335
Participants
Start Date
August 19, 2020
Primary Completion Date
March 27, 2023
Study Completion Date
November 6, 2023
Olaparib
300 mg BID, oral until progressive disease or end of study
5-FU
2400 mg/m\^2 over 46 to 48 hours Q2W IV infusion until disease progression or end of study; bolus 5-FU (400mg/m2) can be added prior to infusional 5-FU, per local standards and at the investigator's discretion
Bevacizumab
5 mg/kg or 7.5 mg/kg Q2W or Q3W IV infusion until progressive disease or end of study
Capecitabine
1000 mg/m\^2 oral capsule BID for 14 days, then 7 days off, Q3W) until progressive disease or end of study
Leucovorin/ levoleucovorin
400 mg/m\^2 (leucovorin) or 200 mg/m\^2 (levoleucovorin) may be added to Bevacizumab + 5-FU per investigator's discretion Q2W IV infusion until progressive disease or end of study
Orszagos Onkologiai Intezet ( Site 1431), Budapest
UCL Saint Luc ( Site 0100), Brussels
Liverpool Hospital ( Site 0055), Liverpool
Sandton Oncology Medical Group PTY LTD ( Site 0900), Sandton
St George Hospital ( Site 0052), Kogarah
UZ Antwerpen ( Site 0108), Edegem
Imelda vzw ( Site 0110), Bonheiden
AZ Klina ( Site 0106), Brasschaat
UZ Gasthuisberg ( Site 0102), Leuven
Monash Health ( Site 0050), Clayton
Peninsula Health Frankston Hospital ( Site 0056), Frankston
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce, Miskolc
The Oncology Centre ( Site 0903), Durban
Royal Brisbane and Women s Hospital ( Site 0054), Herston
Debreceni Egyetem Klinikai Kozpont ( Site 1426), Debrecen
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1427), Szolnok
Queen Elizabeth Hospital ( Site 0053), Woodville South
Daugavpils Regional Hospital ( Site 1502), Daugavpils
Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 1432), Gyula
Cancercare Rondebosch Oncology ( Site 0904), Rondebosch
AZ Groeninge ( Site 0105), Kortrijk
Zala Megyei Szent Rafael Korhaz ( Site 1429), Zalaegerszeg
UZ Gent ( Site 0101), Ghent
OLV Ziekenhuis ( Site 0109), Aalst
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0504), Berlin
Allegheny Singer Research Institute ( Site 1364), Pittsburgh
Facharztzentrum Eppendorf ( Site 0501), Hamburg
Trakya Universitesi Tip Fakultesi ( Site 1210), Edirne
Blue Ridge Cancer Care ( Site 1374), Roanoke
CHU Jean Minjoz ( Site 0450), Besançon
Hospital Universitario Gregorio Maranon ( Site 1152), Madrid
Hospital 12 de Octubre de Madrid ( Site 1150), Madrid
University Cancer & Blood Center, LLC ( Site 1381), Athens
Hospital Universitario Central de Asturias ( Site 1153), Oviedo
CHU Bordeaux Haut-Leveque ( Site 0457), Pessac
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1202), Istanbul
CHU Saint Eloi ( Site 0467), Montpellier
Prof. Dr. Cemil Tascioglu Sehir Hastanesi ( Site 1216), Istanbul
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 1214), Istanbul
Kartal Dr. Lutfi Kirdar Egitim ve Arast Hast ( Site 1211), Istanbul
Ege Universitesi Tip Fakultesi Tulay Aktas Onkoloji Hastanesi ( Site 1204), Izmir
Vanderbilt University Medical Center ( Site 1362), Nashville
West Cancer Center - East Campus ( Site 1396), Germantown
Hattiesburg Clinic Hematology/Oncology ( Site 1418), Hattiesburg
James Graham Brown Cancer Center ( Site 1393), Louisville
Kyungpook National University Chilgok Hospital ( Site 0956), Daegu
Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 1203), Konya
Inonu Universitesi Medical Fakultesi ( Site 1207), Malatya
St. Josef und St. Elisabeth Hospital gGmbH-Hematology, oncology and palliative medicine ( Site 0503), Bochum
Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0455), Saint-Herblain
Medical center Medikal Plaza of Ecodnipro LLC ( Site 1317), Dnipro
Cancer & Hematology Centers of Western Michigan ( Site 1358), Grand Rapids
LSMUL Kauno Klinikos ( Site 1528), Kaunas
St. Vincent Frontier Cancer Center-Research ( Site 1414), Billings
University of Chicago ( Site 1357), Chicago
Communal non profit enterprise Regional Clinical Oncology Center ( Site 1304), Kharkiv
Illinois Cancer Care, PC ( Site 1352), Peoria
Washington University in St. Louis ( Site 1384), St Louis
C.H.U. de Strasbourg Hopital de Hautepierre ( Site 0464), Strasbourg
Cancer Partners of Nebraska ( Site 1353), Lincoln
CHI Health St. Francis ( Site 1406), Grand Island
Centre Leon Berard ( Site 0459), Lyon
Medical center of the Limited Liability Company Yulis ( Site 1314), Zaporizhzhia
University Medical Center New Orleans ( Site 1365), New Orleans
Hopital Europeen Georges Pompidou ( Site 0452), Paris
Baylor Scott & White Medical Center - Temple ( Site 1397), Temple
Poudre Valley Health System ( Site 1402), Fort Collins
UC Health Memorial Hospital ( Site 1401), Colorado Springs
Universitaetsklinikum Ulm ( Site 0500), Ulm
Providence Saint Joseph Medical Center, Disney Family Cancer ( Site 1392), Burbank
St Joseph Heritage Healthcare-Oncology ( Site 1383), Fullerton
Providence Portland Medical Center ( Site 1400), Portland
Oregon Health & Science University ( Site 1411), Portland
National Medical and Surgical Center n.a. N.I.Pirogov ( Site 1126), Moscow
Administradora Country SA - Clinica del Country ( Site 0350), Bogotá
Instituto Nacional de Cancerologia E.S.E ( Site 0362), Bogotá
N.N. Blokhin NMRCO ( Site 1106), Moscow
First Moscow State Medical University n.a. I.M.Sechenov ( Site 1127), Moscow
MROI n.a. P.A. Herzen - branch of FSBI NMICR of MoH of Russia ( Site 1128), Moscow
MEDSI Clinical Hospital on Pyatnitsky Highway-Departmentof Antitumor Drug therapy ( Site 1129), Krasnogorsk
Arkhangelsk Clinical Oncological Dispensary ( Site 1113), Arkhangelsk
City Clinical Oncology Center ( Site 1114), Saint Petersburg
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0353), Valledupar
Oncomedica S.A. ( Site 0352), Montería
GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 1130), Ufa
Oncologos del Occidente ( Site 0364), Pereira
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 1121), Krasnoyarsk
Fundacion Cardiovascular de Colombia ( Site 0360), Bucaramanga
Hemato Oncologos S.A. ( Site 0355), Santiago de Cali
National Cancer Center Hospital East ( Site 0650), Kashiwa
Centro Investigación del Cáncer James Lind ( Site 0251), Temuco
Sociedad Oncovida S.A. ( Site 0250), Santiago
Clínica San Carlos de Apoquindo Red Salud UC Christus ( Site 0252), Santiago
New England Cancer Specialists ( Site 1422), Scarborough
Dr. Everett Chalmers Regional Hospital ( Site 0204), Fredericton
Moncton Hospital - Horizon Health Network ( Site 0201), Moncton
Princess Margaret Cancer Centre ( Site 0209), Toronto
Hopital Cite de la Sante de Laval ( Site 0203), Laval
McGill University Health Centre ( Site 0207), Montreal
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0202), Sherbrooke
Aichi Cancer Center Hospital ( Site 0658), Nagoya
National Hospital Organization Shikoku Cancer Center ( Site 0652), Matsuyama
St. Marianna University School of Medicine Hospital ( Site 0657), Kawasaki
Saitama Cancer Center ( Site 0653), Kitaadachi-gun
Shizuoka Cancer Center Hospital and Research Institute ( Site 0655), Sunto-gun
Chiba Cancer Center ( Site 0656), Chiba
National Hospital Organization Kyushu Cancer Center ( Site 0654), Fukuoka
National Cancer Center Hospital ( Site 0651), Tokyo
The Cancer Institute Hospital of JFCR ( Site 0659), Tokyo
P. Stradina Clinical University Hospital ( Site 1500), Riga
Riga East Clinical University Hospital ( Site 1501), Riga
Nacionalinis Vezio Institutas ( Site 1527), Vilnius
Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 1526), Vilnius
Asan Medical Center ( Site 0952), Songpagu
Korea University Anam Hospital ( Site 0955), Seoul
Seoul National University Hospital ( Site 0950), Seoul
Severance Hospital Yonsei University Health System ( Site 0951), Seoul
Samsung Medical Center ( Site 0954), Seoul
The Catholic University of Korea St. Mary s Hospital ( Site 0953), Seoul
Hospital General Universitario de Elche ( Site 1155), Elche
Hospital Vall D Hebron ( Site 1151), Barcelona
Baskent University Adana Training Hospital ( Site 1205), Adana
Hacettepe University Faculty of Medicine ( Site 1200), Ankara
Gazi Universitesi Tip Fakultesi ( Site 1215), Ankara
Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 1319), Kapitanivka Village
Medical Center Asklepion LLC ( Site 1309), Khodosovka
Medical Center Verum ( Site 1318), Kyiv
Shalimov s NI of Surgery and Transplantation ( Site 1321), Kyiv
Dobrobut Medical Center ( Site 1320), Kyiv
Collaborators (1)
AstraZeneca
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY