Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE

PHASE4CompletedINTERVENTIONAL
Enrollment

3,591

Participants

Timeline

Start Date

September 4, 2020

Primary Completion Date

August 31, 2023

Study Completion Date

January 26, 2024

Conditions
Covid19
Interventions
DRUG

theraputic heparin

increased dose of heparin above standard of care.

DRUG

prophylactic heparin

standard of care dose of heparin

DRUG

P2Y12

added P2Y12 inhibitor

DRUG

Crizanlizumab Injection

crizanlizumab injection

DRUG

SGLT2 inhibitor

sglt2 inhibitor

Trial Locations (101)

10010

VA New York Harbor Healthcare System, New York

10016

NYU Langone, New York

10029

Mt. Sinai Hospital, New York

10461

Jacobi Medical Center, The Bronx

Montefiore Medical Center, The Bronx

10595

Westchester Medical Center, Valhalla

12208

Albany Medical College, Albany

13210

SUNY Upstate University Hospital, Syracuse

14220

Mercy Hospital Buffalo, Buffalo

15260

UPMC Presbyterian, Pittsburgh

17033

Penn State Health Milton S. Hershey Medical Center, Hershey

17822

Geisinger Research, Danville

18901

Doylestown Cardiology Associates, Doylestown

19104

Hospital of the University of Pennsylvania, Philadelphia

19141

Temple University, Philadelphia

23229

HCA Henrico Doctors Hospital, Richmond

26506

West Virginia University CTR, Morgantown

27157

Wake Forest, Winston-Salem

27704

Duke University Hospital, Durham

30308

Emory, Atlanta

30310

Morehouse School of Medicine, Atlanta

32216

Memorial Hospital, Jacksonville

32608

University of Florida, Gainesville

33613

AdventHealth Tampa, Tampa

35233

University of Alabama, Birmingham

37203

Sarah Cannon and HCA Research Institute, Nashville

37207

Skyline Medical Center, Nashville

39216

University of Mississippi Medical Center, Jackson

43210

Ohio State Universtiy Wexner Medical Center, Columbus

43608

Mercy Health St Vincent Medical Center, Toledo

44109

The MetroHealth System, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44307

Cleveland Clinic Akron General, Akron

45219

University of Cincinnati Medical Center, Cincinnati

46202

Indiana University Health Methodist Hospital, Indianapolis

48109

University of Michigan, Ann Arbor

48201

Wayne State University, Detroit

53715

University of Wisconsin Hospital; Meriter Hospital (UW affiliated), Madison

55415

Hennepin County Medical Center, Minneapolis

60612

Cook County Health, Chicago

University of Illinois at Chicago Health (UIH), Chicago

60805

OSF Little Company of Mary Medical Center (OSF LCM), Evergreen Park

62226

Memorial Hospital, Belleville

63110

Washington University School of Medicine, ACCS Research, St Louis

66160

Kansas University Medical Center, Kansas City

70121

Ochsner Clinic Foundation, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

74104

Ascension St. John Clinical Research Institute, Tulsa

75390

University of Texas Southwestern Medical Center, Dallas

76104

Medical City Ft Worth, Fort Worth

76508

Baylor Scott and White Medical Center - Temple, Temple

78701

University of Texas at Austin, Austin

80401

Denver Health and Hospital Authority, Denver

81501

St. Mary's Hospital & Regional Medical Center, Grand Junction

85719

University of Arizona, Tucson

89102

University Medical Center of Southern Nevada, Las Vegas

90027

Kaiser Permanente Los Angeles, Los Angeles

90048

Smidt Heart Institute at Cedars-Sinai, Los Angeles

90095

Ronald Reagan UCLA Medical Center, Los Angeles

90502

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance

92103

UC San Diego Hillcrest, San Diego

92335

Kaiser Permanente Fontana, Fontana

94110

Zuckerberg San Francisco General Hospital, San Francisco

94143

UCSF San Francisco, San Francisco

94305

Stanford University Medical Center, Stanford

94410

Zuckerberg San Francisco General Hospital, San Francisco

96813

Queens Medical Center, Honolulu

97239

Oregon Health and Science University, Portland

98122

Swedish Hospital, Seattle

06105

Saint Francis Hospital and Medical Center, Hartford

02118

Boston University, Boston

02135

St Elizabeth's Medical Center, Brighton

01199

Baystate Medical Center, Springfield

01655

University of Massachusetts, Worcester

08103

Cooper Health, Camden

07631

Englewood Health, Englewood

07960

Atlantic Health System, Morristown

07103

Rutgers New Jersey Medical School, Newark

08240

AtlantiCare Regional Medical Center, Pomona

02903

Rhode Island Hospital, Providence

02906

The Miriam Hospital, Providence

Unknown

Hospital Universitario Sao Francisco de Assis, Bragança Paulista

União Brasileira de Educação e Assistência - Hospital São Lucas da PUCRS, Porto Alegre

Centro de Estudos Clínicos do Hospital Cárdio Pulmonar, Salvador

Fundação Faculdade Regional De Medicina De São José Do Rio Preto, São José do Rio Preto

Instituto Dante Pazzanese de Cardiologia, São Paulo

Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP-InCor-HCFMUSP, São Paulo

Azienda Ospedaliero Sant Anna e San Sebastiano, Caserta

Maria Cecilia Hospital , Cotignola, Ravenna, Cotignola

Università degli Studi di Ferrara, Ferrara, Ferrara

Azienda Ospedaliero -Universitaria Careggi, Florence

Policlinico di Napoli, Napoli, Napoli

AOU Policlinico di Palermo, Palermo, Palermo

ASL-1 Imperiese, Sanremo, Sanremo

Hospital Universitario A Coruna, A Coruña

Hospital Virgen del Mar, Almería

Hospital Arnau de Vilanova, Lleida

Hospital Universitario La Paz, Madrid

Hospital Universitario Ramon Y Cajal, Madrid

Hospital Clínico Universitario de Salamanca, Salamanca

Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Matthew Neal MD

OTHER

NCT04505774 - Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE | Biotech Hunter | Biotech Hunter