Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

PHASE1RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

December 9, 2020

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Recurrent World Health Organization (WHO) Grade II GliomaLow-grade GliomaHigh Grade Glioma
Interventions
DRUG

Everolimus

Given PO

DRUG

Trametinib

Given PO

Trial Locations (18)

10016

RECRUITING

New York University, New York

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21287

RECRUITING

John Hopkins University, Baltimore

35233

RECRUITING

University of Alabama at Birmingham, Children's of Alabama, Birmingham

46202

RECRUITING

Riley Hospital for Children, Indianapolis

55404

RECRUITING

Children's Minnesota, Minneapolis

60611

RECRUITING

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

63110

RECRUITING

Washington University in St. Louis, St Louis

75235

RECRUITING

University Of Texas Southwestern Medical Center, Dallas

77030

RECRUITING

Texas Children's Hospital, Houston

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

92123

RECRUITING

University of California, San Diego Rady Children's Hospital, San Diego

94143

RECRUITING

University of California, San Francisco, San Francisco

97239

RECRUITING

Doernbecher Children's Hospital Oregon Health & Science University, Portland

32610-0265

RECRUITING

University of Florida, Gainesville

02215

WITHDRAWN

Dana Farber Cancer Institute, Boston

07601

RECRUITING

Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

collaborator

Pediatric Brain Tumor Foundation

UNKNOWN

collaborator

The Lilabean Foundation for Pediatric Brain Cancer Research

UNKNOWN

lead

University of California, San Francisco

OTHER