1,074
Participants
Start Date
September 30, 2020
Primary Completion Date
August 11, 2023
Study Completion Date
June 29, 2027
Amivantamab
Participants will receive amivantamab intravenously.
Osimertinib
Participants will receive osimertinib capsules orally.
Lazertinib
Participants will receive lazertinib tablets orally.
Placebo
Participants will receive matching placebo orally.
Chung Shan Medical University Hospital, Taichung
National Cheng Kung University Hospital, Tainan City
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City
E-DA Hospital, Kaohsiung City
Chang Gung Medical Foundation, Kaohsiung City
Cliniques Universitaires Saint Luc, Brussels
Clinique Saint Pierre, Ottignies
Tudogyogyintezet Torokbalint, Törökbálint
Westmead Hospital, Westmead
Southern Medical Day Care Centre, Wollongong
UZ Leuven, Leuven
Austin Hospital, Heidelberg
Cabrini Medical Centre, Malvern
Mátrai Gyógyintézet-Bronchológia, Gyöngyös
Princess Alexandra Hospital, Woolloongabba
Flinders Medical Centre, Bedford Park
Sir Charles Gairdner Hospital, Nedlands
Grand Hopital De Charleroi Site Les Viviers, Charleroi
St John of God Hospital Murdoch, Murdoch
Gazi University Hospital, Ankara
Ankara Bilkent City Hospital, Ankara
Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz, Székesfehérvár
Korea University Guro Hospital, Seoul
Veszprém Megyei Tudőgyógyintézet, Farkasgyepü
Algemeen Ziekenhuis Delta, Roeselare
Markusovszky Egyetemi Oktatokorhaz, Szombathely
National Taiwan University Hospital, Taipei
Aou San Luigi Gonzaga, Orbassano
Phramongkutklao Hospital and Medical College, Bangkok
Siriraj Hospital, Bangkok
Hospital Pulau Pinang, George Town
Seoul National University Bundang Hospital, Seongnam-si
Hopital Nord, Marseille
Médica Sur, Mexico City
Instituto Nacional de Cancerologia, México
Helios Klinikum Emil von Behring GmbH, Berlin
Hosp Univ A Coruna, A Coruña
University of Pittsburgh Medical Center, Pittsburgh
Institut Català D'Oncologia Girona, Girona
San Gerardo Hospital, Monza
Istituto Clinico Humanitas, Rozzano
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan
IRCCS Ospedale San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Istituto Europeo di Oncologia, Milan
Maryland Oncology Hematology, PA, Columbia
Trakya University Medical Faculty, Edirne
Virginia Cancer Specialists, Fairfax
Taipei Medical University Shuang Ho Hospital, New Taipei City
Hospital Tengku Ampuan Afzan, Kuantan
Pius-Hospital Oldenburg, Oldenburg
Hosp. Gral. Univ. Gregorio Maranon, Madrid
Hosp. Univ. 12 de Octubre, Madrid
Hosp. Univ. La Paz, Madrid
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda
Chungbuk National University Hospital, Cheongju-si
Hosp Regional Univ de Malaga, Málaga
University Cancer And Blood Center LLC, Athens
Clinica Univ. de Navarra, Pamplona
Cancer Specialists of North Florida, Jacksonville
Institut Bergonie, Bordeaux
CHU Bordeaux, Pessac
Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd, Istanbul
Medipol Mega University Hospital, Istanbul
T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi, Istanbul
Medical Point, Izmir
CHU Bretonneau, Tours
CIMOVA, Morals Vargas Centro de Investigación SC, León
Sarah Cannon Research Institute, Nashville
CHU de Grenoble Hopital Albert Michallon, La Tronche
China Medical University Hospital, Taichung
Hosp. Virgen Del Rocio, Seville
Necmettin Erbakan University Meram Medical Faculty, Konya
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara
Meir Medical Center, Kfar Saba
CHU Nantes, Sain-Herblain
Universitaetsklinikum Essen, Essen
Hosp. Gral. Univ. Valencia, Valencia
Beacon Hospital Sdn Bhd, Petaling Jaya
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola
Inje University Haeundae Paik Hospital, Busan
Ospedale S. Maria Delle Croci, Ravenna
Henry Ford Hospital, Detroit
Rabin Medical Center, Petah Tikva
Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4, Dnipro
Hosp. Clinico Univ. Lozano Blesa, Zaragoza
Chiang Mai University, Chiang Mai
Hospital Kuala Lumpur, Kuala Lumpur
Kliniken der Stadt Koeln gGmbH, Cologne
Oncologia Integral Satelite, Naucalpan
Minnesota Oncology Hematology P A, Edina
Mayo Clinic, Rochester
Institute Coeur Poumon, Lille
University Malaya Medical Centre, Kuala Lumpur
Municipal non-profit enterprise 'Regional Center of Oncology', Kharkiv
Washington University School Of Medicine, St Louis
i Can Oncology Center, Monterrey
Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg
Hospices Civils de Lyon HCL, Bron
East Jefferson General Hospital, Metairie
Robert-Bosch-Krankenhaus - Klinik Schillerhoehe, Stuttgart
Onkologische Schwerpunktpraxis, Heilbronn
Institut Curie, Paris
Hopital Tenon, Paris
Oncology Consultants Texas, Houston
Texas Oncology P A, Austin
Ospedale Monaldi, Napoli
Rocky Mountain Cancer Centers, Lone Tree
Hospital Sultan Ismail, Johor Bahru
Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting, Gauting
Ospedale San Giuseppe Moscati di Avellino, Avellino
Yuma Regional Medical Center, Yuma
Arizona Oncology Associates, PC - HAL, Goodyear
CHU de Limoges, Limoges
Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal, Uzhhorod
Songklanagarind Hospital, Prince of Songkla University, Songkhla
City of Hope Long Beach Elm, Long Beach
University of California Irvine, Orange
HIA Begin, Saint-Mandé
Institut Gustave Roussy, Villejuif
Azienda Ospedaliero Univ. Policlinico Gaspare Rodolico, Catania
Willamette Valley Cancer Institute and Research Center, Eugene
Zentralklinik Bad Berka GmbH, Bad Berka
Beijing Friendship Hospital Capital Medical University, Beijing
Beijing Cancer Hospital, Beijing
Chinese PLA General Hospital, Beijing
Beijing Chest hospital, Capital medical university, Beijing
Shengjing Hospital Of China Medical University, Shenyang
MCK, Moscow
Jilin cancer hospital, Changchun
Moscow City Oncology Hospital № 62, Krasnogorsk
Harbin medical university cancer hospital, Harbin
Yaroslavl Regional Clinical Oncology Hospital, Yaroslavl
Leningrad Regional Oncology Dispensary, Kuzmolovsky
Current medical technologies, Saint Petersburg
Oncology Medical Clinics AV Medical group, Saint Petersburg
N.N. Petrov Research Institute Of Oncology, Saint Petersburg
Ruijin Hospital Shanghai Jiao Tong University, Shanghai
Shanghai Chest Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Shanghai East Hospital, Shanghai
The First People's Hospital Of Changzhou, Changzhou
Nantong Tumor Hospital, Nantong
Yantai Yuhuangding Hospital, Yantai
Tianjin Medical University General Hospital, Tianjin
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Taizhou Hospital of Zhejiang Province, Linhai
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
City Clinical Hospital #1, Nal'chik
Tambov Regional Oncology Clinical Dispansary, Tambov
Tata Memorial Hospital, Mumbai
Southwest Hospital, Chongqing
Hunan Cancer hospital, Changsha
Noble Hospital Pvt Ltd, Pune
HCG Manavta Cancer Centre, Nashik
TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology, Wuhan
Henan Cancer Hospital, Zhengzhou
Bashkir State Medical University, Ufa
Basavatarakam Indo-American Hospital, Hyderabad
The First Affiliated Hospital Sun Yat sen University, Guangzhou
Sun Yat-Sen Memorial Hospital Sun Yat-sen University, Guangzhou
Huizhou Municipal Central Hospital, Huizhou
Nizhny Novgorod Regional Oncological Dispensary, Nizhny Novgorod
Sichuan Cancer Hospital, Chengdu
West China Hospital Sichuan University, Chengdu
Tomsk Cancer Research Institute, Tomsk
Krasnoyarsk Regional Oncology Dispensary, Krasnoyarsk
Omsk Clinical Oncology Dispensary, Omsk
Irkutsk Regional Oncology Dispensary, Irkutsk
Tata Medical Center, Kolkata
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
Cancer Hospital of Xinjiang Medical University, Ürümqi
Rambam Health Corporation, Haifa
Chaim Sheba Medical Center, Ramat Gan
Tel Aviv Sourasky Medical Center, Tel Aviv
Hadassah Medical Center, Jerusalem
Astera Cancer Care, East Brunswick
Centro Oncológico Korben, Buenos Aires
Instituto Alexander Fleming, Buenos Aires
Hospital Privado Centro Medico de Cordoba, Córdoba
Centro Oncologico Riojano Integral (Cori), La Rioja
Clínica Viedma, Viedma
Fundacao Pio XII, Barretos
Cetus Oncologia, Belo Horizonte
Ynova Pesquisa Clinica, Florianópolis
Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda, Ijuí
Liga Norte Riograndense Contra O Cancer, Natal
UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas
Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre
Ministerio da Saude Instituto Nacional do Cancer, Rio de Janeiro
Oncoclinicas Rio de Janeiro S A, Rio de Janeiro
Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro
Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo, São Paulo
Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo
Núcleo de Pesquisa São Camilo, São Paulo
IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado, Sorocaba
Hospital Evangélico de Cachoeiro de Itapemirim, Vitória
William Osler Health System, Brampton
Juravinski Cancer Centre, Hamilton
The Ottawa Hospital Cancer Centre, Ottawa
McGill University Health Centre, Montreal
Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH, Halle
POIS Leipzig GbR, Leipzig
Orszagos Koranyi Tbc es Pulmonologiai Intezet, Budapest
Irccs Gemelli, Roma
Juntendo University Hospital, Bunkyō City
National Cancer Center Hospital, Chūōku
National Hospital Organization Kyushu Medical Center, Fukuoka
National Hospital Organization Himeji Medical Center, Himeji
Kansai Medical University Hospital, Hirakata
Kanazawa University Hospital, Kanazawa
National Cancer Center Hospital East, Kashiwa
Kurume University Hospital, Kurume
Matsusaka Municipal Hospital, Matsusaka
Niigata Cancer Center Hospital, Niigata
Okayama University Hospital, Okayama
Kindai University Hospital, Osaka Sayama Shi
National Hospital Organization Shibukawa Medical Center, Shibukawa
The Cancer Institute Hospital of JFCR, Tokyo
National Hospital Organization Tokyo Medical Center, Tokyo
Ehime University Hospital, Toon-shi
National Hospital Organization Osaka Toneyama Medical Center, Toyonaka-shi
Wakayama Medical University Hospital, Wakayama
National Hospital Organization Iwakuni Clinical Center, Yamaguchi
National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi
Mexico Centre for Clinical Research, S.A. de C.V., Mexico City
Health Pharma Professional Research, México
Jeroen Bosch Ziekenhuis, 's-Hertogenbosch
Rijnstate Ziekenhuis, Arnhem
Ziekenhuis St Jansdal, Harderwijk
UMC Radboud, Nijmegen
Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz
Uniwersyteckie Centrum Kliniczne, Gdansk
Szpitale Pomorskie Sp z o o, Gdynia
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn
Private Specialist Hospitals - MedPolonia, Poznan
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw
Uls Santa Maria - Hosp. Pulido Valente, Lisbon
Uls Santo Antonio - Hosp. Santo Antonio, Porto
Hosp. Cuf Porto, Porto
Instituto Portugues de Oncologia, Porto
Pan American Center for Oncology Trials LLC, Rio Piedras
Kangbuk Samsung Hospital, Seoul
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul St Mary s Hospital, Seoul
Inst. Cat. D'Oncologia-Badalona, Badalona
Hosp. de La Santa Creu I Sant Pau, Barcelona
Hosp. Univ. Quiron Dexeus, Barcelona
Hosp Univ Vall D Hebron, Barcelona
Hosp. Univ. de Burgos, Burgos
Adana City Hospital, Adana
Başkent University Medical Faculty Adana Application and Research Center, Adana
Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies', Kyiv
National Cancer Institute, Kyiv
Edinburgh Cancer Centre Western General, Edinburgh
UCL Cancer Institute, London
Chelsea And Westminster Hospital, London
The Royal Marsden NHS Trust, London
Christie NHS Foundation Trust, Manchester
Nottingham University Hospitals NHS Trust, Nottingham
The Royal Marsden NHS Trust, Sutton
Janssen Research & Development, LLC
INDUSTRY