A Study to Compare SB15 (Proposed Aflibercept Biosimilar) to Eylea in Subjects With Neovascular Age-related Macular Degeneration (AMD)

PHASE3CompletedINTERVENTIONAL
Enrollment

449

Participants

Timeline

Start Date

June 23, 2020

Primary Completion Date

April 15, 2021

Study Completion Date

March 16, 2022

Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG

SB15 (Proposed aflibercept biosimilar)

Subjects randomized into SB15 group will receive SB15 2 mg (0.05 mL) via intravitreal injection every 4 weeks for the first 3 months, followed by 2 mg (0.05 mL) once every 8 weeks until Week 48. Starting at Week 32, subjects transited from Eylea to SB15 will receive SB15 2 mg (0.05 mL) via intravitreal injection every 8 weeks.

DRUG

Eylea (Aflibercept)

Subjects randomized into Eylea group will receive Eylea 2 mg (0.05 mL) via intravitreal injection every 4 weeks for the first 3 months, followed by 2 mg (0.05 mL) once every 8 weeks until Week 48.

Trial Locations (38)

20815

SB Investigative Site, Chevy Chase

79606

SB Investigative Site, Abilene

80909

SB Investigative Site, Colorado Springs

Unknown

SB Investigative Site, Osijek

SB Investigative Site, Rijeka

SB Investigative Site, Brno

SB Investigative Site, Hradec Králové

SB Investigative Site, Prague

SB Investigative Site, Kohtla-Järve

SB Investigative Site, Tallinn

SB Investigative Site, Budapest

SB Investigative Site, Debrecen

SB Investigative Site, Pécs

SB Investigative Site, Szeged

SB Investigative Site, Zalaegerszeg

SB Investigative Site, Aichi

SB Investigative Site, Fukuoka

SB Investigative Site, Inashiki-gun

SB Investigative Site, Kagoshima

SB Investigative Site, Nagasaki

SB Investigative Site, Osaka

SB Investigative Site, Saitama

SB Investigative Site, Tokyo

SB Investigative Site, Riga

SB Investigative Site, Bydgoszcz

SB Investigative Site, Katowice

SB Investigative Site, Krakow

SB Investigative Site, Lodz

SB Investigative Site, Tarnów

SB Investigative Site, Kovrov

SB Investigative Site, Moscow

SB Investigative Site, Novosibirsk

SB Investigative Site, Saint Petersburg

SB Investigative Site, Ansan

SB Investigative Site, Busan

SB Investigative Site, Daegu

SB Investigative Site, Seongnam

SB Investigative Site, Seoul

All Listed Sponsors
lead

Samsung Bioepis Co., Ltd.

INDUSTRY

NCT04450329 - A Study to Compare SB15 (Proposed Aflibercept Biosimilar) to Eylea in Subjects With Neovascular Age-related Macular Degeneration (AMD) | Biotech Hunter | Biotech Hunter