Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

866

Participants

Timeline

Start Date

July 24, 2020

Primary Completion Date

March 18, 2024

Study Completion Date

June 19, 2026

Conditions
Advanced or Metastatic Breast Cancer
Interventions
DRUG

Trastuzumab deruxtecan

Trastuzumab deruxtecan by intravenous infusion

DRUG

Capecitabine

Investigator's choice standard of care single agent chemotherapy; capecitabine tablets will be given orally.

DRUG

Paclitaxel

Investigator's choice standard of care single agent chemotherapy; paclitaxel by intravenous infusion.

DRUG

Nab-Paclitaxel

Investigator's choice standard of care single agent chemotherapy; nab-paclitaxel by intravenous infusion

Trial Locations (293)

235

Research Site, Taipei

333

Research Site, Taoyuan District

710

Research Site, Tainan City

1062

Research Site, Budapest

1070

Research Site, Anderlecht

1122

Research Site, Budapest

1145

Research Site, Budapest

1200

Research Site, Brussels

1280

Research Site, Ciudad de Buenos Aires

1414

Research Site, CABA

1900

Research Site, La Plata

2010

Research Site, Darlinghurst

2065

Research Site, St Leonards

2100

Research Site, Copenhagen Ø

2298

Research Site, Waratah

2650

Research Site, Edegem

2800

Research Site, Tatabánya

3000

Research Site, Leuven

4000

Research Site, Liège

4101

Research Site, South Brisbane

4400

Research Site, Nyíregyháza

4575

Research Site, Birtinya

5000

Research Site, Córdoba

Research Site, Adelaide

Research Site, Namur

Research Site, Odense

Research Site, Szolnok

6000

Research Site, Kecskemét

6020

Research Site, Innsbruck

6060

Research Site, Charleroi

6150

Research Site, Murdoch

6760

Research Site, Mexico City

7100

Research Site, Vejle

7600

Research Site, Mar del Plata

8036

Research Site, Graz

8800

Research Site, Roeselare

9000

Research Site, Ghent

Research Site, Aalborg

9024

Research Site, Győr

9100

Research Site, Sint-Niklaas

10048

Research Site, Taipei

10060

Research Site, Candiolo

10117

Research Site, Berlin

10408

Research Site, Goyang-si

10449

Research Site, Taipei

11217

Research Site, Taipei

11426

Research Site, Riyadh

11525

Research Site, Riyadh

11590

Research Site, Westbury

12713

Research Site, Riyadh

13273

Research Site, Marseille

13620

Research Site, Seongnam-si

14004

Research Site, Córdoba

14076

Research Site, Caen

15006

Research Site, A Coruña

15212

Research Site, Pittsburgh

16132

Research Site, Genova

20014

Research Site, San Sebastián

20016

Research Site, Washington D.C.

20132

Research Site, Milan

20141

Research Site, Milan

20817

Research Site, Bethesda

21079

Research Site, Dijon

21423

Research Site, Jeddah

22190

Research Site, Plerin SUR MER

22332

Research Site, Incheon

23214

Research Site, Jeddah

23502

Research Site, Norfolk

24127

Research Site, Bergamo

25000

Research Site, Besançon

28005

Research Site, Madrid

28007

Research Site, Madrid

28046

Research Site, Madrid

29609

Research Site, Brest

30120

Research Site, El Palmar

30625

Research Site, Hanover

31444

Research Site, Dammam

32224

Research Site, Jacksonville

33000

Research Site, Bordeaux

33081

Research Site, Aviano

33100

Research Site, Udine

34298

Research Site, Montpellier

35000

Research Site, Rennes

35128

Research Site, Padua

35185

Research Site, Vaxjo

37000

Research Site, Tours

37232

Research Site, Nashville

40202

Research Site, Louisville

40447

Research Site, Taichung

41013

Research Site, Seville

41404

Research Site, Daegu

42551

Research Site, Velbert

43210

Research Site, Columbus

44124

Research Site, Cona

44260

Research Site, Guadalajra

44280

Research Site, Guadalajara Jalisco

44281

Research Site, Kfar Saba

44805

Research Site, Saint-Herblain

46026

Research Site, Valencia

48149

Research Site, Münster

48202

Research Site, Detroit

49100

Research Site, Petah Tikva

52621

Research Site, Ramat Gan

55905

Research Site, Rochester

57124

Research Site, Livorno

59100

Research Site, Prato

63110

Research Site, St Louis

64239

Research Site, Tel Aviv

64460

Research Site, Monterrey

66160

Research Site, Kansas City

66278

Research Site, Nuevo León

69495

Research Site, Pierre-Bénite

70403

Research Site, Tainan City

72000

Research Site, Le Mans

72762

Research Site, Springdale

73039

Research Site, Tricase, Lecce

75005

Research Site, Paris

75246

Research Site, Dallas

77030

Research Site, Houston

77090

Research Site, Houston

78731

Research Site, Austin

79110

Research Site, Freiburg im Breisgau

80045

Research Site, Aurora

80131

Research Site, Napoli

80228

Research Site, Lakewood

81675

Research Site, München

84918

Research Site, Avignon

85259

Research Site, Scottsdale

90017

Research Site, Los Angeles

91010

Research Site, Duarte

91120

Research Site, Jerusalem

92210

Research Site, Saint-Cloud

94805

Research Site, Villejuif

98104

Research Site, Seattle

98158

Research Site, Messina

100006

Research Site, Beijing

100044

Research Site, Beijing

110005

Research Site, New Delhi

110015

Research Site, Shenyang

110017

Research Site, New Delhi

110075

Research Site, New Delhi

111123

Research Site, Moscow

115478

Research Site, Moscow

116001

Research Site, Dalian

117997

Research Site, Moscow

119074

Research Site, Singapore

121205

Research Site, Moscow

130021

Research Site, Changchun

150054

Research Site, Yaroslavl

150081

Research Site, Harbin

169610

Research Site, Bukit Merah

190103

Research Site, Saint Petersburg

195271

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

200032

Research Site, Shanghai

210009

Research Site, Nanjing

210029

Research Site, Nanjing

230001

Research Site, Hefei

250001

Research Site, Jinan

258499

Research Site, Singapore

276000

Research Site, Linyi

300060

Research Site, Tianjin

302004

Research Site, Marg Jaipur

308433

Research Site, Singapore

310003

Research Site, Hangzhou

310020

Research Site, Hangzhou

310022

Research Site, Hangzhou

329563

Research Site, Singapore

330006

Research Site, Nanchang

330009

Research Site, Nanchang

350011

Research Site, Fuzhou

350040

Research Site, Krasnodar

395002

Research Site, Surat

410008

Research Site, Changsha

410013

Research Site, Changsha

430079

Research Site, Wuhan

450008

Research Site, Zhengzhou

510060

Research Site, Guangzhou

510080

Research Site, Guangzhou

510120

Research Site, Guangzhou

528000

Research Site, Foshan

530021

Research Site, Nanning

560099

Research Site, Bengaluru

673601

Research Site, Calicut

695011

Research Site, Thiruvananthapuram

700160

Research Site, Kolkata

710004

Research Site, Xi'an

710061

Research Site, Xi'an

830000

Research Site, Ürümqi

1323001

Research Site, São Paulo

3109601

Research Site, Haifa

9103102

Research Site, Jerusalem

02114

Research Site, Boston

07901

Research Site, Summit

53792-5666

Research Site, Madison

C1125ABD

Research Site, Buenos Aires

C1012AAR

Research Site, CABA

C1019ABS

Research Site, CABA

S2000DEJ

Research Site, Rosario

S2002KDS

Research Site, Rosario

14784-400

Research Site, Barretos

30110-022

Research Site, Belo Horizonte

59075-740

Research Site, Natal

90610-000

Research Site, Porto Alegre

91350-200

Research Site, Porto Alegre

20560-120

Research Site, Rio de Janeiro

04038-034

Research Site, São Paulo

18030-510

Research Site, Sorocaba

T2N 5G2

Research Site, Calgary

T6G 1Z2

Research Site, Edmonton

V5Z 4E6

Research Site, Vancouver

M5G 2M9

Research Site, Toronto

N6A 5W9

Research Site, London

M4N 3M5

Research Site, Toronto

M5G 1X5

Research Site, Toronto

H3T 1E2

Research Site, Montreal

H4A 3J1

Research Site, Montreal

J1H 5N4

Research Site, Sherbrooke

071000

Research Site, Baoding

06100

Research Site, Nice

01307

Research Site, Dresden

D-80336

Research Site, München

110 085

Research Site, New Delhi

Unknown

Research Site, Parma

Research Site, Guildford

673-8558

Research Site, Akashi-shi

113-8431

Research Site, Bunkyō City

260-8717

Research Site, Chiba

104-0045

Research Site, Chūōku

811-1395

Research Site, Fukuoka

501-1194

Research Site, Gifu

350-1298

Research Site, Hidaka-shi

730-8518

Research Site, Hiroshima

259-1193

Research Site, Isehara

892-0833

Research Site, Kagoshima

277-8577

Research Site, Kashiwa

216-8511

Research Site, Kawasaki-shi

362-0806

Research Site, Kitaadachi-gun

135-8550

Research Site, Kōtoku

791-0280

Research Site, Matsuyama

460-0001

Research Site, Nagoya

901-0154

Research Site, Naha

951-8566

Research Site, Niigata

663-8501

Research Site, Nishinomiya-shi

700-8558

Research Site, Okayama

541-8567

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

252-0375

Research Site, Sagamihara-shi

060-8648

Research Site, Sapporo

142-8666

Research Site, Shinagawa-ku

160-0023

Research Site, Shinjuku-ku

420-8527

Research Site, Shizuoka

514-8507

Research Site, Tsu

241-8515

Research Site, Yokohama

06700

Research Site, Alc. Cuauhtémoc

'14080

Research Site, Mexico City

0 3100

Research Site, Mexico City

04700

Research Site, México

1066 CX

Research Site, Amsterdam

4818 CK

Research Site, Breda

7555 DL

Research Site, Hengelo

8934 AD

Research Site, Leeuwarden

3015 GD

Research Site, Rotterdam

6162 BG

Research Site, Sittard-Geleen

85-796

Research Site, Bydgoszcz

75-581

Research Site, Koszalin

31-501

Research Site, Krakow

90-302

Research Site, Lodz

35-021

Research Site, Rzeszów

02-781

Research Site, Warsaw

53-413

Research Site, Wroclaw

1500-650

Research Site, Lisbon

1649-035

Research Site, Lisbon

1998-018

Research Site, Lisbon

02841

Research Site, Seoul

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

08035

Research Site, Barcelona

08036

Research Site, Barcelona

08907

Research Site, Barcelona

413 45

Research Site, Gothenburg

701 85

Research Site, Örebro

118 83

Research Site, Stockholm

751 85

Research Site, Uppsala

CB2 0QQ

Research Site, Cambridge

CF14 2TL

Research Site, Cardiff

EH4 2XR

Research Site, Edinburgh

LS9 7TF

Research Site, Leeds

SE1 9RT

Research Site, London

M20 4BX

Research Site, Manchester

HA6 2RN

Research Site, Northwood

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY