50
Participants
Start Date
April 30, 2020
Primary Completion Date
April 11, 2025
Study Completion Date
January 8, 2027
N acetyl cysteine
Intervention: IV NAC infusion: Dose: 50mg in 200ml of Dextrose 5% in Water (D5W), frequency: over one hour 1 x per week for 90 days ± 30 days AND Oral N-acetyl Cysteine - one 500 mg tablet 2 x per day (on days IV N-acetyl cysteine is not administered)
[F-18] Fluorodopa Positron Emission Tomography
FDOPA PET diagnostic imaging to to measure dopamine function, serum measures of NAC concentrations, magnetic resonance spectroscopy (MRS) to measure inflammatory and oxidative stress markers, and neurological measures to assess clinical symptoms, in patients with PD who are given oral capsules plus IV infusions of NAC in addition to standard of care for PD for 6 months.
Thomas Jefferson University, Marcus Institute of Integrative Health Centers, Philadelphia
Thomas Jefferson University
OTHER