Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

PHASE3CompletedINTERVENTIONAL
Enrollment

252

Participants

Timeline

Start Date

September 29, 2020

Primary Completion Date

April 13, 2023

Study Completion Date

January 29, 2025

Conditions
Myelofibrosis (MF)
Interventions
DRUG

Navitoclax

Tablet; Oral

DRUG

Ruxolitinib

Tablet; Oral

DRUG

Placebo for Navitoclax

Tablet; Oral

Trial Locations (194)

100

National Taiwan University Hospital /ID# 218976, Taipei City

333

Linkou Chang Gung Memorial Hospital /ID# 218983, Taoyuan

833

Kaohsiung Chang Gung Memorial Hospital /ID# 218984, Kaohsiung City

1090

Medizinische Universitaet Wien /ID# 220906, Vienna

1140

Hanusch Krankenhaus /ID# 220909, Vienna

1407

Acibadem City Clinic Tokuda University Hospital EAD /ID# 231036, Sofia

1431

UMHAT Alexandrovska EAD /ID# 231056, Sofiya

UMHAT Sveti Ivan Rilski /ID# 231028, Sofia

1864

Wits Clinical Research /ID# 232072, Johannesburg

2010

The Kinghorn Cancer Centre /ID# 221503, Darlinghurst

2025

Aotearoa Clinical Trials /ID# 230770, Papatoetoe

2030

ZAS Cadix /ID# 221465, Antwerp

2170

Liverpool Hospital /ID# 221803, Liverpool

2193

Duplicate_Wits Clinical Research Site /ID# 232071, Johannesburg

2250

Gosford Hospital /ID# 221499, Gosford

2640

Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 231311, East Albury

3000

Peter MacCallum Cancer Ctr /ID# 229795, Melbourne

Universitair Ziekenhuis Leuven /ID# 218806, Leuven

3004

The Alfred Hospital /ID# 221501, Melbourne

4000

CHU de Liège /ID# 218874, Liège

4002

UMHAT Sveti Georgi /ID# 231053, Plovdiv

4010

Ordensklinikum Linz GmbH Elisabethinen /ID# 220813, Linz

4600

Klinikum Wels-Grieskirchen GmbH /ID# 220901, Wels

4814

Townsville University Hospital /ID# 229794, Douglas

5530

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 221127, Yvoir

5800

UMHAT Dr Georgi Stranski EAD /ID# 231161, Pleven

6000

Royal Perth Hospital /ID# 223203, Perth

8000

AZ Sint-Jan Brugge /ID# 218805, Bruges

8010

Duplicate_Medizinische Universitaet Graz /ID# 220910, Graz

8800

AZ-Delta /ID# 221466, Roeselare

9000

UZ Gent /ID# 221125, Ghent

9100

Vitaz /Id# 229861, Sint-Niklaas

10000

Clinical Hospital Dubrava /ID# 230795, Zagreb

Klinicka bolnica Merkur /ID# 231155, Zagreb

Klinicki bolnicki centar Zagreb /ID# 230793, Zagreb

10065

Weill Cornell Medical College /ID# 220933, New York

10676

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 230786, Athens

11000

University Clinical Center Serbia /ID# 230854, Belgrade

11042

Northwell Health - Monter Cancer Center /ID# 222996, Lake Success

11080

Clin Hosp Ctr Bezanijska Kosa /ID# 230946, Belgrade

11217

Taipei Veterans General Hosp /ID# 221146, Taipei

11527

General Hospital of Athens Laiko /ID# 230785, Athens

12462

Duplicate_University General Hospital Attikon /ID# 230784, Athens

13620

Duplicate_Seoul National University Bundang Hospital /ID# 219053, Seongnam

15232

UPMC Hillman Cancer Ctr /ID# 218134, Pittsburgh

15706

Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 222264, Santiago de Compostela

21000

Duplicate_Klinicki bolnicki centar Split /ID# 230796, Split

Duplicate_Clinical Center Vojvodina /ID# 230853, Novi Sad

21100

Duplicate_ASST Sette Laghi /ID# 219084, Varese

21565

Gachon University Gil Medical Center /ID# 222089, Incheon

22030

Trakya University Medical Facu /ID# 230754, Edirne, Istanbul

22031

Virginia Cancer Specialists - Fairfax /ID# 242682, Fairfax

22081

OncoResearch Lerchenfeld GmbH /ID# 230867, Hamburg

24127

ASST Papa Giovanni XXIII /ID# 221907, Bergamo

25123

ASST degli Spedali Civili di Brescia /ID# 241273, Brescia

28027

CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 230721, Madrid

28034

Hospital Universitario Ramon y Cajal /ID# 220877, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 229691, Madrid

29010

Hospital Universitario Virgen de la Victoria /ID# 220878, Málaga

30029

CHU NIMES - Hopital Caremeau /ID# 219114, Nîmes

31008

Clinica Universidad de Navarra - Pamplona /ID# 230720, Pamplona

33401

Florida Cancer Specialists - East /ID# 221728, West Palm Beach

33486

Lynn Cancer Institute, Boca /ID# 230687, Boca Raton

33604

Centre Hospitalier Universitaire de Bordeaux /ID# 222518, Pessac

34000

University Clinical Center Kragujevac /ID# 230855, Kragujevac

34214

Bagcilar Medipol Mega Universite Hastanesi /ID# 230757, Istanbul

35019

Hospital Universitario Dr. Negrin /ID# 220897, Las Palmas de Gran Canaria

35040

Ege University Medical Faculty /ID# 230753, Izmir

37916

Thompson Cancer Survival Ctr /ID# 231689, Knoxville

40138

IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 220867, Bologna

40447

China Medical University Hospital /ID# 218978, Taichung

41944

Duplicate_Kyungpook National University Hospital /ID# 231666, Daegu

43210

The Ohio State University /ID# 221584, Columbus

44000

CHU de Nantes, Hotel Dieu -HME /ID# 219113, Nantes

44280

Inonu University Medical Faculty /ID# 230758, Malatya

44718

Gabrail Cancer Center Research /ID# 230488, Canton

45147

Universitaetsklinikum Essen /ID# 221522, Essen

46010

Hospital Clinico Universitario de Valencia /ID# 220875, Valencia

46237

Indiana Blood & Marrow Transpl /ID# 221586, Indianapolis

47392

Duplicate_Inje University Busan Paik Hospital /ID# 231667, Busan

49241

Pusan National University Hospital /ID# 222087, Busan

49933

Chu Angers /Id# 219115, Angers

50134

Azienda Ospedaliero Universitaria Careggi /ID# 219086, Florence

52074

Universitaetsklinikum Aachen /ID# 221519, Aachen

55435

Minnesota Oncology Hematology /ID# 227357, Edina

59100

CH Roubaix - Hopital Victor Provo /ID# 219116, Roubaix

60612

Duplicate_Rush University Medical Center /ID# 221581, Chicago

61070

Communal non-profit enterprise Regional Center of Oncology /ID# 230832, Kharkiv

61761

Mid Illinois Hematology & Oncology Associates, Ltd /ID# 224204, Normal

64132

MidAmerica Division, Inc. /ID# 221743, Kansas City

67033

ICANS - Institut de Cancérologie Strasbourg Europe /ID# 229978, Strasbourg

68167

Universitatsklinikum Mannheim /ID# 221523, Mannheim

69495

HCL - Hopital Lyon Sud /ID# 222913, Pierre-Bénite

70300

Yitzhak Shamir Medical Center /ID# 222957, Ẕerifin

72762

Highlands Oncology Group, PA /ID# 221824, Springdale

73007

Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 224506, Chambéry

73657

Chi Mei Hospital - Liouying /ID# 221145, Tainan City

75010

Hôpital Saint-Louis /ID# 221288, Paris

75015

AP-HP - Hopital Necker /ID# 231318, Paris

75702

Texas Oncology - Northeast Texas /ID# 241813, Tyler

77030

University of Texas MD Anderson Cancer Center /ID# 217994, Houston

79044

SI Institute of Blood Pathology and Transfusion Medicine of NAMS of Ukraine /ID# 230833, Lviv

80120

Rocky Mountain Cancer Centers - Littleton /ID# 222562, Littleton

81241

Haemato-Onkologie /ID# 221061, Munich

81675

Klinikum rechts der Isar /ID# 221520, Munich

84106

Utah Cancer Specialists Salt Lake Clinic /ID# 221961, Salt Lake City

91120

Hadassah Medical Center-Hebrew University /ID# 219110, Jerusalem

92093

Moores Cancer Center at UC San Diego /ID# 218012, La Jolla

92835

Providence - St. Jude Medical Center /ID# 241646, Fullerton

93000

Hopital Avicenne - APHP /ID# 221286, Bobigny

95123

AOU Policlinico G. Rodolico - San Marco /ID# 219085, Catania

125284

Moscow State budget healthcare /ID# 221025, Moscow

185019

Republican hospital named after V.A. Baranov /ID# 221412, Petrozavodsk

191024

Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221029, Saint Petersburg

194291

Leningrad Regional Clinical Hospital /ID# 221028, Saint Petersburg

197341

Almazov National Medical Research Centre /ID# 221033, Saint Petersburg

300053

Tula Regional Clinical Hospital /ID# 221027, Tula

357502

Clinic UZI 4D /ID# 221024, Pyatigorsk

3109601

Rambam Health Care Campus /ID# 219120, Haifa

4428164

Meir Medical Center /ID# 221374, Kfar Saba

5265601

The Chaim Sheba Medical Center /ID# 219137, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 219134, Tel Aviv

33901-8108

Florida Cancer Specialist - South /ID# 221726, Fort Myers

33705-1449

Florida Cancer Specialists - North /ID# 221727, St. Petersburg

30322-1013

Emory University /ID# 221562, Atlanta

30912-0003

Augusta University Georgia Cancer Center /ID# 221551, Augusta

31904-8915

Columbus Regional Research Institute /ID# 227272, Columbus

66205-2528

University of Kansas Cancer Center /ID# 218144, Fairway

02114

Massachusetts General Hospital /ID# 221559, Boston

02215-5400

Beth Israel Deaconess Medical Center /ID# 224261, Boston

02215

Dana-Farber Cancer Institute /ID# 218010, Boston

48109-5000

University of Michigan /ID# 221658, Ann Arbor

07601

Hackensack Univ Med Ctr /ID# 221654, Hackensack

45236-2725

Oncology Hematology Care, Inc. /ID# 222556, Cincinnati

84112-5500

University of Utah /ID# 221009, Salt Lake City

98108-1597

VA Puget Sound Health Care System /ID# 231691, Seattle

L4M 6M2

Royal Victoria Hospital /ID# 222636, Barrie

L8V 1C3

Juravinski Cancer Centre /ID# 221752, Hamilton

L1G 2B9

Lakeridge Health - Oshawa /ID# 222080, Oshawa

L2S 0A9

Niagara Health System /ID# 230994, St. Catharines

G1J 1Z4

CHUQ- Hôpital de l'Enfant-Jesus /ID# 221754, Québec

01307

BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221347, Dresden

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 219083, Rome

453-8511

Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 239100, Nagoya

470-1192

Fujita Health University Hospital /ID# 221537, Toyoake

260-8677

Duplicate_Chiba University Hospital /ID# 239345, Chiba

277-8577

National Cancer Center Hospital East /ID# 226093, Kashiwa-shi

791-0295

Ehime University Hospital /ID# 221443, Toon-shi

812-8582

Kyushu University Hospital /ID# 221783, Fukuoka

960-1295

Fukushima Medical University Hospital /ID# 222752, Fukushima

503-8502

Ogaki Municipal Hospital /ID# 240173, Ogaki-shi

371-0821

Gunmaken Saiseikai Maebashi Hospital /ID# 242806, Maebashi

371-8511

Gunma University Hospital /ID# 221480, Maebashi

060-8648

Duplicate_Hokkaido University Hospital /ID# 242667, Sapporo

650-0017

Kobe University Hospital /ID# 246236, Kobe

317-0077

Hitachi General Hospital /ID# 240048, Hitachi-shi

920-8641

Kanazawa University Hospital /ID# 238424, Kanazawa

893-0024

Medical Corporation Seijinkai Ikeda Hospital /ID# 242172, Kanoya-shi

606-8507

Kyoto University Hospital /ID# 238423, Kyoto

514-8507

Mie University Hospital /ID# 221664, Tsu

889-1692

University of Miyazaki Hospital /ID# 221483, Miyazaki

701-0192

Duplicate_Kawasaki Medical School Hospital /ID# 221481, Kurashiki-shi

710-8602

Kurashiki Central Hospital /ID# 221692, Kurashiki-shi

573-1191

Kansai Medical University Hospital /ID# 221482, Hirakata-shi

589-8511

Kindai University Hospital /ID# 221479, Osakasayama-shi

565-0871

Osaka University Hospital /ID# 221478, Suita-shi

343-0845

Dokkyo Medical University Saitama Medical Center /ID# 222333, Koshigaya

410-2295

Juntendo University Shizuoka Hospital /ID# 221782, Izunokuni-shi

113-8431

Juntendo University Hospital /ID# 221405, Bunkyo-ku

113-8602

Nippon Medical School Hospital /ID# 221674, Bunkyo-ku

409-3821

University of Yamanashi Hospital /ID# 221701, Chuo-shi

6525 GA

Radboud Universitair Medisch Centrum /ID# 218948, Nijmegen

3318 AT

Albert Schweitzer Ziekenhuis /ID# 224015, Dordrecht

9713 GZ

Universitair Medisch Centrum Groningen /ID# 218947, Groningen

3584 CX

Universitair Medisch Centrum Utrecht /ID# 218949, Utrecht

0044

Alberts Cellular Therapy /ID# 232073, Pretoria

03080

Seoul National University Hospital /ID# 219055, Seoul

05505

Asan Medical Center /ID# 219054, Seoul

06351

Samsung Medical Center /ID# 221068, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219056, Seoul

08916

Hospital Universitario Germans Trias i Pujol /ID# 229936, Badalona

08003

Hospital Parc de Salut del Mar /ID# 220913, Barcelona

08035

Hospital Universitario Vall d'Hebron /ID# 229690, Barcelona

221 41

Duplicate_Skane University Hospital Lund /ID# 220835, Lund

413 45

Duplicate_Sahlgrenska University Hospital /ID# 218776, Gothenburg

701 85

Orebro Universitetssjukhuset /ID# 220829, Örebro

06230

Hacettepe University Medical Faculty /ID# 230759, Ankara

02091

Medical Center OK Clinic LLC, International Institute of Clinical Research /ID# 230834, Kyiv

03143

Feofaniya Clinical Hospital of State Management of Affairs /ID# 232370, Kyiv

SE1 9RT

Guys and St Thomas NHS Foundation Trust /ID# 219185, London

LN2 4AX

United Lincolnshire Hospitals NHS Trust /ID# 231471, Lincoln

OX3 9DU

Oxford University Hospitals NHS Foundation Trust /ID# 219192, Oxford

B15 2TH

University Hospitals Birmingham NHS Foundation Trust /ID# 221333, Birmingham

M20 4BX

The Christie Hospital /ID# 219191, Manchester

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