69
Participants
Start Date
November 13, 2020
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
Tests of sympathetic inhibition
Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.
Tests of sympathetic activation
Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).
Testing of autonomic dysreflexia
Cold pressor test of the foot and bladder pressor response (in individuals with SCI) will be tested.
RECRUITING
Mayo Clinic, Rochester
Lead Sponsor
Mayo Clinic
OTHER