Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

575

Participants

Timeline

Start Date

June 30, 2020

Primary Completion Date

April 19, 2024

Study Completion Date

October 16, 2026

Conditions
Metastatic Prostate CancerProstate Adenocarcinoma
Interventions
DRUG

Cabozantinib

Supplied as 20-mg tablets; administered orally daily at 40mg

DRUG

Atezolizumab

Supplied as 1200 mg/20 mL vials; administered as an IV infusion once every 3 weeks (q3w)

DRUG

Abiraterone Acetate

Supplied as 500 mg tablets; administered orally daily at 1000mg with prednisone 5 mg orally bid

DRUG

Enzalutamide

Supplied as 40 mg capsules; administered orally daily at 160mg

DRUG

Prednisone

Supplied as 5 mg tablets; administered orally bid at 5 mg with abiraterone 1000mg orally daily

Trial Locations (279)

333

Exelixis Clinical #265, Taoyuan District

404

Exelixis Clinical Site #86, Taichung

407

Exelixis Clinical Site #133, Taichung

704

Exelixis Clinical Site #111, Tainan City

710

Exelixis Clinical Site #271, Tainan City

833

Exelixis Clinical Site #138, Kaohsiung City

1000

Exelixis Clinical Site #141, Brussels

1062

Exelixis Clinical Site #118, Budapest

1080

Exelixis Clinical Site #218, Vienna

1082

Exelixis Clinical Site #207, Budapest

1122

Exelixis Clinical Site #57, Budapest

1145

Exelixis Clinical Site #109, Budapest

2065

Exelixis Clinical Site #175, Saint Leonards

2109

Exelixis Clinical Site # 189, Sydney

2444

Exelixis Clinical Site #252, Port Macquarie

2500

Exelixis Site #162, Wollongong

2605

Exelixis Clinical Site #151, Garran

2820

Exelixis Clinical Site #126, Bonheiden

3000

Exelixis Clinical Site #53, Melbourne

3021

Exelixis Clinical Stie #260, Saint Albans

3128

Exelixis Clinical Site #149, Box Hill

3199

Exelixis Clinical Site #95, Frankston

3220

Exelixis Clinical #262, Geelong

3350

Exelixis Clinical Site #79, Ballarat

4020

Exelixis Clinical Site #156, Linz

Exelixis Site #158, Linz

4032

Exelixis Clinical Site #253, Chermside

Exelixis Clinical Site #240, Debrecen

5000

Exelixis Clinical Site #115, Adelaide

5400

Exelixis Clinical Site #124, San Juan

5700

Exelixis site #167, Gyula

7250

Exelixis Clinical Site #103, Launceston

8800

Exelixis Site #165, Roeselare

9000

Exelixis Clinical Site #39, Ghent

10065

Weill Cornell Medical College, New York

10117

Exelixis Clinical Site #227, Berlin

10408

Exelixis Clinical Site #49, Goyang-si

10461

Exelixis Clinical Site #198, The Bronx

11217

Exelixis Clinical #264, Taipei

11407

Exelixis Clinical Site #226, Cadiz

11526

Exelixis Clinical Site #238, Athens

13620

Exelixis Clinical Site #60, Seongnam-si

14004

Exelixis Clinical Site #33, Córdoba

14564

Exelixis Clinical Site #244, Nea Kifissia

15123

Exelixis Clinical Site #202, Marousi

15125

Exelixis Clinical Site #92, Marousi

15232

Exelixis Clinical Site #201, Pittsburgh

15562

Exelixis Clinical Site #93, Cholargós

15706

Exelixis Clinical Site #233, Santiago de Compostela

18547

Exelixis Clinical Site #99, Neo Faliro

19111

Exelixis Clinical Site #18, Philadelphia

20089

Exelixis Clinical Site #246, Rozzano

20132

Exelixis Clinical Site #192, Milan

20133

Exelixis Clinical Site #258, Milan

20246

Exelixis Clinical Site #239, Hamburg

21079

Exelixis Clinical Site #155, Dijon

21204

Exelixis Clinical Site #6, Baltimore

23100

Exelixis Site #156, Sondrio

23538

Exelixis Clinical Site #185, Lübeck

24014

Exelixis Clinical Site #143, Roanoke

27003

Exelixis Clinical Site #28, Lugo

27100

Exelixis Clinical Site #237, Pavia

28033

Exelixis Clinical Site #131, Madrid

28040

Exelixis Clinical Site #248, Madrid

28041

Exelixis Clinical Site #236, Madrid

28046

Exelixis Clinical Site #251, Madrid

28050

Exelixis Clinical Site #13, Madrid

28922

Exelixis Clinical Site #17, Alcorcón

29010

Exelixis Clinical #270, Málaga

29038

Exelixis Clinical Site #206, Tuxtla Gutiérrez

29107

Exelixis Clinical Site #66, Quimper

29229

Exelixis Clinical Site #134, Brest

30029

Exelixis Clinical Site #146, Nîmes

30322

Winship Cancer Institute of Emory University, Atlanta

30625

Exelixis Clinical Site #273, Hanover

31059

Exelixis Clinical Site #73, Toulouse

31076

Exelixis Clinical Site #85, Toulouse

33011

Exelixis Clinical Site #225, Oviedo

33125

Exelixis Clinical Site #108, Miami

33332

Exelixis Clinical Site #98, Gütersloh

35015

Exelixis Clinical Site #20, Junggu

35760

Exelixis Clinical Site #135, Saint-Grégoire

37178

Exelixis Clinical Site #254, León

37209

Exelixis Clinical Site #1, Nashville

38122

Exelixis Clinical Site #199, Trento

40202

Exelixis Clinical Site #242, Louisville

41009

Exelixis Clinical Site #29, Seville

41110

Exelixis Clinical Site #97, Larissa

41404

Exelixis Clinical Site #94, Daegu

42601

Exelixis Clinical Site #21, Daegu

43018

Exelixis Clinical Site #71, Lutsk

43126

Exelixis Clinical #267, Parma

44195

Exelixis Site #159, Cleveland

44500

Exelixis Clinical Site #212, Guadalajara

44600

Exelixis Clinical Site #173, Guadalajara

45040

Exelixis Clinical Site #219, Zapopan

47014

Exelixis Site #168, Meldola

47179

Exelixis Clinical Site #180, Duisburg

47392

Exelixis Clinical Site #58, Busan

48149

Exelixis Clinical Site #179, Münster

48202

Non-participating Site, Detroit

49005

Exelixis Clinical Site #102, Dnipro

49102

Exelixis Clinical Site #186, Dnipro

49241

Exelixis Clinical Site #24, Busan

50134

Exelixis Clinical Site #121, Florence

51100

Exelixis Clinical Site #214, Reims

54007

Exelixis Clinical Site #64, Thessaloniki

54511

Exelixis Clinical Site #230, Vandœuvre-lès-Nancy

55905

Exelixis Clinical Site #203, Rochester

56126

Exelixis Clinical #269, Pisa

58128

Exelixis Clinical Site #34, Hwasun

60126

Exelixis Clinical Site #217, Ancona

61469

Exelixis Clinical Site #40, Gwangju

63011

Exelixis Clinical Site #77, Clermont-Ferrand

64710

Exelixis Clinical Site #257, Monterrey

66205

Exelixis Clinical Site #215, Westwood

67000

Exelixis Clinical Site #213, Strasbourg

67200

Exelixis Clinical Site #36, Strasbourg

68130

Exelixis Clinical Site #19, Omaha

71110

Exelixis Clinical Site #45, Heraklion

72076

Exelixis Clinical Site #136, Tübingen

72530

Exelixis Clinical Site #272, Puebla City

72622

Exelixis Clinical Site #176, Nürtingen

73104

Exelixis Clinical Site #221, Oklahoma City

75015

Exelixis Clinical Site #38, Paris

76070

Exelixis Clinical Site #172, Querétaro City

76230

Exelixis Clinical Site #182, Querétaro City

76504

Exelixis Clinical Site #41, Temple

77027

Exelixis Clinical Site #5, Houston

77030

Exelixis Clinical Site #177, Houston

Exelixis Clinical Site #259, Houston

78200

Exelixis Clinical Site #250, San Luis Potosí City

78209

Exelixis Clinical Site #184, San Luis Potosí City

80045

Exelixis Clinical Site #91, Aurora

80211

Exelixis Clinical Site #14, Denver

81362

Exelixis Clinical #266, Kaohsiung City

83400

Exelixis Clinical Site #74, Hyères

84112

Exelixis Clinical Site #67, Salt Lake City

85741

Exelixis Clinical Site #4, Tucson

85925

Exelixis Clinical Site #222, La Roche-sur-Yon

89169

Exelixis Clinical Site #144, Las Vegas

90404

Exelixis Clinical Site #125, Santa Monica

91010

Exelixis Clinical Site #42, Duarte

92161

Exelixis Clinical Site #114, San Diego

92835

Exelixis Clinical Site #2, Fullerton

94305

Exelixis Clinical Site #245, Stanford

115478

Exelixis Site #166, Moscow

169610

Exelixis Clinical Site #50, Singapore

197022

Exelixis Clinical Site #137, Saint Petersburg

197758

Exelixis Clinical Site #195, Saint Petersburg

258499

Exelixis Clinical Site #87, Singapore

329563

Exelixis Clinical Site #181, Singapore

1311001

Exelixis Clinical Site #30, Safed

2520598

Exelixis Clinical Site #247, Viña del Mar

2540333

Exelixis Clinical Site #119, Valparaíso

3109601

Exelixis Clinical Site #55, Haifa

4810469

Exelixis Clinical Site #113, Temuco

4941492

Exelixis Clinical Site #150, Petah Tikva

5265601

Exelixis Clinical Site #117, Ramat Gan

6423906

Exelixis Clinical Site #35, Tel Aviv

7500653

Exelixis Clinical Site #90, Santiago

7500713

Exelixis Clinical Site #142, Providencia

7500787

Exelixis Clinical #263, Santiago

7500921

Exelixis Clinical Site #139, Santiago

8420383

Exelixis Clinical Site #148, Recoleta

9112001

Exelixis Clinical Site #27, Jerusalem

92093-0698

Exelixis Clinical Site #224, La Jolla

06520

Yale University School of Medicine, New Haven

Yale University, School of Medicine, New Haven

08816

Exelixis Clinical Site #123, East Brunswick

08648

Non-participating Site, Lawrenceville

C1280AEB

Exelixis Clinical Site #122, Ciudad Autonoma de Buenos Aire

B7600FZO

Exelixis Clinical Site #120, Mar del Plata

B2700CPM

Exelixis Site #170, Pergamino

X5004FHP

Exelixis Clinical Site #210, Córdoba

R8500ACE

Exelixis Clinical Site #152, Viedma

S2000CVB

Exelixis Clinical Site #183, Rosario

S2000KZE

Exelixis Clinical #261, Rosario

C1426ANZ

Exelixis Clinical Site #200, Buenos Aires

C1120AAT

Exelixis Clinical Site #256, Caba

C1012AAR

Exelixis Clinical Site #44, Ciudad Autonoma de Buenos Aire

F5300

Exelixis Clinical Site #105, La Rioja

Y4600EHA

Exelixis Clinical Site #101, San Salvador de Jujuy

80510-130

Exelixis Site #163, Curitiba

80520-174

Exelixis Clinical Site #204, Curitiba

22793-080

Exelixis Clinical Site #171, Rio de Janeiro

90610-00

Exelixis Site #157, Porto Alegre

89010-340

Exelixis Clinical Site #132, Blumenau

13083-970

Exelixis Clinical Site #191, Campinas

14048-900

Exelixis Clinical Site #128, Ribeirão Preto

15090-000

Exelixis Clinical Site #106, São José do Rio Preto

04538-132

Exelixis Site #161, São Paulo

14784-400

Exelixis Clinical Site #154, Barretos

60336-232

Exelixis Clinical Site #140, Fortaleza

90110-270

Exelixis Clinical Site #153, Porto Alegre

14015-130

Exelixis Clinical Site #145, Ribeirão Preto

96810-110

Exelixis Clinical Site #116, Santa Cruz do Sul

T6G 1Z2

Exelixis Clinical Site #69, Edmonton

V1Y 5L3

Exelixis Clinical Site #112, Kelowna

E1C 6Z8

Exelixis Clinical Site #147, Moncton

L8V 5C2

Exelixis Clinical Site #83, Hamilton

N6A 5W9

Exelixis Clinical Site #127, London

L6H 3PI

Exelixis Clinical Site #7, Oakville

J2GIT7

Exelixis Clinical Site #178, Granby

H2X 3E4

Exelixis Site #160, Montreal

120 00

Exelixis Clinical Site #63, Prague

656 91

Exelixis Clinical Site #129, Brno

779 00

Exelixis Clinical Site #130, Olomouc

128 00

Exelixis Clinical Site #80, Prague

140 59

Exelixis Clinical Site #31, Prague

180 81

Exelixis Clinical Site #47, Prague

0112

Exelixis Clinical Site #16, Tbilisi

0141

Exelixis Clinical Site #9, Tbilisi

0144

Exelixis Clinical Site #10, Tbilisi

0159

Exelixis Clinical Site #11, Tbilisi

0167

Exelixis Clinical Site #15, Tbilisi

0186

Exelixis Clinical Site #8, Tbilisi

06132

Exelixis Clinical Site #107, Perugia

00144

Exelixis Clinical Site #62, Roma

00168

Exelixis Clinical Site #234, Roma

05100

Exelixis Clinical Site #96, Terni

471-8513

Exelixis Clinical Site #232, Toyota-shi

010-8543

Exelixis Clinical Site #100, Akita

036-8563

Exelixis Clinical Site #104, Hirosaki

277-8577

Exelixis Clinical Site #43, Kashiwa-shi

285-8741

Exelixis Clinical Site #54, Sakura-shi

060-8543

Exelixis Clinical Site #72, Sapporo

060-8648

Exelixis Clinical Site #37, Sapporo

650-0017

Exelixis Clinical Site #70, Kobe

650-0047

Exelixis Clinical Site #52, Kobe

761-0793

Exelixis Clinical Site #84, Kita-gun

252-0375

Exelixis Clinical Site #68, Sagamihara

232-0024

Exelixis Clinical Site #22, Yokohama

981-1293

Exelixis Clinical Site #211, Natori-shi

541-8567

Exelixis Clinical Site #88, Chūōku

350-1298

Exelixis Clinical Site #51, Hidaka

420-8527

Exelixis Clinical Site #216, Shizuoka

160-8582

Exelixis Clinical Site #65, Shinjuku-Ku

755-8505

Exelixis Clinical Site #61, Ube

260-8717

Exelixis Clinical Site #78, Chiba

815-8588

Exelixis Clinical Site #209, Fukuoka

381-8551

Exelixis Clinical Site #26, Nagano

589-8511

Exelixis Clinical Site #81, Ōsaka-sayama

135-8550

Exelixis Clinical Site #75, Tokyo

641-8510

Exelixis Clinical Site #32, Wakayama

06760

Exelixis Clinical Site #187, Mexico City

C.P. 80020

Exelixis Clinical Site #208, Culiacán

01120

Exelixis Clinical Site #174, Mexico City

05-400

Exelixis Clinical Site #243, Otwock

85-796

Exelixis Clinical Site #82, Bydgoszcz

93-513

Exelixis Clinical #268, Lodz

60-569

Exelixis Clinical Site #89, Poznan

4710-243

Exelixis Clinical Site #110, Braga

4835-044

Exelixis Clinical Site #188, Guimarães

1400-038

Exelixis Site #164, Lisbon

1500-650

Exelixis Clinical Site #197, Lisbon

2674-514

Exelixis Clinical Site #196, Loures

4099-001

Exelixis Clinical Site #56, Porto

4200-072

Exelixis Clinical Site #223, Porto

5000-508

Exelixis Clinical Site #193, Vila Real

03080

Exelixis Clinical Site #59, Seoul

03722

Exelixis Clinical Site #46, Seoul

06273

Exelixis Clinical Site #25, Seoul

06351

Exelixis Clinical Site #48, Seoul

03203

Exelixis Clinical Site #229, Elche

07120

Exelixis Clinical Site #220, Palma de Mallorca

08243

Exelixis Clinical Site #12, Manresa

08916

Exelixis Clinical Site #274, Badalona

08003

Exelixis Clinical Site #228, Barcelona

08035

Exelixis Clinical Site #23, Barcelona

08036

Exelixis Clinical Site #255, Barcelona

08041

Exelixis Clinical Site #190, Barcelona

02125

Exelixis Clinical Site #76, Kyiv

SE1 9RT

Exelixis Clinical Site #205, London

SM2 5PT

Exelixis Clinical Site #235, Surrey Quays

TA1 5DA

Exelixis Clinical Site #241, Taunton

BB2 3HH

Exelixis Clinical Site #249, Blackburn

HA6 2RN

Exelixis Clinical Site #231, Northwood

SA2 Q8A

Exelixis Clinical Site #194, Swansea

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Roche-Genentech

INDUSTRY

collaborator

Takeda

INDUSTRY

lead

Exelixis

INDUSTRY