Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia

PHASE2CompletedINTERVENTIONAL
Enrollment

122

Participants

Timeline

Start Date

May 27, 2021

Primary Completion Date

December 12, 2024

Study Completion Date

January 15, 2025

Conditions
Bronchopulmonary Dysplasia of Newborn
Interventions
DRUG

Sildenafil

Sildenafil citrate injection or powder for suspension

DRUG

Placebo

dextrose 5%

Trial Locations (25)

10595

Westchester Medical Center - New York Medical College, Valhalla

14642

University of Rochester School of Medicine Children's Hospital, Rochester

20010

Childrens National Medical Center, Washington D.C.

27157

Wake Forest University Health Sciences, Winston-Salem

27599

University of NC at Chapel Hill, Chapel Hill

27858

East Carolina University, Greenville

30322

Emory Children's Center, Atlanta

32209

University of Florida Jacksonville Shands Medical Center, Jacksonville

Wolfson Children's Hospital, Jacksonville

38163

University of Tennessee Health Science Center, Memphis

39216

University of Mississippi Medical Center, Jackson

40202

University of Louisville School of Medicine, Louisville

40506

University of Kentucky Chandler Medical Center, Lexington

44106

Rainbow Babies and Childrens Hospital, Cleveland

60611

University of Illinois at Chicago, Chicago

64108

Childrens Mercy Hospital, Kansas City

70115

Ochsner Baptist Medical Center, New Orleans

72202

Arkansas Children's Research Institute, Little Rock

72205

University of Arkansas Medical Sciences, Little Rock

77054

Women's Hospital of Texas, Houston

78723

University of Texas Health, Austin

89102

Children's Hospital of Nevada at University Medical Center, Las Vegas

92123

Rady Children's Hospital and Health Center, San Diego

60611-2605

Lurie Children's Hospital, Chicago

02115

Boston Children's Hospital, Boston

All Listed Sponsors
collaborator

University of North Carolina, Chapel Hill

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Christoph Hornik

OTHER