Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

RecruitingOBSERVATIONAL
Enrollment

210

Participants

Timeline

Start Date

November 18, 2020

Primary Completion Date

December 1, 2029

Study Completion Date

December 1, 2029

Conditions
Cystic Fibrosis
Interventions
DRUG

Ivacaftor or elexacaftor/tezacaftor/ivacaftor

In Part B, approved CFTR modulator as prescribed at the discretion of the treating physician -not dictated by the BEGIN investigators

Trial Locations (35)

10032

RECRUITING

Children's Hospital of New York, New York

10595

RECRUITING

New York Medical College at Westchester Medical Center, Valhalla

13210

RECRUITING

SUNY Upstate Medical University, Syracuse

14203

RECRUITING

The Cystic Fibrosis Center of Western New York, Buffalo

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

RECRUITING

Hershey Medical Center Pennsylvania State University, Hershey

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

22903

RECRUITING

University of Virginia, Charlottesville

32207

RECRUITING

Nemours Children's Clinic, Jacksonville

32827

RECRUITING

The Nemours Children's Clinic - Orlando, Orlando

33136

RECRUITING

University of Miami, Miami

35233

RECRUITING

The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham

43205

RECRUITING

Nationwide Children's Hospital, Columbus

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48109

RECRUITING

University of Michigan, Michigan Medicine, Ann Arbor

49503

RECRUITING

Helen DeVos Children's Hospital, Grand Rapids

52242

RECRUITING

University of Iowa, Iowa City

53792

RECRUITING

University of Wisconsin, Madison

55404

RECRUITING

Children's Hospitals and Clinics of Minnesota, Minneapolis

55455

RECRUITING

The Minnesota Cystic Fibrosis Center, Minneapolis

63110

RECRUITING

St. Louis Children's Hospital, St Louis

64108

RECRUITING

Children's Mercy Kansas City, Kansas City

66160

RECRUITING

University of Kansas Medical Center, Kansas City

73104

RECRUITING

Oklahoma Cystic Fibrosis Center, Oklahoma City

75207

RECRUITING

University of Texas Southwestern / Children's Health, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

77030

RECRUITING

Baylor College of Medicine, Houston

80045

RECRUITING

Children's Hospital Colorado, Aurora

84113

RECRUITING

Primary Children's Cystic Fibrosis Center, Salt Lake City

94304

RECRUITING

Stanford University Medical Center, Palo Alto

97239

RECRUITING

Oregon Health Sciences University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

02115

RECRUITING

Boston Children's Hospital, Boston

05401

RECRUITING

Vermont Children's Hospital, Burlington

All Listed Sponsors
collaborator

Cystic Fibrosis Foundation

OTHER

collaborator

University of Washington

OTHER

collaborator

University of Alabama at Birmingham

OTHER

lead

Sonya Heltshe

OTHER