research Inc., London

N6A 5B7

Robarts Research Institute, Western University, London

L5R 3K6

GNMI Medical Imaging, Mississauga

L5R 3K7

GNMI Medical Imaging, Mississauga

L6R 3K7

GNMI MRI and CT Medical Imaging, Mississauga

M6B 3H7

North York Diagnostic and Cardiac Centre, North York

N7T 4X3

Bluewater Clinical Research Group Inc., Sarnia

M4G 1R8

Holland Bloorview Kids Rehabilitation Hospital, Toronto

M9V 4B4

Dr. Anil K. Gupta Medicine Professional Corporation, Toronto

N4S 5P5

Devonshire Clinical Research Inc., Woodstock

G7H 4J1

Resonance Magnetique du Saguenay-Lac-Saint-Jean, Chicoutimi

G7H 7K9

Ecogene-21, Chicoutimi

J7J 2K8

Manna Research (Mirabel), Mirabel

H1M 1B1

Recherche GCP Research, Montreal

H1T 1C8

Montreal Heart Institute, Montreal

H4A 3J1

Research Institute of the McGill University Health Center, Montreal

Research Institute of the McGill University Health Centre, Montreal

H9R 4R9

Radimed West Island, Pointe-Claire

J6E 2B4

Diex Recherche Joliette, Saint-Charles-Borromée

G1J 0H4

IRM Quebec - Complexe Synase, Québec

IRM Quebec Synase, Québec

G1N 4V3

Diex Recherche Quebec Inc., Québec

G1W4R4

Centre de Recherche Saint-Louis, Québec

G2J 0C4

Alpha Recherche Clinique, Québec

15-402

NZOZ Kendron, Bialystok

15-879

ClinicMed Daniluk, Nowak Spolka Jawna, Bialystok

32-500

Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow, Chrzanów

80-546

Centrum Badan Klinicznych PI-House sp. z o.o., Gdansk

81-366

Centrum Medyczne Enel-Med., Oddzial Alfa Plaza - Gdynia, Gdynia

40-555

Kardio Brynow, Katowice

40-752

"Niepubliczny Zaklad Opieki Zdrowotnej TERAPIA OPTIMA", Katowice

40-760

HELIMED Katowice - Rezonans Magnetyczny, Tomografia Komputerowa (MRI), Katowice

HELIMED Katowice - Rezonans Magnetyczny, Tomografia Komputerowa, Katowice

20-857

"TWOJA PRZYCHODNIA Sp. z o.o.", Lublin

20-883

Top Medical Lublin, Lublin

60-589

Centrum Zdrowia Metabolicznego Pawel Bogdanski, Poznan

62-041

Arterieart Sp. z o.o., Puszczykowo

43-100

SZPITAL SW. ELZBIETY W KATOWICACH Polsko-Amerykanskie Kliniki Serca, Tychy

50-088

Futuremeds, Wroclaw

50-450

Skanmex (MRI), Wroclaw

51-685

Wro Medica, Wroclaw

53-234

TOMMA Pracownia rezonansu magnetycznego we Wroclawiu, Wroclaw

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

The TIMI Study Group

OTHER

lead

Pfizer

INDUSTRY