Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

January 26, 2021

Primary Completion Date

April 14, 2026

Study Completion Date

July 10, 2026

Conditions
Endometrial Cancer
Interventions
DRUG

retifanlimab

INCMGA00012 administered intravenously on Day 1 of each 28-day cycle for up to 26 cycles.

DRUG

epacadostat

epacadostat will be administered orally BID.

DRUG

pemigatinib

pemigatinib will be administered orally QD.

DRUG

INCAGN02385

INCAGN2385 will be administered every 2 weeks

DRUG

INCAGN02390

INCAGN2390 will be administered every 2 weeks

Trial Locations (65)

10016

Laura & Isaac Perlmutter Cancer Ctr, New York

11528

Alexandra General Hospital of Athens, Athens

12462

University Hospital of West Attica - Attikon, Athens

13353

Charite - Campus Virchow-Klinikum, Berlin

15123

Hygeia Hospital, Marousi

20132

Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele, Milan

20133

Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori Milano, Milan

20141

European Institute of Oncology, Milan

22190

Cario - Centre Armoricain de Radiotherapie Imagerie Medicale Et Oncologie, Plérin

23298

Virginia Commonwealth University, Richmond

25000

Chu Besancon Hospital Jean Minjoz, Besançon

27514

University of North Carolina At Chapel Hill, Chapel Hill

30912

Georgia Cancer Center, Augusta

31100

Ospedale Santa Maria Ca Foncello, Treviso

32804

Advent Health Medical Group-Orlando 2501, Orlando

33076

Institut Bergonie, Bordeaux

33140

Mount Sinai Medical Center Comprehensive Cancer Center, Miami Beach

33176

Miami Cancer Institute, Miami

33316

Broward Health Medical Center, Fort Lauderdale

34125

Klinikum Kassel Gmbh, Kassel

35128

Iov - Istituto Oncologico Veneto Irccs, Padua

37203

Tennessee Oncology, Nashville

40138

Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi, Bologna

43026

The Ohio State University Wexner Medical Center Division of Gynecologic Oncology, Hilliard

44800

Centre de Lutte Contre Le Cancer - Institut de Cancerologie de L'Ouest - Rene Gauducheau, Saint-Herblain

47014

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori, Meldola

48201

Barbara Ann Karmanos Cancer Hospital, Detroit

54645

Euromedica General Clinic of Thessaloniki, Thessaloniki

55433

Minnesota Oncology-Maplewood, Coon Rapids

57104

Texas Oncology-Tyler, Sioux Falls

59101

Billings Clinic Cancer Center, Billings

63110

Washington University, St Louis

64132

Midwest Cancer Care, Kansas City

72100

Presidio Ospedaliero Di Summa Antonio Perrino, Brindisi

75006

Hospital Cochin Cancerologie, Paris

77380

Texas Oncology the Woodlands, Shenandoah

78240

Texas Oncology San Antonio, San Antonio

78731

Texas Oncology-Austin Center, Austin

80131

Istituto Nazionale Tumori Irccs Fondazione Pascale, Napoli

85016

Honorhealth, Phoenix

85711

Arizona Oncology Associates, Tucson

87131

New Mexico Cancer Care Alliance, Albuquerque

89074

Comprehensive Cancer Centers of Nevada, Henderson

89075

Universitarsfrauenklinik Ulm, Ulm

90048

UCLA Medical Hematology & Oncology, Los Angeles

91342

Olive View Med Ctr, Sylmar

94805

Institut Gustave Roussy, Villejuif

99508

Alaska Womens Cancer Care Akwcc, Anchorage

33612-9497

H. Lee Moffitt Cancer Center and Research Institute Hospital, Tampa

97401-8122

Willamette Valley Cancer Institute, Eugene

76104-3902

Texas Oncology-Fort Worth South Henderson, Fort Worth

09300

O.L.V Ziekenhuis, Aalst

01000

Institut Jules Bordet, Brussels

09000

Ghent University Hospital, Ghent

03000

Universitaire Ziekenhuis Leuven - Gasthuisberg, Leuven

04000

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège

05000

Chu Ucl Namur de Saint Elisabeth, Namur

06000

High Technology Hospital Medcenter, Batumi

04600

Jsc Evex Hospitals, Kutaisi

00112

Todua Clinic, Llc, Tbilisi

00186

Caucasus Medical Centre Llc, Tbilisi

INNOVA, Tbilisi

Multiprofile Clinic Consilium Medulla Llc, Tbilisi

01307

University Clinic Carl Gustav Carus Technical University Dresden, Dresden

00168

Fondazione Policlinico Universitario Agostino Gemelli Irccs, Roma

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

GOG Foundation

NETWORK

collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

lead

Incyte Corporation

INDUSTRY