A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)

PHASE3CompletedINTERVENTIONAL
Enrollment

448

Participants

Timeline

Start Date

June 22, 2020

Primary Completion Date

July 25, 2022

Study Completion Date

August 22, 2023

Conditions
Geographic AtrophyMacular Degeneration
Interventions
DRUG

Avacincaptad Pegol

Avacincaptad Pegol Intravitreal Injection

DRUG

Sham

Sham Administration (includes placement of the blunt opening of an empty, needleless syringe barrel on the conjunctiva in the inferotemporal quadrant of the eyeball to simulate the pressure of an injection)

Trial Locations (205)

1068

Hungarian Military Hospital Center, Budapest

1090

Medical University of Vienna, Vienna

1106

Bajcsy Zsilinszky Kórház - Szemészet, Budapest

1133

Budapest Retina Associates, Budapest

1140

Hanush Hospital, Vienna

2000

Sydney Eye Hospital, Sydney

Sydney Retina Clinic and Day Surgery, Sydney

3002

Royal Victorian Eye & Ear Hospital, East Melbourne

4400

Szabolcs-Szatmar-Bereg County Hospital and University Teaching Hospital, Nyíregyháza

6020

Medizinische Universitaet Innsbruck - Universitaetsklinik fuer Augenheilkunde und Optometrie, Innsbruck

8036

Medizinische Universitaet Graz - Augenklinik, Graz

10022

Vitreous Retina Macula Consultants of New York (VRMNY), New York

11021

Long Island Vitreoretinal Consultant, Great Neck

11412

Dr Kai Noor Silmakabinet, Tallinn

11572

OCLI, Oceanside

12180

Ophthalmic Consultants of the Capital Region, Troy

13008

Centre Paradis Monticelli, Marseille

13088

Retina Vitreous Surgeons of Central New York, PC, Liverpool

14620

Retina Associates of Western NY, PC, Rochester

15122

Associates in Ophthalmology, Ltd, West Mifflin

15706

Instituto Oftalmologico Gomez-Ulla, Santiago de Compostela

19104

Scheie Eye Institute, University of Pennsylvania, Philadelphia

19107

Mid Atlantic Retina, Philadelphia

20122

Ospedale Maggiore Policlinico Milano, Milan

20132

IRCCS Ospedale San Raffaele, Milan

20157

Ospedale Luigi Sacco, Milan

20251

Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde Studienzentrum, Hamburg

20815

The Retina Group of Washington, Chevy Chase

21079

CHU Bocage, Dijon

21209

The Retina Care Center, Baltimore

21740

Cumberland Valley Retina Consultants, Hagerstown

23235

Retina Institute of Virginia, Richmond

23502

Wagner Macular & Retina Center, Norfolk

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

24018

Vistar Eye Center, Roanoke

28222

H.U. Puerta de Hierro-Majadahonda, Majadahonda

28803

Western Carolina Retinal Associates, Asheville

29169

Palmetto Retina Center, West Columbia

29456

Charleston Neuroscience Institute, Ladson

29464

Carolina Macula and Retina, Mt. Pleasant

29902

Retina Research of Beaufort, LLC, Beaufort

30060

Georgia Retina, P.C., Marietta

30330

Centro de Ensino e Pesquisa do Instituto da Visao (CEPIV), Belo Horizonte

30625

University Eye Hospital, MHH, Hanover

30909

Southeast Retina Center, Augusta

31000

Clinical hospital Center Osijek, Osijek

31008

Clinica Universidad de Navarra, Pamplona

32308

Southern Vitreoretinal Associates, PL, Tallahassee

32503

Retina Specialty Institute, Pensacola

32607

VitreoRetinal Associates, P.A., Gainesville

32701

Florida Eye Clinic, Altamonte Springs

32901

Florida Eye Associates, Melbourne

33000

CHU de Bordeaux - Hopital Pellegrin, Bordeaux

33064

Rand Eye Institute, Deerfield Beach

33100

Azienda Sanitaria Universitaria Integrata, Udine

33136

University of Miami-Bascom Palmer Eye Institute, Miami

33308

Retina Group of Florida, Fort Lauderdale

33410

Retina Care Specialists, Palm Beach Gardens

33711

Retina Vitreous Associates of Florida, St. Petersburg

33880

Center for Retina and Macula Disease, Winter Haven

33907

Retina Health Center, Fort Myers

33912

National Ophthalmic Research Institute, Fort Myers

34233

Retina Associates of Sarasota, Sarasota

34994

East Florida Eye Institute, Stuart

35128

Azienda Ospedaliera di Padova Unità Operativa Complessa di Clinica Oculistica, Padua

37075

University of Göttingen, Göttingen

37540

Centre St Exupery, Saint-Cyr-sur-Loire

37604

Southeastern Retina Associates, PC, Johnson City

37922

Southeastern Retina Associates, PC, Knoxville

40138

A.O.U. Policlinico Sant'Orsola-Malpighi, Bologna

44043

CHU de Nantes, Nantes

44124

Nuovo Arcispedale Sant' Anna (A.O.U. di Ferrara), Ferrara

45242

Cincinnati Eye Institute, Cincinnati

46100

IMED Servicio Oftalmología, Valencia

46290

Midwest Eye Institute, Indianapolis

47012

Rio Hortega University Hospital, Valladolid

48010

Instituto Clinico Quirurgico de Oftalmologia, Bilbao

48073

Associated Retinal Consultants, P.C., Royal Oak

48145

Augenzentrum am St. Franziskus-Hospital, Münster

48149

Universitätsklinikum Münster, Münster

49100

Department of Ophthalmology, Rabin Medical Center, Petah Tikva

50009

"Hospital Clínico Universitario Lozano Blesa", Zaragoza

50134

Azienda Ospedaliera Universitaria Careggi, Florence

50266

Wolfe Eye Clinic, West Des Moines

50406

Tartu University Hospital, Tartu

50937

Augenklinik University Hospital Cologne, Cologne

52074

RWTH Aachen University, Aachen

55131

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz

55404

Retina Center, Minneapolis

56126

University of Pisa, Pisa

57701

Black Hills Regional Eye Institute, Rapid City

60126

Ospedali Riuniti di Ancona, Ancona

60439

University Retina and Macula Associates, PC, Lemont

61615

Illinois Eye Center, Peoria

63110

St. Louis University, St Louis

66100

"Ospedale Clinicizzato Universita di Chieti Ss Annunziata", Chieti

66215

Retina Associates, LLC, Lenexa

67214

Vitreo Retinal Consultants & Surgeons, Wichita

69002

Centre d'ophtalmologie Rabelais, Lyon

69004

Hopital de la Croix Rousse, Lyon

69130

Centre Pole Vision Val d'Ouest, Écully

70121

Ochsner Medical Center, New Orleans

70300

Shamir Medical Center, Be’er Ya‘aqov

72076

Universitäts-Augenklinik, Tübingen

75006

Centre d'exploration ophtalmologique de l'Odeon, Paris

75010

Hôpital Lariboisière, Paris

75015

Centre Ophtalmologique d'Imagerie et de Laser, Paris

75019

Fondation Alolphe de Rotschild, Paris

75231

Retina Foundation of the Southwest, Dallas

76087

Strategic Clinical Research Group, Willow Park

76092

Retina Center of Texas, Southlake

76100

Kaplan Medical Center, Rehovot

77025

Retina and Vitreous of Texas, PLLC, Houston

77384

Retinal Consultants of Houston, The Woodlands

78240

Medical Center Ophthalmology Associates, San Antonio

78503

Valley Retina Institute, McAllen

78705

Austin Retina Associates, Austin

79106

Southwest Retina Specialists, Amarillo

79606

Retina Research Institute of Texas, Abilene

80045

University of Colorado, Aurora

80131

AOU Universita degli Studi della Campania Luigi Vanvitelli UOC Oculistica, Naples

80228

Colorado Retina Associates, Lakewood

80336

Ludwig-Maximilians-University Munich, Munich

80909

Retina Consultants of Southern Colorado, P.C., Colorado Springs

81675

Clinic Rechts der Isar, Munich

84107

Retinal Associates of Utah, Salt Lake City

Rocky Mountain Retina Consultants, Salt Lake City

84132

University of Utah, John A. Moran Eye Center, Salt Lake City

89052

Retina Consultants of Nevada, Henderson

89502

Sierra Eye Associates, Reno

90095

Jules Stein Eye Institute/David Geffen School of Medicine, Los Angeles

90211

Retina-Vitreous Associates Medical Group, Beverly Hills

91105

Doheny Eye Center, UCLA, Pasadena

91120

Hadassah University Hospital, Jerusalem

92093

University of California, San Diego, La Jolla

92211

Southern California Desert Retina Consultants, Palm Desert

92374

Retina Consultants of Southern California, Redlands

92705

Orange County Retinal Medical Group, Santa Ana

92835

Retina Consultants of Orange County, Fullerton

93036

California Retina Consultants, Oxnard

93720

Eye Medical Center of Fresno, Fresno

94010

Hopital Intercommunal, Créteil

94040

Northern California Retina Vitreous Associates, Mountain View

95008

Retinal Diagnostic Center, Campbell

95825

Retinal Consultants Medical Group, Inc., Sacramento

96701

Retina Consultants of Hawaii, Inc, ‘Aiea

97221

Retina Northwest, PC, Portland

97225

EyeHealth Northwest, Portland

97239

Casey Eye Institute, Portland

97520

Retina and Vitreous Center of Southern Oregon, Ashland

98004

Pacific Northwest Retina, Bellevue

98383

Retina Center NW, PLLC, Silverdale

110311

Fundacion OJlalmologica Nacional - FUNDONAL, Bogotá

3109601

Rambam Medical Centre, Haifa

3436212

Carmel Medical Center, Haifa

5822012

Edith Wolfson Medical Center, Holon

6423906

Sourasky Medical Center, Tel Aviv

7830604

Barzilai Medical Center, Ashkelon

06810

Connecticut Eye Consultants, P.C., Danbury

06385

Retina Group of New England, PC, Waterford

02114

Ophthalmic Consultants of Boston, Boston

01107

Retina Research Institute at New England Retinal Consultants, Springfield

01605

UMASS Memorial Eye Center, Worcester

Vitreoretinal Associates, PC, Worcester

07003

Retina Center of New Jersey, LLC, Bloomfield

C1116ABA

Centro Oftalmológico Dr. Charles SA, Buenos Aires

Cl061AAE

Buenos Aires Macula S.A., Buenos Aires

CP2000

Centro Médico Grupo Laser Visión, Rosario

S2000ANJ

"Centro de Diagnóstico y Cirugía Ocular Oftalmólogos Especialistas", Rosario

C1120AAN

Instituto Oftalmológico de Buenos Aires, Buenos Aires

X5000AAJ

Centro Privado de Ojos Romagosa S.A., Córdoba

X5000III

Instituto Oftalmológico de Córdoba, Córdoba

M5500GGK

Centro Privado de Oftalmologia - OFTAR Mendoza SRL, Mendoza

S2000TC

Centro Medico Micro Diagnostico y Microcirugla Ocular, Rosario

Unknown

CHU Brugmann, Brussels

University of Bonn, Bonn

04038-032

IPEPO - Instituto da visão, São Paulo

04023-062

Hospital Sao Paulo - UNIFESP, Vila Clementino

T2H 0C8

Calgary Retina Consultants, Calgary

V5Z3N9

UBC/VGH Eye Care Center, Vancouver

N6A4V2

St.Joseph's Health Care London, London

L4W 1W9

Canadian Centre for Advanced Eye Therapeutics Inc., Mississauga

K1H8L6

University of Ottawa Eye Institute, Ottawa

M5T 2S8

University Health Network, Toronto

K2B 7E9

Retina Centre of Ottawa, Ottawa

050016

Clinica De Oftalmologia Sandiego, Medellín

150 00

Axon Clinical s.r.o., Prague

04103

University clinic Leipzig AÖR, Leipzig

H-1085

Semmelweis University, Dept of Ophthalmology, Budapest

H-4032

Debrecen University Clinical Center, Dept of Ophthalmology, Debrecen

H-7621

Ganglion Medical Center, Pécs

H-6720

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged

00133

Fondazione PTV, Roma

00198

Fondazione GB Bietti IRCCS, Roma

LV-1002

Pauls Stradinis Clinical University Hospital, Riga

85-631

Klinika Okulistyczna OFT ALMIKA Sp. z o. o., Bydgoszcz

91-485

Medical Center Julianów, Lodz

42-600

Caminomed, Tarnowskie Góry

50-556

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego, Wroclaw

08021

Clinica de Oftalmologia Barraquer, Barcelona

08022

Institut Catala de Retina, Barcelona

Institut de la Macula, Barcelona

08195

VOR - Hospital General de Catalunya, Barcelona

CP 14012

Hospital La Arruzafa, Córdoba

HU3 2JZ

Hull University Teaching Hospitals NHS Trust, Hull

All Listed Sponsors
lead

IVERIC bio, Inc.

INDUSTRY

NCT04435366 - A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor) | Biotech Hunter | Biotech Hunter