Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

December 9, 2020

Primary Completion Date

August 15, 2023

Study Completion Date

August 15, 2023

Conditions
Metastatic Nasopharyngeal CarcinomaMetastatic Nasopharyngeal Keratinizing Squamous Cell CarcinomaMetastatic Nasopharyngeal Nonkeratinizing CarcinomaMetastatic Nasopharyngeal Undifferentiated CarcinomaNasopharyngeal Nonkeratinizing CarcinomaRecurrent Nasopharyngeal CarcinomaRecurrent Nasopharyngeal Keratinizing Squamous Cell CarcinomaRecurrent Nasopharyngeal Undifferentiated CarcinomaStage IV Nasopharyngeal Carcinoma AJCC v8Stage IVA Nasopharyngeal Carcinoma AJCC v8Stage IVB Nasopharyngeal Carcinoma AJCC v8
Interventions
DRUG

Carboplatin

Given IV

DRUG

Cisplatin

Given IV

DRUG

Gemcitabine

Given IV

BIOLOGICAL

Nivolumab

Given IV

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (325)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Lehigh Valley Hospital-Hazleton, Hazleton

18301

Pocono Medical Center, East Stroudsburg

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33028

Memorial Hospital West, Pembroke Pines

33308

Holy Cross Hospital, Fort Lauderdale

35233

University of Alabama at Birmingham Cancer Center, Birmingham

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

43210

Ohio State University Comprehensive Cancer Center, Columbus

44484

Saint Joseph Warren Hospital, Warren

44501

Saint Elizabeth Youngstown Hospital, Youngstown

44512

Saint Elizabeth Boardman Hospital, Boardman

45005

Dayton Physicians LLC-Atrium, Franklin

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Wayne Hospital, Greenville

45373

Dayton Physicians LLC - Troy, Troy

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC-Miami Valley Hospital North, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45431

Indu and Raj Soin Medical Center, Beavercreek

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

45505

Springfield Regional Medical Center, Springfield

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

47374

Reid Health, Richmond

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

Michigan Breast Specialists-Macomb Township, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China Township

48088

Advanced Breast Care Center PLLC, Warren

48093

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Macomb Hematology Oncology PC, Warren

Michigan Breast Specialists-Warren, Warren

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48114

Saint Joseph Mercy Brighton, Brighton

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

Hope Cancer Clinic, Livonia

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Saint Joseph Mercy Canton, Canton

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48236

Ascension Saint John Hospital, Detroit

Academic Hematology Oncology Specialists, Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods

48309

Great Lakes Cancer Management Specialists-Rochester Hills, Rochester Hills

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48341

21st Century Oncology-Pontiac, Pontiac

Hope Cancer Center, Pontiac

Newland Medical Associates-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48346

Hematology Oncology Consultants-Clarkston, Clarkston

Newland Medical Associates-Clarkston, Clarkston

48453

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

Caro Cancer Center, Caro

48764

Ascension Saint Joseph Hospital, Tawas City

48912

Sparrow Hospital, Lansing

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

Trinity Regional Medical Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51401

Saint Anthony Regional Hospital, Carroll

51503

Alegent Health Mercy Hospital, Council Bluffs

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

55905

Mayo Clinic in Rochester, Rochester

56187

Sanford Cancer Center Worthington, Worthington

56601

Sanford Joe Lueken Cancer Center, Bemidji

56701

Sanford Thief River Falls Medical Center, Thief River Falls

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58103

Sanford South University Medical Center, Fargo

Southpointe-Sanford Medical Center Fargo, Fargo

58104

Sanford Medical Center Fargo, Fargo

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60504

Rush - Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

Saint Anthony's Health, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

Capital Region Southwest Campus, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68114

Nebraska Methodist Hospital, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

CHI Health Saint Francis, Grand Island

68847

CHI Health Good Samaritan, Kearney

70805

LSU Health Baton Rouge-North Clinic, Baton Rouge

70809

Louisiana Hematology Oncology Associates LLC, Baton Rouge

Mary Bird Perkins Cancer Center, Baton Rouge

Our Lady of the Lake Physicians Group - Medical Oncology, Baton Rouge

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

77802

Saint Joseph Regional Cancer Center, Bryan

80122

Littleton Adventist Hospital, Littleton

80138

Parker Adventist Hospital, Parker

80210

Porter Adventist Hospital, Denver

80228

Saint Anthony Hospital, Lakewood

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Idaho Urologic Institute-Meridian, Meridian

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

85004

Cancer Center at Saint Joseph's, Phoenix

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Tumor Institute, Oakland

96701

Hawaii Cancer Care - Westridge, ‘Aiea

Pali Momi Medical Center, ‘Aiea

Queen's Cancer Center - Pearlridge, ‘Aiea

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Kuakini Medical Center, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

97814

Saint Alphonsus Medical Center-Baker City, Baker City

97914

Saint Alphonsus Medical Center-Ontario, Ontario

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

Harrison Medical Center, Bremerton

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

168583

National Cancer Centre Singapore, Singapore

94553-3156

Contra Costa Regional Medical Center, Martinez

32224-9980

Mayo Clinic in Florida, Jacksonville

50266-7700

Methodist West Hospital, West Des Moines

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

Unknown

Chinese University of Hong Kong-Prince of Wales Hospital, Shatin

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH