56
Participants
Start Date
January 13, 2021
Primary Completion Date
July 1, 2024
Study Completion Date
July 1, 2024
Fluconazole
"Fluconazole 50 mg/capsule or placebo, per os during 18 weeks :~* From W0 to W2 : 1 caps/ day~* From W2 to W4 : 1 or 2 caps/day~* From W4 to W6 : 1, 2 or 3 caps/day~* From W6 to W18 : 1, 2, 3 or 4 caps/day~The number of capsules to take will be determined by 24-hours calciuria results performed every 2 weeks during the titration period (W2, W4 and W6).~During the titration period, if 24-hours calciuria is \> 0.1 mmol/kg/day, fluconazole dose will be increased every 2 weeks to 50 mg per intake, with a maximum dose of 200 mg/day. If 24-hour calciuria is ≤ 0.1mmol/kg/day, fluconazole dose will remain stable.~After W6 and until the end of the study, the treatment dose will remain stable (stable period)."
Placebo
Placebo (1, 2, 3 or 4 pills to take daily during 18 weeks), same appearance to experimental drug
Hôpital Universitaire Necker, Paris
Service de Néphrologie Rhumatologie Dermatologie Pédiatrique, Bron
CHU de Dijon, Dijon
Hôpital Edouard Herriot, Lyon
APHM - CHU Conception, Marseille
CHR Metz-Thionville, Metz
CHU de Nantes, Nantes
APHP - Hôpital Européen Georges Pompidou HEGP, Paris
Hôpital Universitaire Necker-Enfants Malades, Paris
CHU Rennes Pontchaillou, Rennes
CHU de Strasbourg, hôpital de Hautepierre, Strasbourg
Hospices Civils de Lyon
OTHER