A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)

PHASE3CompletedINTERVENTIONAL
Enrollment

829

Participants

Timeline

Start Date

August 24, 2020

Primary Completion Date

May 27, 2025

Study Completion Date

July 31, 2025

Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
DRUG

Atezolizumab

Atezolizumab 1680 mg every 4 weeks (Q4W) will be administered IV on Day 1 of each 28-day cycle.

DRUG

Tiragolumab

Tiragolumab 840 mg Q4W will be administered IV on Day 1 of each 28-day cycle.

DRUG

Durvalumab

Durvalumab will be administered based on weight at 10 mg/kg IV every 2 weeks (Q2W) on Days 1 and 15 of each 28-day cycle, or will be administered at a fixed dose of 1500 mg IV every 4 weeks (Q4W) (for participants whose weight \>/= 30 kg) on Day 1 of each 28-day cycle.

Trial Locations (177)

112

Taipei Veterans General Hospital, Taipei

1023

Auckland City Hospital, Cancer and Blood Research, Auckland

1140

Klinik Penzing, Vienna

2045

Tudogyogyintezet Torokbalint, Törökbálint

2148

Blacktown Hospital, Blacktown

2217

St George Hospital, Kogarah

2560

Macarthur Cancer Therapy Centre, Campbelltown

2800

Szent Borbala Korhaz, Tatabánya

3168

Monash Health Translational Precinct, Victoria

3500

Jessa Zkh (Campus Virga Jesse), Hasselt

4020

Kepler Universitätskliniken GmbH - Med Campus III, Linz

5042

Flinders Medical Centre, Bedford Park

6000

GHdC Site Les Viviers, Charleroi

6020

Tiroler Landeskrankenanstalten Ges.M.B.H., Innsbruck

6149

Fiona Stanley Hospital, Bull Creek

7623

Pécsi Tudományegyetem, Pécs

9000

AZ Maria Middelares, Ghent

10029

Mount Sinai Medical Center, New York

10300

Vajira Hospital, Bangkok

10400

Rajavithi Hospital, Bangkok

Ramathibodi Hospital;Medicine/Oncology, Bangkok

10408

National Cancer Center, Gyeonggi-do

10461

Montefiore Medical Center, The Bronx

11527

Sotiria Hospital, Athens

12002

Hospital Provincial de Castellon, Castellon

12208

New York Oncology Hematology,P.C.-Albany, Albany

13015

Hopital Nord AP-HM, Marseille

13620

Seoul National University Bundang Hospital, Gyeonggi-do

14000

Centre Francois Baclesse, Caen

15006

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

16132

IRCCS AOU San Martino - IST, Genoa

16247

St. Vincent's Hospital, Gyeonggi-do

16499

Ajou University Medical Center, Gyeonggi-do

21280

Dicle University Faculty of Medicine, Diyarbakır

21565

Gachon University Gil Medical Center, Incheon

22030

Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi, Edirne

22031

Virginia Cancer Specialists, Fairfax

23502

Virginia Oncology Associates, Norfolk

25123

A.O. Spedali Civili Di Brescia-P.O. Spedali Civili, Brescia

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

28009

Hospital General Universitario Gregorio Marañon, Madrid

28046

Hospital Universitario La Paz, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

29010

Hospital Regional Universitario Carlos Haya, Málaga

29615

Prisma Health ? Upstate, Greenville

30060

Northwest Georgia Oncology Centers PC - Marietta, Marietta

32503

Woodlands Medical Specialists, P.A., Pensacola

32901

Cancer Care Centers of Brevard, Palm Bay

33705

Florida Cancer Specialist, North Region, St. Petersburg

34070

Clinique Clémentville, Montpellier

34098

Istanbul University Cerrahpasa Faculty of Medicine, Istanbul

34214

Medipol University Medical Faculty, Istanbul

35100

Ege University Medical Faculty, Bornova, ?zm?r

36100

Azienda ULSS 8 Berica, Vicenza

37203

Sarah Cannon Research Institute / Tennessee Oncology, Nashville

37403

Tennessee Oncology Chattanooga, Chattanooga

38114

Klinikum Braunschweig, Braunschweig

40447

China Medical University Hospital, Taichung

41013

Hospital Universitario Virgen del Rocio, Seville

41404

Kyungpook National University Chilgok Hospital, Daegu

43100

Azienda Ospedaliero Universitaria di Parma, Parma

44033

Ulsan University Hosiptal, Ulsan

44280

Inonu University Faculty of Medicine Turgut Ozal Medical Center, Malatya

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola

49933

CHU Angers, Angers

50612

Pusan National University Yangsan Hospital, Gyeongsangnam-do

51109

Klinikum Koeln-Merheim, Cologne

55404

Minnesota Oncology Hematology, Minneapolis

56124

Azienda Ospedaliera Universitaria Pisana - Ospedale Cisanello, Pisa

57070

Hopital Robert Schuman, Vantoux

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

61615

Illinois Cancer Care, Peoria

64132

HCA Midwest Health, Kansas City

65807

Cox Health Systems, Springfield

69126

Thoraxklinik Heidelberg gGmbH, Heidelberg

80131

Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Napoli

80631

Banner MD Anderson Cancer Center, Greeley

87401

San Juan Oncology Associates, Farmington

89106

Optum Health Care, Las Vegas

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

90110

Songklanagarind Hospital, Songkhla

93053

Universitätsklinikum Regensburg, Regensburg

94305

Stanford University, Palo Alto

94805

Institut Gustave Roussy, Villejuif

100142

Beijing Cancer Center, Beijing

101149

Beijing Chest Hospital, Beijing

200000

Shanghai Chest Hospital, Shanghai

210009

Zhongda Hospital Affiliated to Southeast University, Nanjing

221000

The Affiliated Hospital of Xuzhou Medical College, Xuzhou

250117

Shandong Cancer Hospital, Jinan

266042

The affiliated hospital of Qingdao university, Qingdao

300060

Tianjin Cancer Hospital, Tianjin

310002

Hangzhou Cancer Hospital, Hangzhou

325000

The 2nd School of Medicine, WMU, Wenzhou

350001

Fujian Medical University Union Hospital, Fujian

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400030

Chongqing Cancer Hospital, Chongqing

410008

Xiangya Hospital Central South University, Changsha

450008

Henan Cancer Hospital, Zhengzhou

510060

Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou

515041

Cancer Hospital of Shantou University Medical College, Shantou

610041

Sichuan Provincial Cancer Hospital, Chengdu

3109601

Rambam Medical Center, Haifa

4941492

Rabin Medical Center, Petah Tikva

8410100

Soroka Medical Center, Beersheba

9103102

Shaare Zedek Medical Center, Jerusalem

33901-8101

Florida Cancer Specialists, Fort Myers

04011

New England Cancer Specialists, Brunswick

02719

Southcoast Health System, Fairhaven

08816

Titan Health Partners LLC, d/b/a Astera Cancer Care, East Brunswick

C1431FWO

CEMIC, Buenos Aires

C1284AEB

Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires

X5004FHP

Clinica Universitaria Reina Fabiola, Córdoba

S2000QGB

Sanatorio Parque S.A., Rosario

60336-550

Crio - Centro Regional Integrado de Oncologia, Fortaleza

80810-050

Centro Integrado de Oncologia de Curitiba, Curitiba

98700-000

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

14784-400

Hospital de Cancer de Barretos, Barretos

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

V2S 0C2

BC Cancer ? Abbotsford, Abbotsford

V8R 6V5

BC Cancer - Victoria, Victoria

L4M 6M2

Royal Victoria Regional Health Centre, Barrie

L6R 3J7

William Osler Health System Brampton Civic Hospital, Brampton

K1H 8L6

Ottawa Hospital Research Institute, Ottawa

030013

Shanxi Provincial Cancer Hospital, Taiyuan

570 10

"General Hospital G.Papanikolaou", Asvestochóri

145 64

Agioi Anargyroi Cancer Hospital, Kifissia

DUMMY_VALUE

Princess Margaret Hospital, Oncology, Hong Kong

Queen Elizabeth Hospital, Hong Kong

Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda), Milan

Unknown

Pamela Youde Nethersole Eastern Hospital, Hong Kong

Tuen Mun Hospital, Hong Kong

00128

Policlinico Universitario Campus Biomedico, Rome

00144

IRCCS Istituto Regina Elena (IFO), Rome

464-8681

Aichi Cancer Center, Aichi

277-8577

National Cancer Center East, Chiba

670-8520

National Hospital Organization Himeji Medical Center, Hyōgo

252-0375

Kitasato University Hospital, Kanagawa

606-8507

Kyoto University Hospital, Kyoto

981-0914

Sendai Kousei Hospital, Miyagi

951-8566

Niigata Cancer Center Hospital, Niigata

589-8511

Kindai University Hospital, Osaka

362-0806

Saitama Cancer Center, Saitama

411-8777

Shizuoka Cancer Center, Shizuoka

104-0045

National Cancer Center Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

641-8510

Wakayama Medical University Hospital, Wakayama

3813 TZ

Meander Medisch Centrum, Amersfoort

4819 EV

Amphia Ziekenhuis, Breda

2262 BA

Medisch Centrum Haaglanden, locatie Antoniushove, Leidschendam

6162 BG

Zuyderland Medisch Centrum - Sittard Geleen, Sittard-Geleen

80-214

Uniwersyteckie Centrum Kliniczne, Gda?sk

10-228

Szpital Kliniczny MSWiA z Warmi?sko-Mazurskim Centrum Onkologii, Olsztyn

05-400

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock

02-781

Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad, Warsaw

53-413

Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii, Wroc?aw

3000-075

IPO de Coimbra, Coimbra

1500-650

Hospital da Luz, Lisbon

4100-180

Hospital CUF Porto, Porto

4200-072

IPO do Porto, Porto

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

07198

Hospital Son Llatzer, Palma de Mallorca

08916

Hospital Universitari Germans Trias i Pujol, Badalona

08035

Hospital Universitari Vall d'Hebron, Barcelona

01220

Adana Baskent University Medical Faculty, Adana

06100

Ankara University Medical Faculty, Ankara

Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara

06500

Gazi University Medical Faculty, Oncology Hospital, Ankara

B9 5SS

Birmingham Heartlands Hospital, Birmingham

CB2 0QQ

Addenbrooke's NHS Trust, Cambridge

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

M20 4BX

Christie Foundation Trust, Manchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04513925 - A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter