NCT04511039 - Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 8, 2021

Primary Completion Date

September 1, 2026

Study Completion Date

April 1, 2027

Conditions

Advanced Malignant Solid NeoplasmClinical Stage III Gastroesophageal Junction AdenocarcinomaClinical Stage IV Gastroesophageal Junction AdenocarcinomaClinical Stage IVA Gastroesophageal Junction AdenocarcinomaClinical Stage IVB Gastroesophageal Junction Adenocarcinoma ALocally Advanced Colorectal CarcinomaLocally Advanced Gastroesophageal Junction AdenocarcinomaMetastatic Colorectal AdenocarcinomaMetastatic Gastroesophageal Junction AdenocarcinomaPathologic Stage III Gastroesophageal Junction AdenocarcinomaPathologic Stage IIIA Gastroesophageal Junction AdenocarcinomaPathologic Stage IIIB Gastroesophageal Junction AdenocarcinomaPathologic Stage IV Gastroesophageal Junction AdenocarcinomaPathologic Stage IVA Gastroesophageal Junction AdenocarcinomaPathologic Stage IVB Gastroesophageal Junction AdenocarcinomaPostneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8Stage III Colorectal Cancer AJCC v8Stage IIIA Colorectal Cancer AJCC v8Stage IIIB Colorectal Cancer AJCC v8Stage IIIC Colorectal Cancer AJCC v8Stage IV Colorectal Cancer AJCC v8Stage IVA Colorectal Cancer AJCC v8Stage IVB Colorectal Cancer AJCC v8Stage IVC Colorectal Cancer AJCC v8

Interventions

DRUG

Trifluridine and Tipiracil Hydrochloride

Given PO

DRUG

Talazoparib Tosylate

Given PO

Trial Locations (1)

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo