61
Participants
Start Date
October 14, 2021
Primary Completion Date
March 15, 2026
Study Completion Date
September 30, 2027
Enzalutamide
Given PO
Rucaparib camsylate
Given PO
Placebo
Given PO
Leuprolide Acetate
Given IM
Goserelin Acetate
Given SC
Degarelix
Given SC
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
NYP/Weill Cornell Medical Center, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Montefiore Medical Center-Weiler Hospital, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
Nyack Hospital, Nyack
The New York Hospital Medical Center of Queens, Flushing
Queens Hospital Center, Jamaica
Glens Falls Hospital, Glens Falls
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Lehigh Valley Hospital-Cedar Crest, Allentown
Lehigh Valley Hospital-Hazleton, Hazleton
Pocono Medical Center, East Stroudsburg
Guthrie Medical Group PC-Robert Packer Hospital, Sayre
Thomas Jefferson University Hospital, Philadelphia
MedStar Washington Hospital Center, Washington D.C.
George Washington University Medical Center, Washington D.C.
Shenandoah Oncology PC, Winchester
Virginia Cancer Institute, Richmond
Virginia Commonwealth University/Massey Cancer Center, Richmond
VCU Community Memorial Health Center, South Hill
Centra Lynchburg Hematology-Oncology Clinic Inc, Lynchburg
West Virginia University Charleston Division, Charleston
Wake Forest University at Clemmons, Clemmons
Wake Forest University Health Sciences, Winston-Salem
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
Southeastern Medical Oncology Center-Clinton, Clinton
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
Wake Forest Baptist Health - Wilkes Medical Center, Wilkesboro
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Greenville Memorial Hospital, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Easley, Easley
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Saint Joseph's/Candler - Bluffton Campus, Bluffton
Augusta Oncology Associates PC-D'Antignac, Augusta
Augusta Oncology Associates PC-Wheeler, Augusta
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
Mount Sinai Medical Center, Miami Beach
Mount Sinai Comprehensive Cancer Center at Aventura, Aventura
Holy Cross Hospital, Fort Lauderdale
Flaget Memorial Hospital, Bardstown
Jewish Hospital Medical Center South, Shepherdsville
Jewish Hospital, Louisville
Saints Mary and Elizabeth Hospital, Louisville
UofL Health Medical Center Northeast, Louisville
Saint Joseph Radiation Oncology Resource Center, Lexington
Saint Joseph Hospital East, Lexington
Commonwealth Cancer Center-Corbin, Corbin
Saint Joseph London, London
Ohio State University Comprehensive Cancer Center, Columbus
ProMedica Flower Hospital, Sylvania
Mercy Health - Saint Anne Hospital, Toledo
Toledo Clinic Cancer Centers-Toledo, Toledo
Cleveland Clinic Foundation, Cleveland
Dayton Physicians LLC-Atrium, Franklin
Good Samaritan Hospital - Cincinnati, Cincinnati
Bethesda North Hospital, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
TriHealth Cancer Institute-Anderson, Cincinnati
Miami Valley Hospital, Dayton
Greater Dayton Cancer Center, Kettering
Dayton Physician LLC-Miami Valley Hospital North, Dayton
Miami Valley Hospital North, Dayton
Kettering Medical Center, Kettering
Dayton Physicians LLC-Miami Valley South, Centerville
Miami Valley Hospital South, Centerville
Springfield Regional Cancer Center, Springfield
Armes Family Cancer Center, Findlay
Memorial Hospital of South Bend, South Bend
Reid Health, Richmond
Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb
Michigan Breast Specialists-Macomb Township, Macomb
Great Lakes Cancer Management Specialists-Doctors Park, East China
Advanced Breast Care Center PLLC, Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren
Macomb Hematology Oncology PC, Warren
Michigan Breast Specialists-Warren, Warren
Saint John Macomb-Oakland Hospital, Warren
Saint Joseph Mercy Hospital, Ann Arbor
Huron Gastroenterology PC, Ypsilanti
Saint Joseph Mercy Brighton, Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
Saint Joseph Mercy Chelsea, Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
Hope Cancer Clinic, Livonia
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Toledo Clinic Cancer Centers-Monroe, Monroe
Saint Joseph Mercy Canton, Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
Ascension Saint John Hospital, Detroit
Academic Hematology Oncology Specialists, Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods
Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights
21st Century Oncology-Pontiac, Pontiac
Hope Cancer Center, Pontiac
Newland Medical Associates-Pontiac, Pontiac
Saint Joseph Mercy Oakland, Pontiac
Hematology Oncology Consultants-Clarkston, Clarkston
Newland Medical Associates-Clarkston, Clarkston
Saint Mary's Oncology/Hematology Associates of Marlette, Marlette
Genesee Cancer and Blood Disease Treatment Center, Flint
Genesee Hematology Oncology PC, Flint
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
Ascension Saint Mary's Hospital, Saginaw
Oncology Hematology Associates of Saginaw Valley PC, Saginaw
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch
Caro Cancer Center, Caro
Ascension Saint Joseph Hospital, Tawas City
Sparrow Hospital, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Ascension Borgess Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Marie Yeager Cancer Center, Saint Joseph
Hickman Cancer Center, Adrian
Trinity Health Muskegon Hospital, Muskegon
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
Spectrum Health at Butterworth Campus, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Spectrum Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Mary Greeley Medical Center, Ames
McFarland Clinic - Ames, Ames
McFarland Clinic - Boone, Boone
McFarland Clinic - Jefferson, Jefferson
McFarland Clinic - Marshalltown, Marshalltown
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
Medical Oncology and Hematology Associates-Des Moines, Des Moines
Broadlawns Medical Center, Des Moines
Mercy Medical Center - Des Moines, Des Moines
Mission Cancer and Blood - Laurel, Des Moines
Iowa Lutheran Hospital, Des Moines
Medical Oncology and Hematology Associates-West Des Moines, Clive
Mercy Cancer Center-West Lakes, Clive
McFarland Clinic - Trinity Cancer Center, Fort Dodge
Trinity Regional Medical Center, Fort Dodge
Greater Regional Medical Center, Creston
Saint Anthony Regional Hospital, Carroll
Alegent Health Mercy Hospital, Council Bluffs
Aurora Health Care Germantown Health Center, Germantown
Aurora Cancer Care-Grafton, Grafton
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Aurora Cancer Care-Southern Lakes VLCC, Burlington
Aurora Cancer Care-Kenosha South, Kenosha
ProHealth D N Greenwald Center, Mukwonago
ProHealth Waukesha Memorial Hospital, Waukesha
UW Cancer Center at ProHealth Care, Waukesha
Aurora Cancer Care-Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Aurora Cancer Care-Racine, Racine
University of Wisconsin Carbone Cancer Center, Madison
Aurora Bay Area Medical Group-Marinette, Marinette
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Clinic-Minocqua Center, Minocqua
Gundersen Lutheran Medical Center, La Crosse
Mayo Clinic Health System-Franciscan Healthcare, La Crosse
Marshfield Medical Center-EC Cancer Center, Eau Claire
Mayo Clinic Health System-Eau Claire Clinic, Eau Claire
Duluth Clinic Ashland, Ashland
Marshfield Medical Center-Rice Lake, Rice Lake
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Essentia Health Sandstone, Sandstone
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Minneapolis VA Medical Center, Minneapolis
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Essentia Health Hibbing Clinic, Hibbing
Essentia Health Virginia Clinic, Virginia
Essentia Health Cancer Center, Duluth
Saint Luke's Hospital of Duluth, Duluth
Sanford Cancer Center Worthington, Worthington
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
Essentia Health Saint Joseph's Medical Center, Brainerd
Sanford Joe Lueken Cancer Center, Bemidji
Essentia Health - Deer River Clinic, Deer River
Sanford Thief River Falls Medical Center, Thief River Falls
Avera Cancer Institute at Yankton, Yankton
Sanford Cancer Center Oncology Clinic, Sioux Falls
Avera Cancer Institute, Sioux Falls
Avera Cancer Institute-Aberdeen, Aberdeen
Essentia Health Cancer Center-South University Clinic, Fargo
Sanford South University Medical Center, Fargo
Southpointe-Sanford Medical Center Fargo, Fargo
Sanford Medical Center Fargo, Fargo
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Benefis Healthcare- Sletten Cancer Institute, Great Falls
Great Falls Clinic, Great Falls
Community Hospital of Anaconda, Anaconda
Bozeman Deaconess Hospital, Bozeman
Saint Patrick Hospital - Community Hospital, Missoula
Community Medical Hospital, Missoula
Kalispell Regional Medical Center, Kalispell
Northwestern Medicine Lake Forest Hospital, Lake Forest
Advocate Lutheran General Hospital, Park Ridge
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Northwestern Medicine Cancer Center Delnor, Geneva
Loyola University Medical Center, Maywood
Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park
West Suburban Medical Center, River Forest
Ingalls Memorial Hospital, Harvey
Loyola Medicine Homer Glen, Homer Glen
Rush - Copley Medical Center, Aurora
Loyola Center for Health at Burr Ridge, Burr Ridge
Northwestern Medicine Cancer Center Warrenville, Warrenville
Rush-Copley Healthcare Center, Yorkville
Northwestern University, Chicago
Rush University Medical Center, Chicago
University of Illinois, Chicago
Advocate Illinois Masonic Medical Center, Chicago
Illinois CancerCare-Dixon, Dixon
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Valley Radiation Oncology, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Western Illinois Cancer Treatment Center, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare - Washington, Washington
Illinois CancerCare-Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
Illinois CancerCare-Bloomington, Bloomington
Carle Cancer Center, Urbana
The Carle Foundation Hospital, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
Cancer Care Center of O'Fallon, O'Fallon
Illinois CancerCare-Carthage, Carthage
Carle Physician Group-Effingham, Effingham
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Memorial Medical Center, Springfield
Centralia Oncology Clinic, Centralia
Memorial Hospital of Carbondale, Carbondale
SIH Cancer Institute, Carterville
Missouri Baptist Sullivan Hospital, Sullivan
Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills
Missouri Baptist Medical Center, St Louis
Mercy Hospital Saint Louis, St Louis
Parkland Health Center - Farmington, Farmington
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
Saint Francis Medical Center, Cape Girardeau
Southeast Cancer Center, Cape Girardeau
Capital Region Southwest Campus, Jefferson City
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
Midlands Community Hospital, Papillion
Alegent Health Immanuel Medical Center, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Creighton University Medical Center, Omaha
Saint Elizabeth Regional Medical Center, Lincoln
CHI Health Saint Francis, Grand Island
CHI Health Good Samaritan, Kearney
CHI Saint Vincent Cancer Center Hot Springs, Hot Springs
University of Oklahoma Health Sciences Center, Oklahoma City
Cancer Centers of Southwest Oklahoma Research, Lawton
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Ben Taub General Hospital, Houston
Michael E DeBakey VA Medical Center, Houston
Saint Joseph Regional Cancer Center, Bryan
Littleton Adventist Hospital, Littleton
Parker Adventist Hospital, Parker
Porter Adventist Hospital, Denver
Saint Anthony Hospital, Lakewood
Longmont United Hospital, Longmont
Rocky Mountain Cancer Centers-Longmont, Longmont
Penrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Mary Corwin Medical Center, Pueblo
Mercy Medical Center, Durango
Southwest Oncology PC, Durango
Billings Clinic-Cody, Cody
Welch Cancer Center, Sheridan
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Walter Knox Memorial Hospital, Emmett
Saint Luke's Cancer Institute - Fruitland, Fruitland
Idaho Urologic Institute-Meridian, Meridian
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Kootenai Health - Coeur d'Alene, Coeur d'Alene
Kootenai Clinic Cancer Services - Post Falls, Post Falls
Kootenai Cancer Clinic, Sandpoint
Huntsman Cancer Institute/University of Utah, Salt Lake City
Cancer Center at Saint Joseph's, Phoenix
University of New Mexico Cancer Center, Albuquerque
Presbyterian Kaseman Hospital, Albuquerque
Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho
OptumCare Cancer Care at Charleston, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
Sharp Memorial Hospital, San Diego
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
Mission Hope Medical Oncology - Santa Maria, Santa Maria
Kaiser Permanente-Fresno, Fresno
Kaiser Permanente-South San Francisco, South San Francisco
Kaiser Permanente-San Francisco, San Francisco
Kaiser Permanente-Deer Valley Medical Center, Antioch
Kaiser Permanente-Fremont, Fremont
Kaiser Permanente Dublin, Dublin
Saint Helena Hospital, St. Helena
Kaiser Permanente San Leandro, San Leandro
Kaiser Permanente-Vallejo, Vallejo
Kaiser Permanente-Walnut Creek, Walnut Creek
Kaiser Permanente-Oakland, Oakland
Kaiser Permanente-Richmond, Richmond
Kaiser San Rafael-Gallinas, San Rafael
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Kaiser Permanente-Santa Teresa-San Jose, San Jose
Kaiser Permanente-Stockton, Stockton
Kaiser Permanente-Modesto, Modesto
Kaiser Permanente-Santa Rosa, Santa Rosa
Kaiser Permanente-Roseville, Roseville
Northbay Cancer Center, Vacaville
Kaiser Permanente Medical Center-Vacaville, Vacaville
Kaiser Permanente Downtown Commons, Sacramento
Kaiser Permanente-South Sacramento, Sacramento
Pali Momi Medical Center, ‘Aiea
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu
Queen's Cancer Cenrer - POB I, Honolulu
Queen's Medical Center, Honolulu
Straub Clinic and Hospital, Honolulu
Queen's Cancer Center - Kuakini, Honolulu
Kaiser Permanente Moanalua Medical Center, Honolulu
Clackamas Radiation Oncology Center, Clackamas
Providence Cancer Institute Clackamas Clinic, Clackamas
Providence Newberg Medical Center, Newberg
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Bay Area Hospital, Coos Bay
Saint Charles Health System, Bend
Saint Charles Health System-Redmond, Redmond
Saint Alphonsus Medical Center-Baker City, Baker City
Saint Alphonsus Medical Center-Ontario, Ontario
Saint Francis Hospital, Federal Way
FHCC Overlake, Bellevue
Saint Elizabeth Hospital, Enumclaw
Swedish Cancer Institute-Edmonds, Edmonds
Swedish Cancer Institute-Issaquah, Issaquah
Seattle Cancer Care Alliance at EvergreenHealth, Kirkland
Valley Medical Center, Renton
Pacific Gynecology Specialists, Seattle
Swedish Medical Center-Ballard Campus, Seattle
Swedish Medical Center-First Hill, Seattle
FHCC at Northwest Hospital, Seattle
Highline Medical Center-Main Campus, Burien
Providence Regional Cancer Partnership, Everett
PeaceHealth Saint Joseph Medical Center, Bellingham
PeaceHealth United General Medical Center, Sedro-Woolley
Harrison Medical Center, Bremerton
Jefferson Healthcare, Port Townsend
Franciscan Research Center-Northwest Medical Plaza, Tacoma
Saint Clare Hospital, Lakewood
Providence Regional Cancer System-Lacey, Lacey
Anchorage Associates in Radiation Medicine, Anchorage
Providence Regional Cancer System-Aberdeen, Aberdeen
Providence Regional Cancer System-Centralia, Centralia
Providence Regional Cancer System-Shelton, Shelton
Providence Regional Cancer System-Yelm, Yelm
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
Kadlec Clinic Hematology and Oncology, Kennewick
Providence Saint Mary Regional Cancer Center, Walla Walla
Anchorage Radiation Therapy Center, Anchorage
Alaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Oncology Centre, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven
Methodist West Hospital, West Des Moines
Harold Alfond Center for Cancer Care, Augusta
New Hampshire Oncology Hematology PA-Concord, Concord
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Solinsky Center for Cancer Care, Manchester
Hackensack University Medical Center, Hackensack
Saint Joseph's Regional Medical Center, Paterson
South Carolina Cancer Specialists PC, Hilton Head Island
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Norris Cotton Cancer Center-North, Saint Johnsbury
Swedish Medical Center-Cherry Hill, Seattle
National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER