Small Molecule, Biologics
Total Trials
19
As Lead Sponsor
10
As Collaborator
9
Total Enrollment
646
NCT01337466
Biodistribution and Dosimetry Evaluation of [124I]FIAU
Phase: Phase 1
Role: Lead Sponsor
Start: Dec 31, 2010
Completion: Mar 31, 2013
NCT01118819
Safety Study of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies
Start: Apr 30, 2011
Completion: Jun 30, 2013
NCT01705496
[124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip Joint
Phase: Phase 2
Start: Aug 31, 2012
Completion: Nov 30, 2013
NCT01781429
Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced Malignancies
Phase: Phase 1/2
Start: Mar 31, 2013
Completion: Sep 30, 2018
NCT01764919
[124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection
Start: Apr 30, 2013
Completion: Feb 28, 2014
NCT01924689
Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies
Start: Oct 31, 2013
Completion: Oct 31, 2017
NCT02296242
Phase 1/2 Study of the ERK1/2 Inhibitor BVD-523 in Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndromes
Start: Nov 30, 2014
Completion: Jun 15, 2017
NCT02608229
BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer
Role: Collaborator
Start: Jun 6, 2016
Completion: May 21, 2020
NCT02994732
Absorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled BVD-523 in Volunteers
Start: Jan 31, 2017
Completion: May 15, 2017
NCT03454035
Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors
Start: Jan 30, 2018
Completion: Nov 24, 2026
NCT03417739
A Phase II Study of BVD-523 in Metastatic Uveal Melanoma
Start: Mar 26, 2018
Completion: Aug 31, 2025
NCT03435952
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT
Start: Jul 10, 2018
Completion: Oct 1, 2026
NCT04145297
Ulixertinib (BVD-523) and Hydroxychloroquine in Patients W Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas
Start: Mar 17, 2020
Completion: Aug 18, 2022
NCT04488003
Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations
Start: Jan 7, 2021
Completion: May 23, 2023
NCT05221320
Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies
Start: May 26, 2022
Completion: Jul 14, 2024
NCT05804227
Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Gliomas
Phase: Early Phase 1
Start: Apr 20, 2023
Completion: Sep 22, 2027
NCT05985954
Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy
Start: Jan 18, 2024
Completion: Mar 28, 2028
NCT06411821
Ulixertinib in People With Histiocytic Neoplasms
Start: May 7, 2024
Completion: May 31, 2027
NCT06773195
A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis
Start: Jan 7, 2025
Completion: Jan 31, 2028
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