Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,012

Participants

Timeline

Start Date

July 13, 2020

Primary Completion Date

October 7, 2024

Study Completion Date

March 29, 2027

Conditions
Hormone-Sensitive Prostate Cancer
Interventions
DRUG

Capivasertib

400 mg (2 tablets) BD given on an intermittent weekly dosing schedule. Patients will be dosed on Days 1 to 4 in each week of a 28-day treatment cycle. Number of Cycles: until disease progression or unacceptable toxicity develops.

OTHER

Placebo

matched to capivasertib appearance (2 tablets) BD given on an intermittent weekly dosing schedule. Patients will be dosed on Days 1 to 4 in each week of a 28-day treatment cycle. Number of Cycles: until disease progression or unacceptable toxicity develops.

DRUG

Abiraterone Acetate

Administered orally as tablets at a dosage of 1000 mg daily. Administered continuously until criteria for discontinuation are met.

Trial Locations (323)

27

Research Site, San Isidro

112

Research Site, Taipei

333

Research Site, Taoyuan

404

Research Site, Taichung

710

Research Site, Tainan City

807

Research Site, Kaohsiung City

1070

Research Site, Anderlecht

1101

Research Site, Quezon City

1112

Research Site, Quezon City

1407

Research Site, Sofia

1425

Research Site, CABA

1426

Research Site, Buenos Aires

1500

Research Site, San Juan City

1527

Research Site, Sofia

1756

Research Site, Sofia

1797

Research Site, Sofia

1900

Research Site, La Plata

2010

Research Site, Darlinghurst

2013

Research Site, Johannesburg

2193

Research Site, Johannesburg

2600

Research Site, Baguio City

2747

Research Site, Kingswood

2800

Research Site, Orange

4000

Research Site, Liège

4004

Research Site, Plovdiv

4020

Research Site, Linz

4101

Research Site, South Brisbane

4109

Research Site, Plovdiv

4575

Research Site, Birtinya

4600

Research Site, San Salvador de Jujuy

5000

Research Site, Iloilo City

5020

Research Site, Salzburg

5500

Research Site, Mendoza

5804

Research Site, Pleven

6000

Research Site, Cebu City

6045

Research Site, Port Elizabeth

7505

Research Site, Parow

7570

Research Site, Cape Town

8000

Research Site, Davao City

8036

Research Site, Graz

8500

Research Site, Kortrijk

9000

Research Site, Ghent

Research Site, Varna

10117

Research Site, Berlin

10210

Research Site, Bangkok

10400

Research Site, Bangkok

10408

Research Site, Goyang-si

10461

Research Site, The Bronx

10700

Research Site, Bangkok

11029

Research Site, New Delhi

11490

Research Site, Taipei

13210

Research Site, Syracuse

13273

Research Site, Marseille

13620

Research Site, Seongnam-si

15232

Research Site, Pittsburgh

17601

Research Site, Lancaster

19111

Research Site, Philadelphia

20246

Research Site, Hamburg

21201

Research Site, Baltimore

22000

Research Site, Muang

23502

Research Site, Norfolk

24014

Research Site, Roanoke

25030

Research Site, Besançon

26040

Research Site, Eskişehir

27710

Research Site, Durham

28007

Research Site, Madrid

28034

Research Site, Madrid

28040

Research Site, Madrid

28041

Research Site, Madrid

28805

Research Site, Asheville

29107

Research Site, Quimper

29401

Research Site, Charleston

29572

Research Site, Myrtle Beach

33011

Research Site, Oviedo

33076

Research Site, Bordeaux

33401

Research Site, West Palm Beach

34098

Research Site, Istanbul

34298

Research Site, Montpellier

35016

Research Site, Las Palmas de Gran Canaria

35033

Research Site, Rennes

35100

Research Site, Izmir

35575

Research Site, Izmir

37404

Research Site, Chattanooga

38039

Research Site, Kayseri

39008

Research Site, Santander

40822

Research Site, Mettmann

41009

Research Site, Seville

41404

Research Site, Daegu

43210

Research Site, Columbus

43503

Research Site, Taichung

44625

Research Site, Herne

44680

Research Site, Guadalajara

46483

Research Site, Wesel

47169

Research Site, Duisburg

48084

Research Site, Troy

48149

Research Site, Münster

48201

Research Site, Detroit

49401

Research Site, Nitra

49503

Research Site, Grand Rapids

50200

Research Site, Chiang Mai

52000

Research Site, Lampang

52621

Research Site, Ramat Gan

53792

Research Site, Madison

60134

Research Site, Geneva

60532

Research Site, Lisle

60637

Research Site, Chicago

64460

Research Site, Monterrey

66278

Research Site, Nuevo León

67033

Research Site, Strasbourg

69495

Research Site, Pierre-Bénite

70300

Research Site, Ẕerifin

72622

Research Site, Nürtingen

75674

Research Site, Paris

77090

Research Site, Houston

80040

Research Site, Culiacán

80211

Research Site, Denver

80215

Research Site, Lakewood

80230

Research Site, Culiacán

81102

Research Site, Bratislava

81362

Research Site, Kaohsiung City

85723

Research Site, Tucson

85741

Research Site, Tucson

90110

Research Site, Hat Yai

90419

Research Site, Nuremberg

91120

Research Site, Jerusalem

92037

Research Site, La Jolla

92123

Research Site, San Diego

92151

Research Site, Suresnes

92701

Research Site, Šaľa

92868

Research Site, Orange

94805

Research Site, Villejuif

95847

Research Site, Kfar Saba

98104

Research Site, Seattle

100000

Research Site, Hanoi

Research Site, Hà Nội

100034

Research Site, Beijing

100036

Research Site, Beijing

100050

Research Site, Beijing

105077

Research Site, Moscow

110004

Research Site, Shengyang

110005

Research Site, New Delhi

110085

Research Site, Delhi

117997

Research Site, Moscow

121001

Research Site, Faridabad

121205

Research Site, Moscow

130021

Research Site, Changchun

150054

Research Site, Yaroslavl

160055

Research Site, Mohali

190103

Research Site, Saint Petersburg

191014

Research Site, Saint Petersburg

200032

Research Site, Shanghai

200080

Research Site, Shanghai

200127

Research Site, Shanghai

208005

Research Site, Kanpur

210009

Research Site, Nanjing

221005

Research Site, Varanasi

226361

Research Site, Nantong

250001

Research Site, Meerut

264000

Research Site, Yantai

300211

Research Site, Tianjin

310003

Research Site, Hangzhou

310014

Research Site, Hangzhou

310052

Research Site, Hangzhou

315000

Research Site, Ningbo

330006

Research Site, Nanchang

350001

Research Site, Fuzhou

350005

Research Site, Fuzhou

380060

Research Site, Ahmedabad

400030

Research Site, Chongqing

400038

Research Site, Chongqing

410003

Research Site, Changsha

410008

Research Site, Changsha

430030

Research Site, Wuhan

440001

Research Site, Nagpur

450000

Research Site, Zhengzhou

450008

Research Site, Zhengzhou

510060

Research Site, Guangzhou

510180

Research Site, Guangzhou

510515

Research Site, Guangzhou

550002

Research Site, Guiyang

560022

Research Site, Bangalore

560027

Research Site, Bangalore

576104

Research Site, Manipal

610000

Research Site, Chengdu

610072

Research Site, Chengdu

625107

Research Site, Madurai

630007

Research Site, Novosibirsk

630082

Research Site, Novisibirsk

650118

Research Site, Kunming

700000

Research Site, Ho Chi Minh City

700160

Research Site, Kolkata

710061

Research Site, Xi'an

2100008

Research Site, Nanjing

2540488

Research Site, Viña del Mar

3109601

Research Site, Haifa

4781156

Research Site, Temuco

4941492

Research Site, Petah Tikva

7500653

Research Site, Santiago

7500787

Research Site, Santiago

8420383

Research Site, Santiago

06360

Research Site, Norwich

33901-8101

Research Site, Fort Myers

B1884BBF

Research Site, Berazategui

C1120AAT

Research Site, Buenos Aires

C1012AAR

Research Site, CABA

C1280AEB

Research Site, Ciudad de Buenos Aires

S2000DEJ

Research Site, Rosario

66073-005

Research Site, Belém

30110-022

Research Site, Belo Horizonte

88020-210

Research Site, Florianópolis

60135-237

Research Site, Fortaleza

17210-120

Research Site, Jaú

89201-260

Research Site, Joinville

90035-000

Research Site, Porto Alegre

90050-170

Research Site, Porto Alegre

90160-093

Research Site, Porto Alegre

14051-140

Research Site, Ribeirão Preto

20230-130

Research Site, Rio de Janeiro

97015-450

Research Site, Santa Maria

15090-000

Research Site, São José do Rio Preto

01327-001

Research Site, São Paulo

79601-001

Research Site, Três Lagoas

T2N 5G2

Research Site, Calgary

T6G 1Z2

Research Site, Edmonton

V1Y 5L3

Research Site, Kelowna

V5Z 1H7

Research Site, Vancouver

L6R 3J7

Research Site, Brampton

L1G 2B9

Research Site, Oshawa

M4N 3M5

Research Site, Toronto

M5G 2M9

Research Site, Toronto

H3T 1E2

Research Site, Montreal

CN-100730

Research Site, Beijing

CN-325000

Research Site, Wenzhou

656 91

Research Site, Brno

268 31

Research Site, Hořovice

500 05

Research Site, Hradec Králové

100 34

Research Site, Prague

120 00

Research Site, Prague

180 81

Research Site, Prague

06100

Research Site, Nice

00000

Research Site, Hong Kong

Unknown

Research Site, Hong Kong

Research Site, Lai Chi Kok

Research Site, Ankara

695 011

Research Site, Thiruvananthapuram

113-8431

Research Site, Bunkyō City

260-8677

Research Site, Chiba

260-8717

Research Site, Chūōku

812-8582

Research Site, Fukuoka

431-3192

Research Site, Hamamatsu

573-1191

Research Site, Hirakata-shi

036-8563

Research Site, Hirosaki-shi

259-1193

Research Site, Isehara-shi

920-8641

Research Site, Kanazawa

634-8522

Research Site, Kashihara-shi

350-8550

Research Site, Kawagoe-shi

292-8535

Research Site, Kisarazu-shi

761-0793

Research Site, Kita-gun

650-0047

Research Site, Kobe

860-0008

Research Site, Kumamoto

606-8507

Research Site, Kyoto

889-1692

Research Site, Miyazaki

028-3695

Research Site, Morioka

381-8551

Research Site, Nagano

852-8501

Research Site, Nagasaki

466-8560

Research Site, Nagoya

466-8650

Research Site, Nagoya

981-1293

Research Site, Natori-shi

541-8567

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

373-8550

Research Site, Ota Shi

252-0375

Research Site, Sagamihara-shi

060-8648

Research Site, Sapporo

160-8582

Research Site, Shinjuku-ku

791-0295

Research Site, Toon-shi

514-8507

Research Site, Tsu

755-8505

Research Site, Ube-shi

232-0024

Research Site, Yokohama

238-8558

Research Site, Yokosuka-shi

879-5593

Research Site, Yufu-shi

0 3100

Research Site, Mexico City

1066 CX

Research Site, Amsterdam

1213 XZ

Research Site, Hilversum

4708 AE

Research Site, Roosendaal

2545 CH

Research Site, The Hague

5042AD

Research Site, Tilburg

3543 AZ

Research Site, Utrecht

CALLAO 02

Research Site, Callao

0051

Research Site, Lima

LIMA 29

Research Site, Lima

LIMA 31

Research Site, Lima

Lima 32

Research Site, Lima

LIMA 34

Research Site, Lima

85-796

Research Site, Bydgoszcz

80-952

Research Site, Gdansk

75-581

Research Site, Koszalin

90-242

Research Site, Lodz

10-228

Research Site, Olsztyn

61-731

Research Site, Poznan

35-055

Research Site, Rzeszów

87-100

Research Site, Torun

02-781

Research Site, Warsaw

04-073

Research Site, Warsaw

851 05

Research Site, Bratislava

036 59

Research Site, Martin

08001

Research Site, Prešov

911 01

Research Site, Trenčín

0084

Research Site, Pretoria

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

08916

Research Site, Badalona (Barcelona)

08041

Research Site, Barcelona

06010

Research Site, Ankara

07059

Research Site, Antalya

CB2 0QQ

Research Site, Cambridge

GU2 7XX

Research Site, Guildford

M20 4BX

Research Site, Manchester

PL6 8DH

Research Site, Plymouth

SM2 5PT

Research Site, Sutton

CF14 2TL

Research Site, Whitchurch

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY