Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

PHASE2TerminatedINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

January 7, 2021

Primary Completion Date

February 15, 2023

Study Completion Date

May 23, 2023

Conditions
Advanced Solid TumorBRAF Gene MutationBRAF Gene AlterationMEK MutationMEK AlterationMAP2K1 Gene MutationMAP2K1 Gene AlterationMAP2K2 Gene MutationMAP2K2 Gene Alteration
Interventions
DRUG

Ulixertinib

Oral, 600 mg, twice daily, for 28-days in each treatment cycle

DRUG

Physician's Choice

Physician's choice will be restricted to two approved (not off-label) treatments for each tumor histology (agents targeting BRAF or MEK kinases and experimental agents are not permitted as physician choice)).

Trial Locations (22)

10032

Columbia University Irving Medical Center, New York

10461

Montefiore Medical Center, The Bronx

15213

UPMC Hillman Cancer Center, Pittsburgh

19713

Christiana Care Health Services / Helen F. Graham Cancer Center, Newark

20016

Johns Hopkins Sibley Memorial Hospital, Washington D.C.

22031

Virginia Cancer Specialists, PC, Fairfax

27710

Duke University Medical Center / Duke Cancer Institute, Durham

32224

Mayo Clinic, Jacksonville

32610

University of Florida, Gainesville

37203

Tennessee Oncology, PLLC - Sarah Cannon (SCRI), Nashville

45429

Kettering Cancer Center, Kettering

53792

University of Wisconsin Clinical Science Center, Madison

54449

Marshfield Medical Center, Marshfield

55416

Metro-Minnesota Community Oncology Research Consortium (MMCORC), Saint Louis Park

55905

Mayo Clinic, Rochester

57105

Avera Cancer Institute, Sioux Falls

63110

Washington University School of Medicine - Siteman Cancer Center, St Louis

77030

MD Anderson Cancer Center, Houston

85054

Mayo Clinic, Phoenix

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

98109

University of Washington/Seattle Cancer Care Alliance, Seattle

02114

Massachusetts General Hospital, Boston

Sponsors
All Listed Sponsors
lead

BioMed Valley Discoveries, Inc

INDUSTRY

NCT04488003 - Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations | Biotech Hunter | Biotech Hunter