50
Participants
Start Date
September 29, 2020
Primary Completion Date
May 31, 2023
Study Completion Date
June 30, 2023
Sodium Lactate
"Sodium lactate is administered at 2.5mL/kg during the first surgical incision. Neurosurgeon will evaluate the brain relaxation using a validated scale once the dura is open. A stage 1(perfectly relaxed) or 2((acceptably relaxed) is considered satisfactory.~Sodium Lactate and Mannitol 20% are used at an equimolar dose"
Mannitol 20% Infusion
Mannitol 20% is administered intravenously at a dose of 5mL/kg, so 1g/kg, during the first surgical incision. Neurosurgeon will evaluate the brain relaxation using a validated scale once the dura is open. A stage 1(perfectly relaxed) or 2((acceptably relaxed) is considered satisfactory.
CHU de Besançon, Besançon
Centre Hospitalier Universitaire de Besancon
OTHER