Plasticity Using Stimulation and Habit: A Pilot Open-label rTMS Study for MCI

NACompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

April 12, 2021

Primary Completion Date

June 29, 2022

Study Completion Date

July 27, 2022

Conditions
Mild Cognitive Impairment
Interventions
DEVICE

High-dose accelerated rTMS

A MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System will be utilized. All participants will receive open-label treatment for approximately eight, 3-minute sessions of intermittent theta burst rTMS on each of three days within an eight-day span. A single session = 600 pulses at 120% resting motor threshold (rMT), intermittent Theta Burst Stimulation (iTBS) triplets at 50 Hz for 2 seconds and repeated every 10 seconds for a total of 190 s to left dorsolateral prefrontal cortex. Total pulses = 14,400. To enable adherence and retention, the days do not need to be contiguous. Same day sessions will be separated by 10-15 minutes, but more accounting for participant comfort.

Trial Locations (1)

29425

Medical University of South Carolina, Charleston

All Listed Sponsors
collaborator

National Center of Neuromodulation for Rehabilitation

OTHER

lead

Medical University of South Carolina

OTHER