408
Participants
Start Date
August 6, 2020
Primary Completion Date
May 31, 2024
Study Completion Date
October 15, 2025
Lenvatinib
20 mg once daily, taken as oral capsules
Pembrolizumab
200 mg 30-minute IV infusion on day 1 of each 21-day cycle
Docetaxel
75 mg/m\^2 administered as an IV infusion on day 1 of each 21-day cycle
Capecitabine
1250 mg/m\^2 twice daily on days 1-14 of each 21-day cycle, taken as oral tablets
Paclitaxel
80 mg/m\^2 administered as an IV infusion on days 1, 8, and 15 of each 21-day cycle
Cetuximab
400 mg/m\^2 loading dose, followed by 250 mg/m\^2 administered as an IV infusion on days 1, 8, and 15 of each 21-day cycle
Lenvatinib
24 mg once daily, taken as oral capsules
Chang Gung Memorial Hospital - Linkou Branch ( Site 1203), Taoyuan District
Taichung Veterans General Hospital ( Site 1206), Taichung
National Cheng Kung University Hospital ( Site 1202), Tainan City
Rigshospitalet University Hospital Copenhagen ( Site 1000), Copenhagen
Blacktown Hospital ( Site 0101), Sydney
Mid North Coast Cancer Institute ( Site 0109), Port Macquarie
Monash Health ( Site 0102), Clayton
Gallipoli Medical Research Ltd-GMRF CTU ( Site 0105), Greenslopes
The Townsville Hospital ( Site 0107), Douglas
Royal Adelaide Hospital ( Site 0110), Adelaide
Laura and Isaac Perlmutter Cancer Center ( Site 1582), New York
National Taiwan University Hospital ( Site 1200), Taipei
Taipei Veterans General Hospital ( Site 1201), Taipei
Perlmutter Cancer Center at Winthrop Oncology Hematology Associates NYU Langone Health ( Site 1597), Mineola
Hopital La Timone ( Site 0503), Marseille
Seoul National University Bundang Hospital ( Site 1801), Seongnam
Centro Oncologico de Galicia ( Site 0706), A Coruña
Ajou University Hospital ( Site 1802), Suwon
Penn State Hershey Medical Center ( Site 1561), Hershey
Gettysburg Cancer Center ( Site 1594), Gettysburg
Fox Chase Cancer Center ( Site 1502), Philadelphia
Georgetown University Medical Center ( Site 1520), Washington D.C.
University of Maryland Greenebaum Cancer Center ( Site 1522), Baltimore
Hematology Oncology Associates of Fredericksburg ( Site 1537), Fredericksburg
Duke Cancer Institute ( Site 1541), Durham
Hospital Ramon y Cajal ( Site 0705), Madrid
Levine Cancer Institute ( Site 1590), Charlotte
Hospital Virgen de la Victoria ( Site 0702), Málaga
Medical University of South Carolina ( Site 1579), Charleston
St Francis Cancer Center-Research Office ( Site 1607), Greenville
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1521), Marietta
Georgia Cancer Center at Augusta University ( Site 1575), Augusta
Memorial Health University Medical Center ( Site 1626), Savannah
UF Health ( Site 1554), Gainesville
Mid Florida Hematology and Oncology Center ( Site 1606), Orange City
Cleveland Clinic Florida ( Site 1596), Weston
Centre de Cancerologie du Grand Montpellier ( Site 0508), Montpellier
Jackson Oncology Associates, PLLC-Clinical Trials ( Site 1625), Jackson
Hattiesburg Clinic ( Site 1515), Hattiesburg
Norton Hospital-Norton Cancer Institute - Downtown ( Site 1601), Louisville
Mercy Health-Paducah Cancer Center ( Site 1623), Paducah
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 1558), Columbus
University Hospital Cleveland ( Site 1578), Cleveland
Cleveland Clinic Main ( Site 1598), Cleveland
University of Cincinnati Medical Center ( Site 1567), Cincinnati
Hospital General de Valencia ( Site 0703), Valencia
IU Health Ball Memorial Hospital, Inc.-IU Health Ball Memorial Cancer Center ( Site 1612), Muncie
VA Ann Arbor Healthcare System ( Site 1584), Ann Arbor
Barbara Ann Karmanos Cancer Institute ( Site 1566), Detroit
Henry Ford Health System ( Site 1544), Detroit
Instituto de Cancerología ( Site 0408), Medellín
University of Iowa ( Site 1572), Iowa City
Medical College of Wisconsin Clinical Cancer Center ( Site 1574), Milwaukee
St. Vincent Frontier Cancer Center ( Site 1507), Billings
NorthShore University HealthSystem - Evanston Hospital ( Site 1614), Evanston
Rush University Medical Center ( Site 1560), Chicago
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 0510), Clermont-Ferrand
Washington University School of Medicine ( Site 1500), St Louis
University of Kansas Cancer Center ( Site 1538), Westwood
University Of Nebraska Medical Center ( Site 1570), Omaha
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 1627), Omaha
Our Lady of the Lake RMC-Clinical Research ( Site 1624), Baton Rouge
Mary Bird Perkins Cancer Center Baton Rouge ( Site 1622), Baton Rouge
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 1508), Tulsa
Institut Curie ( Site 0500), Paris
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen ( Site 0509), Rouen
The Center For Cancer And Blood Disorders ( Site 1569), Fort Worth
Chang Gung Medical Foundation - Kaohsiung ( Site 1204), Kaohsiung City
Beacon Cancer Care ( Site 1599), Post Falls
Utah Cancer Specialists ( Site 1621), Salt Lake City
Huntsman Cancer Institute ( Site 1532), Salt Lake City
UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1568), Los Angeles
City of Hope ( Site 1519), Duarte
Institut Gustave Roussy ( Site 0505), Villejuif
MultiCare Health System-MultiCare Oncology - Puget Sound ( Site 1609), Tacoma
Administradora Country S.A.S - Clínica del Country ( Site 0407), Bogotá
Sociedad De Oncologia Y Hematologia Del Cesar ( Site 0404), Valledupar
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1704), Craiova
IMAT S.A.S ( Site 0409), Montería
Cabinet Medical Oncomed ( Site 1707), Timișoara
Cardiomed SRL Cluj-Napoca ( Site 1701), Cluj-Napoca
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1702), Cluj-Napoca
China Medical University Hospital ( Site 1205), Taichung
S.C. Radiotherapy Center Cluj S.R.L ( Site 1706), Floreşti
Rambam Health Care Campus-Oncology Division ( Site 0602), Haifa
Chaim Sheba Medical Center ( Site 0600), Ramat Gan
Soroka Medical Center-Oncology ( Site 0604), Beersheba
Hadassah Medical Center. Ein Kerem ( Site 0601), Jerusalem
Yale-New Haven Hospital-Yale Cancer Center ( Site 1505), New Haven
Boston Medical Center ( Site 1605), Boston
University of Massachusetts Chan Medical School ( Site 1616), Worcester
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1555), Hackensack
Rutgers Cancer Institute of New Jersey ( Site 1523), New Brunswick
Inova Schar Cancer Institute ( Site 1550), Fairfax
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0806), Porto Alegre
A. C. Camargo Cancer Center ( Site 0809), São Paulo
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0304), Calgary
BC Cancer-Vancouver Center ( Site 0306), Vancouver
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0307), Hamilton
Sunnybrook Research Institute ( Site 0308), Toronto
Oslo universitetssykehus, Radiumhospitalet ( Site 1102), Oslo
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 1401), Vila Nova de Gaia
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 1400), Porto
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 1703), Bucharest
Spitalul Clinic Colțea ( Site 1708), Bucharest
Severance Hospital Yonsei University Health System ( Site 1800), Seoul
Samsung Medical Center ( Site 1803), Seoul
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0700), L'Hospitalet de Llobregat
HOSPITAL CLÍNIC DE BARCELONA ( Site 0707), Barcelona
Hospital Universitari Vall d Hebron ( Site 0701), Barcelona
Aberdeen Royal Infirmary ( Site 0911), Aberdeen
Castle Hill Hospital ( Site 0910), Cottingham
The Beatson West of Scotland Cancer Centre ( Site 0909), Glasgow
Guy s and St Thomas Hospital NHS Foundation Trust ( Site 0903), London
University Hospital Southampton NHS Foundation Trust ( Site 0905), Southampton
Royal Marsden Hospital ( Site 0902), London
Charing Cross Hospital ( Site 0908), London
Musgrove Park Hospital ( Site 0904), Taunton
Royal Marsden Hospital. ( Site 0901), Sutton
The Christie NHS Foundation Trust ( Site 0907), Manchester
Eisai Inc.
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY