Topical Bupivacaine Effect On The Response To Awake Extubation During Emergence From General Anesthesia

NACompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

July 20, 2020

Primary Completion Date

August 1, 2023

Study Completion Date

September 1, 2023

Conditions
Thyroid Diseases
Interventions
DRUG

normal saline 0.9%

5ml of normal saline 0.9% topically 15 min will be installed topically around the ETT using ordinary syringe before the expected end of the surgery, this will be followed by manual ventilation using about the double tidal volume for 6-8 times or more to get air bubbles distributed within the upper airway to anesthetize the oropharynx and spread around ETT to the adjacent mucosal structures (laryngopharynx, larynx, and upper part of the trachea) then the cuff will be inflated to the previous pressure and the patient will be mechanically ventilated as usual.

DRUG

Bupivacaine Hydrochloride

5 ml of bupivacaine 0.5% will be installed topically around the ETT using ordinary syringe before the expected end of the surgery, this will be followed by manual ventilation using about the double tidal volume for 6-8 times or more to get air bubbles distributed within the upper airway to anesthetize the oropharynx and spread around ETT to the adjacent mucosal structures (laryngopharynx, larynx, and upper part of the trachea) then the cuff will be inflated to the previous pressure and patient will be mechanically ventilated as usual.

Trial Locations (1)

44519

Faculty of medicine, zagazig university, Zagazig

All Listed Sponsors
lead

Zagazig University

OTHER_GOV

NCT04471597 - Topical Bupivacaine Effect On The Response To Awake Extubation During Emergence From General Anesthesia | Biotech Hunter | Biotech Hunter