FDOPA PET and Nutritional Support in Parkinson's Disease

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 30, 2020

Primary Completion Date

April 11, 2025

Study Completion Date

January 8, 2027

Conditions
Parkinson DiseaseIdiopathic Parkinson Disease
Interventions
DIETARY_SUPPLEMENT

N acetyl cysteine

Intervention: IV NAC infusion: Dose: 50mg in 200ml of Dextrose 5% in Water (D5W), frequency: over one hour 1 x per week for 90 days ± 30 days AND Oral N-acetyl Cysteine - one 500 mg tablet 2 x per day (on days IV N-acetyl cysteine is not administered)

DRUG

[F-18] Fluorodopa Positron Emission Tomography

FDOPA PET diagnostic imaging to to measure dopamine function, serum measures of NAC concentrations, magnetic resonance spectroscopy (MRS) to measure inflammatory and oxidative stress markers, and neurological measures to assess clinical symptoms, in patients with PD who are given oral capsules plus IV infusions of NAC in addition to standard of care for PD for 6 months.

Trial Locations (1)

19107

Thomas Jefferson University, Marcus Institute of Integrative Health Centers, Philadelphia

All Listed Sponsors
lead

Thomas Jefferson University

OTHER