Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

August 31, 2020

Primary Completion Date

January 29, 2025

Study Completion Date

December 31, 2026

Conditions
Myelofibrosis (MF)
Interventions
DRUG

Navitoclax

Tablet; Oral

DRUG

Ruxolitinib

Tablet; Oral

DRUG

Best Available Therapy (BAT)

Tablet/Capsule; Oral or Solution for Subcutaneous Injection

Trial Locations (229)

100

National Taiwan University Hospital /ID# 271207, Taipei City

333

Linkou Chang Gung Memorial Hospital /ID# 218982, Taoyuan

704

National Cheng Kung University Hospital /ID# 271206, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980, Kaohsiung City

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 271389, Kaohsiung City

833

Kaohsiung Chang Gung Memorial Hospital /ID# 218985, Kaohsiung City

1090

Medizinische Universitaet Wien /ID# 220911, Vienna

1140

Hanusch Krankenhaus /ID# 220912, Vienna

1200

Cliniques Universitaires UCL Saint-Luc /ID# 224221, Brussels

1407

Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649, Sofia

1431

UMHAT Alexandrovska EAD /ID# 231652, Sofiya

UMHAT Sveti Ivan Rilski /ID# 231651, Sofia

2010

The Kinghorn Cancer Centre /ID# 221097, Darlinghurst

2025

Aotearoa Clinical Trials /ID# 232201, Papatoetoe

2030

ZAS Cadix /ID# 221468, Antwerp

2193

Duplicate_Wits Clinical Research Site /ID# 231554, Johannesburg

2298

Calvary Mater Newcastle /ID# 224324, Waratah

2640

Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 223848, East Albury

3004

The Alfred Hospital /ID# 221096, Melbourne

3010

Inselspital, Universitaetsspital Bern /ID# 223439, Bern

3100

Universitaetsklinikum St. Poelten /ID# 221709, Sankt Pölten

4000

Roskilde Sygehus /ID# 224456, Roskilde

4010

Ordensklinikum Linz GmbH Elisabethinen /ID# 220914, Linz

4031

Duplicate_Universitätsspital Basel /ID# 221261, Basel

4032

Debreceni Egyetem-Klinikai Kozpont /ID# 220947, Debrecen

4400

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 220946, Nyíregyháza

4600

Klinikum Wels-Grieskirchen GmbH /ID# 220915, Wels

5800

UMHAT Dr Georgi Stranski EAD /ID# 231650, Pleven

6000

Royal Perth Hospital /ID# 221099, Perth

Grand Hôpital De Charleroi - Notre Dame /ID# 224827, Charleroi

6720

Szegedi Tudományegyetem /ID# 220955, Szeged

7400

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 220948, Kaposvár

8000

Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 220949, Székesfehérvár

8010

Medizinische Universitaet Graz /ID# 220919, Graz

8800

AZ-Delta /ID# 221469, Roeselare

9000

UZ Gent /ID# 220841, Ghent

Aalborg University Hospital /ID# 224391, Aalborg

9010

UMHAT Sveta Marina /ID# 234119, Varna

9100

Vitaz /Id# 228150, Sint-Niklaas

10000

Clinical Hospital Dubrava /ID# 230801, Zagreb

Klinicka bolnica Merkur /ID# 230799, Zagreb

Klinicki bolnicki centar Zagreb /ID# 230798, Zagreb

10126

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 221223, Turin

10676

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179, Athens

11000

University Clinical Center Serbia /ID# 231058, Belgrade

11080

Clin Hosp Ctr Bezanijska Kosa /ID# 231059, Belgrade

11217

Taipei Veterans General Hosp /ID# 221147, Taipei

11527

General Hospital of Athens Laiko /ID# 221175, Athens

15006

Complejo Hospitalario Universitario A Coruña /ID# 224617, A Coruña

15706

Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 221616, Santiago de Compostela

17325

Pennsylvania Cancer Specialists & Research Institute /ID# 271376, Gettysburg

18014

Hospital Universitario Virgen de las Nieves /ID# 253936, Granada

18057

Universitaetsmedizin Rostock /ID# 224157, Rostock

19111

Fox Chase Cancer Center /ID# 223955, Philadelphia

20052

Fondazione IRCCS San Gerardo dei Tintori - Ospedale San Gerardo /ID# 225113, Monza

20817

American Oncology Partners of Maryland /ID# 222836, Bethesda

21000

Klinicki Bolnicki Centar (KBC) Split /ID# 230800, Split

University Clinical Center Vojvodina /ID# 231057, Novi Sad

21100

ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 234183, Varese

21565

Gachon University Gil Medical Center /ID# 220972, Incheon

22030

Trakya University Medical Facu /ID# 224572, Edirne, Istanbul

22031

Virginia Cancer Specialists - Fairfax /ID# 223016, Fairfax

22081

OncoResearch Lerchenfeld GmbH /ID# 225034, Hamburg

24127

ASST Papa Giovanni XXIII /ID# 221222, Bergamo

25443

Olympion General Clinic /ID# 261423, Pátrai

26504

University General Hospital of Patras /ID# 221178, RION Patras Achaia

28041

Hospital Universitario 12 de Octubre /ID# 233726, Madrid

28046

Hospital Universitario La Paz /ID# 224813, Madrid

29011

Hospital Regional Universitario de Malaga /ID# 221906, Málaga

30029

CHU NIMES - Hopital Caremeau /ID# 219128, Nîmes

31000

Klinicki bolnicki centar Osijek /ID# 231503, Osijek

33011

Hospital Universitario Central de Asturias /ID# 224815, Oviedo

33100

Duplicate_University Hospital Santa Maria della Misericordia /ID# 221241, Udine

33343

Mersin University Medical /ID# 224571, Mersin

33604

Centre Hospitalier Universitaire de Bordeaux /ID# 222696, Pessac

34362

The Lady Davis Carmel Medical Center /ID# 222973, Haifa

34953

Medipol Mega Üniversite Hastanesi /ID# 271374, Tuzla

35019

Hospital Universitario Dr. Negrin /ID# 220923, Las Palmas de Gran Canaria

35040

Ege University Medical Faculty /ID# 224570, Izmir

36100

Azienda ULSS 8 Berica /ID# 221079, Vicenza

37711

Hospital Universitario de Salamanca /ID# 221904, Salamanca

40138

Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 221077, Bologna

40447

China Medical University Hospital /ID# 218979, Taichung

41013

Hospital Universitario Virgen del Rocio /ID# 221932, Seville

44000

CHU de Nantes, Hotel Dieu -HME /ID# 219127, Nantes

44109

MetroHealth Medical Center /ID# 222650, Cleveland

44791

Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695, Bochum

46010

Hospital Clinico Universitario de Valencia /ID# 220920, Valencia

46237

Indiana Blood & Marrow Transpl /ID# 221587, Indianapolis

48109

University of Michigan /ID# 218463, Ann Arbor

48202

Henry Ford Hospital /ID# 221190, Detroit

49241

Pusan National University Hospital /ID# 220980, Busan

49933

Chu Angers /Id# 219129, Angers

50134

Azienda Ospedaliero Universitaria Careggi /ID# 219090, Florence

54301

HSHS St. Vincent Hospital /ID# 224468, Green Bay

55200

Ondokuz mayis University Facul /ID# 224567, Samsun

57010

General Hospital of Thessaloniki George Papanikolaou /ID# 221463, Thessaloniki

60020

Azienda Ospedaliero Universitaria delle Marche /ID# 238438, Ancona

60153

Loyola University Medical Ctr /ID# 219048, Maywood

60637

University of Chicago Medical Center /ID# 271373, Chicago

68167

Universitatsklinikum Mannheim /ID# 221529, Mannheim

69495

HCL - Hopital Lyon Sud /ID# 222695, Pierre-Bénite

70121

Duplicate_Ochsner Clinic Foundation-New Orleans /ID# 222777, New Orleans

70300

Yitzhak Shamir Medical Center /ID# 222972, Ẕerifin

72762

Highlands Oncology Group, PA /ID# 221826, Springdale

73007

Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 223771, Chambéry

73557

Stauferklinikum Schwaebisch Gmuend /ID# 223948, Mutlangen

73657

Chi Mei Hospital - Liouying /ID# 221144, Tainan City

75010

Hôpital Saint-Louis /ID# 221390, Paris

77030

Duplicate_Houston Methodist Hospital /ID# 223103, Houston

78229

University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942, San Antonio

79606

Texas Oncology - Abilene - Antilley Road /ID# 271379, Abilene

80131

Azienda Ospedaliera Universitaria Federico II /ID# 224673, Naples

81675

Klinikum rechts der Isar /ID# 221526, Munich

84106

Utah Cancer Specialists Salt Lake Clinic /ID# 221962, Salt Lake City

86150

Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025, Augsburg

89125

Grande Ospedale Metropolitano Bianchi - Melacrino - Morelli P.O. Riuniti /ID# 221220, Reggio Calabria

90127

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone /ID# 221078, Palermo

90603

Icri /Id# 221967, Whittier

91010

City of Hope /ID# 218996, Duarte

91120

Hadassah Medical Center-Hebrew University /ID# 219111, Jerusalem

92037

Moores Cancer Center /ID# 271596, La Jolla

92093

Moores Cancer Center at UC San Diego /ID# 219009, La Jolla

92835

Providence - St. Jude Medical Center /ID# 271382, Fullerton

93000

Hopital Avicenne - APHP /ID# 221287, Bobigny

95123

AOU Policlinico G. Rodolico - San Marco /ID# 219089, Catania

98201

Providence Everett /ID# 223130, Everett

125284

Moscow State budget healthcare /ID# 221116, Moscow

127644

Hospital n.a. V.V. Veresaev /ID# 225221, Moscow

191024

Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115, Saint Petersburg

197341

Almazov National Medical Research Centre /ID# 221114, Saint Petersburg

300053

Tula Regional Clinical Hospital /ID# 221302, Tula

357502

Clinic UZI 4D /ID# 221303, Pyatigorsk

1834111

HaEmek Medical Center /ID# 220839, Afula

2210001

Galilee Medical Center /ID# 225280, Nahariya

3109601

Rambam Health Care Campus /ID# 219121, Haifa

4941492

Rabin Medical Center /ID# 219139, Petah Tikva

5265601

The Chaim Sheba Medical Center /ID# 219136, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 219135, Tel Aviv

7747629

Duplicate_Assuta Ashdod Medical Center /ID# 225281, Ashdod

9765400

Hadassah Mt. Scopus /ID# 253394, Jerusalem

85224-5665

Ironwood Cancer & Res Ctr /ID# 222162, Chandler

90806-1701

Long Beach Memorial Medical Ct /ID# 224542, Long Beach

81501-6132

St. Mary's Hospital Regional Cancer Center /ID# 224229, Grand Junction

30912-0003

Augusta University Georgia Cancer Center /ID# 219051, Augusta

31904-8915

Columbus Regional Research Institute /ID# 224410, Columbus

60007-3361

Northwest Oncology & Hematology - Elk Grove Village /ID# 222818, Elk Grove Village

70112-2600

Tulane Medical Center - New Orleans /ID# 222940, New Orleans

02215

Dana-Farber Cancer Institute /ID# 218998, Boston

48073-6710

William Beaumont Hospital /ID# 222705, Royal Oak

63110-2539

Saint Louis University Cancer Center /ID# 222287, St Louis

07932-1049

Summit Medical Group-Florham Park /ID# 222620, Florham Park

07601

Hackensack Univ Med Ctr /ID# 219047, Hackensack

11548-1219

The Cancer Institute at St. Francis Hospital /ID# 231782, Greenvale

10016-6028

Manhattan Hematology Oncology MHO Associates /ID# 223193, New York

10065-6007

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081, New York

27157-0001

Atrium Health Wake Forest Baptist Medical Center /ID# 222899, Winston-Salem

19104-4238

Hospital of the University of Pennsylvania /ID# 219001, Philadelphia

98902-6388

Yakima Valley Memorial Hosp /ID# 224368, Yakima

L8V 1C3

Juravinski Cancer Centre /ID# 220887, Hamilton

K1H 8L6

Ottawa Hospital Research Institute /ID# 238858, Ottawa

M5G 2M9

University Health Network_Princess Margaret Cancer Centre /ID# 253942, Toronto

G6V 3Z1

CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433, Lévis

H4A 3J1

McGill University Health Center Research Institute /ID# 222614, Montreal

G1J 1Z4

CHUQ- Hôpital de l'Enfant-Jesus /ID# 220888, Québec

625 00

Fakultní Nemocnice Brno - Jihlavská /ID# 220959, Brno

128 08

Vseobecna fakultni nemocnice v Praze /ID# 220969, Prague

06200

Duplicate_CHU DE NICE-HOPITAL LARCHET II /ID# 256291, Nice

09116

Klinikum Chemnitz gGmbH /ID# 224575, Chemnitz

01307

BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346, Dresden

00168

Duplicate_Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita /ID# 219087, Rome

00161

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 225731, Rome

453-8511

Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150, Nagoya

470-1192

Fujita Health University Hospital /ID# 221598, Toyoake

030-8553

Aomori Prefectural Central Hospital /ID# 221778, Aomori

260-8677

Chiba University Hospital /ID# 224546, Chiba

277-8577

National Cancer Center Hospital East /ID# 226653, Kashiwa-shi

791-0295

Ehime University Hospital /ID# 221158, Toon-shi

812-8582

Kyushu University Hospital /ID# 221606, Fukuoka

960-1295

Fukushima Medical University Hospital /ID# 221877, Fukushima

501-1194

Gifu University Hospital /ID# 224371, Gifu

003-0006

Sapporo Hokuyu Hospital /ID# 221149, Sapporo

650-0047

Kobe City Medical Center General Hospital /ID# 221156, Kobe

920-8641

Kanazawa University Hospital /ID# 223028, Kanazawa

028-3695

Iwate Medical University Hospital /ID# 222044, Shiwa-gun

247-8533

Shonan Kamakura General Hospital /ID# 223030, Kamakura-shi

862-8655

Kumamoto Shinto General Hospital /ID# 255645, Kumamoto

606-8507

Kyoto University Hospital /ID# 223008, Kyoto

514-8507

Mie University Hospital /ID# 221665, Tsu

889-1692

University of Miyazaki Hospital /ID# 221821, Miyazaki

951-8520

Niigata University Medical & Dental Hospital /ID# 223034, Niigata

710-8602

Kurashiki Central Hospital /ID# 221690, Kurashiki-shi

573-1191

Kansai Medical University Hospital /ID# 257289, Hirakata-shi

565-0871

The University of Osaka Hospital /ID# 221159, Suita-shi

343-0845

Dokkyo Medical University Saitama Medical Center /ID# 222334, Koshigaya

410-2295

Juntendo University Shizuoka Hospital /ID# 221780, Izunokuni-shi

113-8431

Juntendo University Hospital /ID# 221154, Bunkyo-ku

113-8602

Nippon Medical School Hospital /ID# 221676, Bunkyo-ku

160-0023

Tokyo Medical University Hospital /ID# 221540, Shinjuku-ku

130-8575

Tokyo Metropolitan Bokutoh Hospital /ID# 254774, Sumida-ku

409-3821

University of Yamanashi Hospital /ID# 221706, Chuo-shi

108-8639

IMSUT Hospital, The Institute of Medical Science, The University of Tokyo /ID# 257944, Tokyo

64-920

ARS-MEDICAL Sp. z o.o. /ID# 238336, Piła

60-569

Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola /ID# 241031, Poznan

31-501

SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160, Krakow

20-081

Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 221124, Lublin

01-748

Lux Med Onkologia - Szpital Szamocka /Id# 221265, Warsaw

02-172

MTZ Clinical Research Powered by Pratia /ID# 221759, Warsaw

80-214

Uniwersyteckie Centrum Kliniczne /ID# 221298, Gdansk

40-519

Pratia Onkologia Katowice /ID# 224526, Katowice

93-513

Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopern /ID# 221161, Lodz

00927

Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281, San Juan

0044

Alberts Cellular Therapy /ID# 231556, Pretoria

03080

Seoul National University Hospital /ID# 219060, Seoul

06351

Samsung Medical Center /ID# 221091, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219061, Seoul

08916

Hospital Universitario Germans Trias i Pujol /ID# 233727, Badalona

08003

Hospital Parc de Salut del Mar /ID# 220922, Barcelona

08035

Hospital Universitario Vall d'Hebron /ID# 240979, Barcelona

224 84

Skane University Hospital Lund /ID# 220834, Lund

06010

Gulhane Askeri Tip Academy /ID# 224568, Ankara

06230

Hacettepe Universitesi Hastaneleri /ID# 271084, Ankara

03143

Feofaniya Clinical Hospital of State Management of Affairs /ID# 271397, Kyiv

SE1 9RT

Guys and St Thomas NHS Foundation Trust /ID# 221041, London

LN2 4AX

United Lincolnshire Hospitals NHS Trust /ID# 224613, Lincoln

NR31 6LA

James Paget University Hospitals NHS Foundation Trust /ID# 221219, Great Yarmouth

B15 2TH

University Hospitals Birmingham NHS Foundation Trust /ID# 221334, Birmingham

EH3 9HE

NHS Lothian /ID# 224378, Edinburgh

NE3 3HD

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335, Newcastle upon Tyne

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