Deciphering Preserved Autonomic Function After Spinal Cord Injury

NARecruitingINTERVENTIONAL
Enrollment

69

Participants

Timeline

Start Date

November 13, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Spinal Cord InjuriesAutonomic ImbalanceAutonomic DysreflexiaOrthostatic Hypotension
Interventions
DIAGNOSTIC_TEST

Tests of sympathetic inhibition

Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.

DIAGNOSTIC_TEST

Tests of sympathetic activation

Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).

DIAGNOSTIC_TEST

Testing of autonomic dysreflexia

Cold pressor test of the foot and bladder pressor response (in individuals with SCI) will be tested.

Trial Locations (1)

55902

RECRUITING

Mayo Clinic, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT04493372 - Deciphering Preserved Autonomic Function After Spinal Cord Injury | Biotech Hunter | Biotech Hunter