Study of Atezolizumab in Combination With Cabozantinib Versus Docetaxel in Patients With Metastatic Non-Small Cell Lung Cancer Previously Treated With an Anti-PD-L1/PD-1 Antibody and Platinum-Containing Chemotherapy

PHASE3CompletedINTERVENTIONAL
Enrollment

366

Participants

Timeline

Start Date

October 1, 2020

Primary Completion Date

September 28, 2022

Study Completion Date

January 17, 2025

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Cabozantinib

Cabozantinib will be administered orally, once daily at a dose of 40 mg on Days 1-21 of each cycle.

DRUG

Atezolizumab

Atezolizumab will be administered by IV infusion at a fixed dose of 1200 mg on Day 1 of each 21-day cycle.

DRUG

Docetaxel

Docetaxel will be administered by IV infusion at a starting dose of 75mg/m2 on Day 1 of each 21-day cycle.

Trial Locations (85)

1070

Institut Jules Bordet, Anderlecht

1090

Medizinische Universität Wien, Vienna

1200

Cliniques Universitaires St-Luc, Brussels

2065

Royal North Shore Hospital, St Leonards

3084

Austin Hospital Olivia Newton John Cancer Centre, Heidelberg

4020

Ordensklinikum Linz Elisabethinen, Linz

4810

Townsville Hospital, Townsville

5000

Clinique Ste-Elisabeth, Namur

5020

Lkh Salzburg - Univ. Klinikum Salzburg, Salzburg

5042

Flinders Medical Centre, Bedford Park

6009

Affinity Oncology, Nedlands

6830

Lhk Feldkirch, Rankweil

8036

Lkh-Univ. Klinikum Graz, Graz

10408

National Cancer Center, Goyang-si

13285

Hôpital Saint Joseph, Marseille

15006

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

16132

IRCCS AOU San Martino - IST, Genoa

16247

St. Vincent's Hospital, Gyeonggi-do

16499

Ajou University Medical Center, Gyeonggi-do

19008

Consultants in Medical Oncology and Hematology, Broomall

20141

Instituto Europeo di Oncologia, Milan

20817

Regional Cancer Care Associates, Bethesda

21565

Gachon University Gil Medical Center, Incheon

24060

Oncology and Hematology Associates of Southwest Virginia, Inc.,-Blacksburg, Blacksburg

25123

ASST Spedali Civili di Brescia, Brescia

28046

Hospital Universitario La Paz, Madrid

29414

Charleston Oncology, P .A, Charleston

30459

KRH Klinikum Siloah-Oststadt-Heidehaus, Hanover

33081

Irccs Centro Di Riferimento Oncologico (CRO), Aviano

33098

Brüderkrankenhaus St. Josef Paderborn, Paderborn

34298

Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque, Montpellier

35043

Universitaetsklinikum Giessen und Marburg, Marburg

35392

Universitaetsklinikum Giessen und Marburg GmbH, Giessen

38043

CHU de Grenoble, Grenoble

41014

Hospital Univ. Nuestra Señora de Valme, Seville

43100

Azienda Ospedaliero Universitaria di Parma, Parma

44033

Ulsan University Hosiptal, Ulsan

45136

KEM/Evang. Kliniken Essen Mitte gGmbH, Essen

48100

Ospedale Provinciale Santa Maria Delle Croci, Ravenna

49933

CHU Angers,Service de Pneumologie, Angers

50124

A.O.U Careggi, Florence

51109

Klinikum Koeln-Merheim, Cologne

51353

Samsung Changwon Hospital, Gyeongsangnam-do

55102

Minnesota Oncology Hematology, Saint Paul

73100

Ospedale Vito Fazzi, Lecce

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75970

Hopital Tenon, Paris

80131

AORN Ospedali dei Colli Ospedale Monaldi, Napoli

80220

Rocky Mountain Cancer Centers, Denver

84112

Huntsman Cancer Institute at The University of Utah, Salt Lake City

87042

Hopital Dupuytren, Limoges

92120

Kaiser Permanente - San Diego, San Diego

93105

Sansum Clinic, Santa Barbara

94305

Stanford University, Palo Alto

99437

Zentralklinik Bad Berka GmbH, Bad Berka

143422

MEDSI Clinical Hospital on Pyatnitsky Highway, Moscow

150054

Regional Clinical Oncology Hospital, Yaroslavl

194291

GBUZ Leningradskaya state clinical hospital, Saint Petersburg

197758

S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg

115 27

Uoa Sotiria Hospital, Athens

711 10

Univ General Hosp Heraklion, Heraklion

00151

Azienda Ospedaliera San Camillo Forlanini, Rome

00161

Policlinico Umberto I, Oncologia B, Rome

673-0021

Hyogo Cancer Center, Hyōgo

981-0914

Sendai Kousei Hospital, Miyagi

541-8567

Osaka International Cancer Institute, Osaka

104-0045

National Cancer Center Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

41-902

SP ZOZ Wojewódzki Szpital Specjalistyczny nr 4, Bytom

44-101

Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice, Gliwice

75-581

Szpital Wojewódzki im. Miko?aja Kopernika, Koszalin

4099-001

Centro Hospitalar do Porto ? Hospital de Santo António, Porto

4100-180

Hospital CUF Porto, Porto

4200-072

IPO do Porto, Porto

4434-502

CHVNG/E_Unidade 1, Vila Nova de Gaia

02841

Korea University Anam Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06591

Seoul St Mary's Hospital, Seoul

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

CB2 0QQ

Addenbrookes Hospital, Cambridge

G12 OYN

Beatson West of Scotland Cancer Centre, Glasgow

EC1A 7BE

Barts & London School of Med, London

NW1 - 2PG

University College London Hospital, London

SW10 9NH

Chelsea & Westminster Hospital, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Exelixis

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY