Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

RecruitingOBSERVATIONAL
Enrollment

160

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
HypertensionMenopause, PrematureMenopauseBlood Pressure
Interventions
DIAGNOSTIC_TEST

Microneurography to measure muscle sympathetic nerve activity (MSNA)

Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves

DIAGNOSTIC_TEST

Baroreflex sensitivity testing

Two arms of the baroreflex that will be tested in this study are sympathetic and cardiovagal. Static baroreflex is tested during baseline resting conditions and dynamic baroreflex is tested during Valsalva maneuvers.

DIAGNOSTIC_TEST

Sympathoexcitatory Maneuvers

Cold Pressor Test (CPT) and Upper extremity fatiguing contraction with post exercise circulatory occlusion (PECO) will be performed

DIAGNOSTIC_TEST

Blood tests

Serum FSH, estrogen, progesterone, and testosterone will be measured

Trial Locations (1)

55455

RECRUITING

University of Minnesota, Minneapolis

All Listed Sponsors
lead

University of Minnesota

OTHER