Adaptive COVID-19 Treatment Trial 3 (ACTT-3)

PHASE3CompletedINTERVENTIONAL
Enrollment

969

Participants

Timeline

Start Date

August 5, 2020

Primary Completion Date

December 21, 2020

Study Completion Date

December 21, 2020

Conditions
COVID-19
Interventions
DRUG

Interferon beta-1a

Rebif (R) is a purified 166 amino acid human interferon beta glycoprotein with an amino acid sequence identical to natural fibroblast derived human interferon beta. Each 0.5 mL prefilled syringe contains 44 mcg of interferon beta-1a, 4 mg human albumin, USP; 27.3 mg mannitol, USP; 0.4 mg sodium acetate; and water for injection, USP.

OTHER

Placebo

The interferon beta-1a placebo contains either 0.5 mL 0.9% normal saline or 0.5 mL sterile water for injection.

DRUG

Remdesivir

Drug Remdesivir is a single diastereomer monophosphoramidate prodrug designed for the intracellular delivery of a modified adenine nucleoside analog GS-441524. In addition to the active ingredient, the lyophilized formulation of Remdesivir contains the following inactive ingredients: water for injection, sulfobutylether beta-cyclodextrin sodium (SBECD), and hydrochloric acid and/or sodium hydroxide.

Trial Locations (64)

14080

Instituto Nacional de Enfermedades Respiratorias (INER) - Ismael Cosío Villegas, Mexico City

17033

Penn State Health Milton S. Hershey Medical Center - Division of Infectious Diseases, Hershey

20889

Walter Reed National Military Medical Center, Bethesda

21201

University of Maryland School of Medicine - Center for Vaccine Development - Baltimore, Baltimore

23708

Naval Medical Center Portsmouth - Infectious Disease Division, Portsmouth

27704

Duke Human Vaccine Institute - Duke Vaccine and Trials Unit, Durham

28310

Womack Army Medical Center - Pulmonary and Respiratory Services, Fort Bragg

29037

University of California San Diego Health - Jacobs Medical Center, La Jolla

30033

Atlanta VA Medical Center - Infectious Diseases Clinic, Decatur

32209

University of Florida Health - Jacksonville - Department of Emergency Medicine, Jacksonville

32610

University of Florida Health - Shands Hospital - Division of Infectious Diseases and Global Medicine, Gainesville

33136

University of Miami Miller School of Medicine - Infectious Diseases, Miami

35233

University of Alabama at Birmingham School of Medicine - Infectious Disease, Birmingham

52242

University of Iowa Hospitals & Clinics - Department of Internal Medicine, Iowa City

60612

University of Illinois at Chicago Division of Infectious Diseases, Chicago

70065

Ochsner Medical Center - Kenner - Department of Infectious Diseases, Kenner

70119

Southeast Louisiana Veterans Health Care System - Section of Infectious Diseases, New Orleans

75246

Baylor Scott & White Health - Baylor University Medical Center - North Texas Infectious Disease Consultants, Dallas

77030

Methodist Hospital - Houston, Houston

77555

University of Texas Medical Branch - Division of Infectious Disease, Galveston

78234

Brooke Army Medical Center, Fort Sam Houston

80045

Eastern Colorado Health Care System, Aurora

80204

Denver Health Division of Hospital Medicine - Main Campus, Denver

84132

University of Utah - Infectious Diseases, Salt Lake City

87106

University of New Mexico Clinical and Translational Science Center, Albuquerque

90095

University of California Los Angeles Medical Center - Westwood Clinic, Los Angeles

92314

Naval Medical Center San Diego - Infectious Disease Clinic, San Diego

93701

UCSF Fresno Center for Medical Education and Research - Clinical Research Center, Fresno

96859

Tripler Army Medical Center (TAMC), Honolulu

97227

Kaiser Permanente Northwest - Center for Health Research, Portland

98034

EvergreenHealth Infectious Disease Service, Kirkland

98431

Madigan Army Medical Center - Infectious Disease Clinic, Tacoma

99204

Providence Sacred Heart Medical Center, Spokane

119228

National University Health System - Division of Infectious Diseases, Singapore

308442

National Centre for Infectious Diseases (NCID), Singapore

529889

Changi General Hospital - Clinical Trials and Research Unit (CTRU), Singapore

92868-3298

University of California Irvine Medical Center - Infectious Disease, Orange

94304-1207

VA Palo Alto Health Care System - Infectious Diseases, Palo Alto

94304-1503

Stanford University - Stanford Hospital and Clinics - Pediatrics - Infectious Diseases, Palo Alto

95817-1460

University of California Davis Medical Center - Internal Medicine - Infectious Disease, Sacramento

94110-2859

University of California San Francisco - Zuckerberg San Francisco General Hospital - Division of HIV, ID, and Global Medicine, San Francisco

90048-1804

Cedars Sinai Medical Center, West Hollywood

30030-1705

Emory Vaccine Center - The Hope Clinic, Decatur

60611-2908

Northwestern Hospital - Infectious Disease, Chicago

21287-0005

Johns Hopkins Hospital - Medicine - Infectious Diseases, Baltimore

20892-1504

National Institutes of Health - Clinical Center, National Institute of Allergy and Infectious Diseases Laboratory Of Immunoregulation, Clinical Research Section, Bethesda

02114-2621

Massachusetts General Hospital - Infectious Diseases, Boston

01655-0002

University of Massachusetts Medical School - Infectious Diseases and Immunology, Worcester

55455-0356

University of Minnesota Medical Center, Fairview - Infectious Diseases and International Medicine, Minneapolis

63104-1015

Saint Louis University - Center for Vaccine Development, St Louis

68198-5400

University of Nebraska Medical Center - Infectious Diseases, Omaha

10016-6402

New York University School of Medicine - Langone Medical Center - Microbiology - Parasitology, New York

14642-0001

University of Rochester Medical Center - Vaccine Research Unit, Rochester

10467-2401

Montefiore Medical Center - Infectious Diseases, The Bronx

19104-4238

Hospital of the University of Pennsylvania - Infectious Diseases, Philadelphia

75390-8884

University of Texas Southwestern Medical Center - Internal Medicine - Infectious Diseases, Dallas

77030-3411

Baylor College of Medicine - Molecular Virology and Microbiology, Houston

78229-3901

University of Texas Health Science Center at San Antonio - Infectious Diseases, San Antonio

22908-0816

University of Virginia - Acute Care Surgery, Charlottesville

162-8655

National Center for Global Health and Medicine Hospital - Disease Control and Prevention Center, Tokyo

Unknown

Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán - Departamento de Infectologia, Mexico City

Ng Teng Fong General Hospital - Infectious Disease Service, Singapore

Seoul National University Bundang Hospital - Division of Infectious Diseases, Seongnam-si

03080

Seoul National University Hospital, Seoul

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT04492475 - Adaptive COVID-19 Treatment Trial 3 (ACTT-3) | Biotech Hunter | Biotech Hunter