The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge

NACompletedINTERVENTIONAL
Enrollment

382

Participants

Timeline

Start Date

July 1, 2021

Primary Completion Date

December 2, 2022

Study Completion Date

December 2, 2022

Conditions
Hypersensitivity, ImmediateHypersensitivity, DelayedHypersensitivity Response
Interventions
OTHER

Direct oral penicillin challenge

The patient will receive a single dose of oral penicillin, following baseline vital signs.

OTHER

Standard of care

Routine management as per the treating clinicians that include skin prick and intradermal beta-lactam testing, followed by oral penicillin challenge in the setting of negative skin testing.

Trial Locations (6)

3000

Peter MacCallum Cancer Center, Melbourne

Royal Melbourne Hospital, Melbourne

3084

Austin Health, Heidelberg

27710

Duke University Medical Center, Durham

37232

Vanderbilt University Medical Center, Nashville

H3G 1A4

McGill University Health Centre (MUHC), Montreal

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Austin Health

OTHER_GOV