A Study of the Safety of Oral Elsubrutinib Capsules and Oral Upadacitinib Tablets Given Alone or in Combination (ABBV-599) for Adult Participants With Moderately to Severely Active Systemic Lupus Erythematosus to Assess Change in Disease State

PHASE2CompletedINTERVENTIONAL
Enrollment

185

Participants

Timeline

Start Date

July 27, 2020

Primary Completion Date

January 3, 2024

Study Completion Date

January 3, 2024

Conditions
Systemic Lupus Erythematosus (SLE)
Interventions
DRUG

Elsubrutinib

Capsule; Oral

DRUG

Placebo for Elsubrutinib

Capsule; Oral

DRUG

Upadacitinib

Film-coated tablet; Oral

DRUG

Placebo for Upadacitinib

Film-coated tablet; Oral

Trial Locations (87)

100

National Taiwan University Hospital /ID# 221745, Taipei City

333

Linkou Chang Gung Memorial Hospital /ID# 222469, Taoyuan

1426

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 222569, Ciudad Autonoma Buenos Aires

1431

UMHAT Sveti Ivan Rilski /ID# 223358, Sofia

UMHAT Sveti Ivan Rilski /ID# 223359, Sofia

1878

CER Instituto Medico /ID# 223175, Quilmes

1900

Hospital Interzonal General de Agudos General Jose de San Martin /ID# 221893, La Plata

1958

Aprillus Asistencia e Investigacion /ID# 221890, Ciudad Autonoma de Buenos Aire

2000

Instituto CAICI S.R.L /ID# 221892, Rosario

3124

Emeritus Research /ID# 223027, Camberwell

3168

Monash Medical Centre /ID# 221814, Clayton

4000

Centro de Investigaciones Medicas Tucuman /ID# 221888, San Miguel de Tucumán

Investigaciones Clinicas Tucuman /ID# 221889, San Miguel de Tucumán

4032

Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 222480, Debrecen

4558

Rheumatology Research Unit Sunshine Coast /ID# 221816, Maroochydore

8200

Vital Medicina Kft /ID# 222479, Veszprém

10117

Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 222963, Berlin

11031

Taipei Medical University Hospital /ID# 227653, Taipei

11217

Taipei Veterans General Hosp /ID# 221746, Taipei

11850

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 221913, Mexico City

15006

Duplicate_Hospital Universitario A Coruna - CHUAC /ID# 221993, A Coruña

15224

Allegheny Health Network Research Institute /ID# 245086, Pittsburgh

20902

The Center for Rheumatology and Bone Research /ID# 225479, Wheaton

24016

Carilion Clinic /ID# 227832, Roanoke

28041

Hospital Universitario 12 de Octubre /ID# 221994, Madrid

32174

Millennium Research /ID# 233192, Ormond Beach

33180

Duplicate_Arthritis & Rheumatic Disease Specialties /ID# 227828, Aventura

33324

IRIS Research and Development, LLC /ID# 227814, Plantation

37000

Morales Vargas Centro de Investigacion S.C. /ID# 221912, León

38119

Dr. Ramesh Gupta /ID# 225524, Memphis

40447

China Medical University Hospital /ID# 221747, Taichung

40705

Taichung Veterans General Hospital /ID# 221748, Taichung

41014

Hospital Universitario Virgen de Valme /ID# 221997, Seville

44124

Duplicate_Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant Anna /ID# 221919, Cona

44160

Centro Integral en Reumatologia S.A de C.V /ID# 221914, Guadalajara

44690

Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 221910, Guadalajara

46026

Hospital Universitario y Politecnico La Fe /ID# 221998, Valencia

48013

Hospital Universitario Basurto /ID# 221999, Bilbao

48911

June DO, PC /ID# 221841, Lansing

48960

Hospital Universitario de Galdakao /ID# 221996, Galdakao

60048

Deerbrook Medical Associates /ID# 227330, Libertyville

75150

SW Rheumatology Res. LLC /ID# 225485, Mesquite

77084

Accurate Clinical Management /ID# 225509, Houston

78745

Tekton Research, Inc. /ID# 224411, Austin

80002

Duplicate_Centro Integral de Reumatologia del Caribe Circaribe SAS /ID# 221879, Barranquilla

80045

University of Colorado Hospital /ID# 245087, Aurora

90211

Wallace Rheumatic Studies Center, LLC /ID# 224374, Beverly Hills

94578

East Bay Rheumatology Medical /ID# 225493, San Leandro

97070

Medical Care & Research SA de CV /ID# 221911, Mérida

100730

Duplicate_Peking Union Medical College Hospital /ID# 222950, Beijing

110221

Duplicate_Centro de Investigacion en Reumatologia y Especialidades Medicas- CIRE /ID# 221884, Bogota

200040

Huashan Hospital, Fudan University /ID# 222929, Shanghai

250001

Preventive Care Sas /Id# 221881, Chía

250252

Healthy Medical Center S.A.S /ID# 221882, Zipaquirá

510080

Guangdong Provincial People's Hospital /ID# 222851, Guangzhou

830001

People's Hospital of Xinjiang /ID# 222928, Urumqi

9808574

Tohoku University Hospital /ID# 222392, Sendai

85032-9306

Duplicate_AZ Arthritis and Rheumotology Research, PLLC /ID# 227833, Phoenix

90720-5402

Valerius Medical Group & Research Center /ID# 223922, Los Alamitos

47714-0805

Qualmedica Research, LLC /ID# 227817, Evansville

02215-5400

Beth Israel Deaconess Medical Center /ID# 222505, Boston

10016-2772

Duplicate_NYU Langone Health/NYU School of Medicine /ID# 245088, New York

45377-9464

STAT Research, Inc. /ID# 221840, Vandalia

050034

Clinica Universitaria Bolivari /ID# 221880, Medellin

01307

Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 222964, Dresden

457-8510

Chukyo Hospital /ID# 223398, Nagoya

460-0001

NHO Nagoya Medical Center /ID# 222397, Nagoya

807-8556

Hospital of the University of Occupational and Environmental Health, Japan /ID# 222499, Kitakyushu-shi

730-8619

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 222393, Hiroshima

070-8644

National Hospital Organization Asahikawa Medical Center /ID# 222394, Asahikawa-shi

890-0063

EIRAKU Internal Medicine Clinic /ID# 222385, Kagoshima

390-8621

Shinshu University Hospital /ID# 222395, Matsumoto-shi

350-8550

Saitama Medical Center /ID# 222389, Kawagoe-shi

160-8582

Keio University Hospital /ID# 222498, Shinjuku-ku

03100

RM Pharma Specialists S.A de C.V. /ID# 221915, Mexico City

0622

North Shore Hospital /ID# 221850, Takapuna

61-545

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 221859, Poznan

31-011

Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 224430, Krakow

51-685

WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 221860, Wroclaw

02-172

MTZ Clinical Research Powered by Pratia /ID# 224431, Warsaw

00917-3104

GCM Medical Group PSC /ID# 224394, San Juan

00918-3756

Mindful Medical Research /ID# 222513, San Juan

03080

Seoul National University Hospital /ID# 221897, Seoul

01009

HUA - Txagorritxu /ID# 221992, Vitoria-Gasteiz

08208

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 221995, Sabadell

SE1 9RT

Guys and St Thomas NHS Foundation Trust /ID# 221863, London

M13 9WL

Duplicate_Manchester University NHS Foundation Trust /ID# 221861, Manchester

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INDUSTRY