Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye

PHASE3CompletedINTERVENTIONAL
Enrollment

1,011

Participants

Timeline

Start Date

August 11, 2020

Primary Completion Date

July 27, 2022

Study Completion Date

August 7, 2024

Conditions
Neovascular Age-Related Macular Degeneration
Interventions
DRUG

Aflibercept High Dose VEGF Trap-Eye (BAY86-5321)

Solution in Vial, intravitreal (IVT) injection

DRUG

Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321)

Solution in Vial, 2 mg, intravitreal (IVT) injection

Trial Locations (235)

0

The Affiliated Eye Hospital of Wenzhou Medical College, Wenzhou

105

"LTD Innova", Tbilisi

111

Shin Kong Wu Ho-Su Memorial Hospital, Taipei

114

"LTD Chichua Medical Center MZERA", Tbilisi

198

Fondazione G.B.Bietti Per Lo Studio E La Ricerca In Oftalmologia, Rome

1002

Department of Ophthalmology, Riga

1006

RétinElysée, Lausanne

1024

Centralna Polyclinica MVS Ukraiiny, Kyiv

1133

Budapest Retina Associates, Budapest

1140

Hanusch-Krankenhaus Wien, Vienna

1309

SEHAT Pentagram, Sofia

1408

Spec. Hosp. for Active Treatment for Eye Diseases Zrenie, Sofia

1431

University Multiprofile Hospital For Active Treatment 'Alexandrovska' EAD, Sofia

1784

Specialized Hospital For Active Treatment of Eye Diseases Zora, Sofia

2000

Sydney Retina Clinic, Sydney

2145

Westmead Hospital, Westmead

2150

Marsden Eye Surgery Center, Parramatta

2640

Eyeclinic Albury Wodonga, Albury

4020

Kepler Universitätsklinikum Campus III, Linz

4021

Konventhospital Barmherzige Brüder Linz, Linz

4600

"LTD Clinic LJ - Opthalmology", Kutaisi

6129

A.O. di Perugia, Perugia

6720

Szent-Gyorgyi Albert Orvostudomanyi Egyetem, Szeged

7000

Hobart Eye Surgeons, Hobart

8036

Medizinische Universität Graz, Graz

Hospital Clínic i Provincial de Barcelona, Barcelona

8063

Stadtspital Triemli, Zurich

9000

Sveta Petka Eye Hospital, Varna

9020

Klinikum Klagenfurt am Wörthersee, Klagenfurt

9042

Azienda Ospedaliero-Universitaria Di Cagliari, Cagliari

10034

Fakultni nemocnice Kralovske Vinohrady, Prague

10138

AS Ida-Tallinna Keskhaigla - Oftalmoloogiakeskus, Tallinn

11000

Clinical Center of Serbia, Belgrade

Clinical hospital center Zvezdara, Belgrade

11021

Long Island Vitreoretinal Consultants - Great Neck, Great Neck

11217

Taipei Veterans General Hospital, Taipei

11563

Ophthalmic Consultants of Long Island, Lynbrook

11788

Vitreoretinal Consultants of NY - Hauppauge, Hauppauge

12180

Ophthalmic Consultants of the Capital Region - Troy, Troy

13008

Centre d'Ophtalmologie - Paradis-Monticelli, Marseille

13620

Seoul National University Bundang Hospital, Seongnam-si

14004

Hospital Universitario Reina Sofia - Oftalmologia, Córdoba

15706

Instituto Oftalmologico Gomez-Ulla S.L. - Oftalmologia, Santiago de Compostela

16507

Erie Retinal Research, Erie

18017

Mid Atlantic Retina - Philadelphia / Wills Eye Hospital, Bethlehem

18704

Eye Care Specialists - Kingston, PA, Kingston

20122

ASST Fatebenefratelli Sacco, Milan

20132

Ospedale San Raffaele s.r.l. - Oculistica, Milan

21000

Klinicki centar Vojvodine, Novi Sad

21209

The Retina Care Center - Baltimore, Baltimore

25006

"Private Enterprise Private Production Company Acinus, Treatment and Diagnostic Center", Kropyvnytskyi

26505

West Virginia University, Morgantown

27157

Wake Forest Baptist Health, Winston-Salem

29169

Palmetto Retina Center - West Columbia, West Columbia

29414

Charleston Neuroscience Institute - Charleston, Charleston

32204

Florida Retina Institute- Jacksonville Oak, Jacksonville

32308

Southern Vitreoretinal Associates, P.L. - Tallahassee, Tallahassee

32503

Retina Specialty Institute - Pensacola, Pensacola

32806

Florida Retina Institute - Orlando, Orlando

32901

Florida Eye Associates - Melbourne Main Office, Melbourne

33064

Rand Eye Institute, Deerfield Beach

33126

Retina Macula Specialists Of Miami - LeJeune Road Office, Miami

33305

Chang Gung Memorial Hospital at Linkou, Taoyuan District

33308

Retina Group of Florida - Fort Lauderdale, Fort Lauderdale

33711

Retina Vitreous Associates of Florida - Saint Petersburg, St. Petersburg

36011

Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi, Poltava

37540

Centre ophtalmologique Saint-Exupéry, Saint-Cyr-sur-Loire

38119

Charles Retina Specialists - Germantown, Memphis

43016

Midwest Retina - Main Office, Dublin

46014

Hospital General Universitario de Valencia, Valencia

46026

Hospital Universitario Y Politecnico La Fe - Oftalmologia, Valencia

49241

Pusan National University Hospital, Busan

50000

Shijiazhuang General Hospital, Shijiazhuang

50009

Hospital Universitario Miguel Servet - Oftalmologia, Zaragoza

50406

Sihtasutus Tartu Ülikooli Kliinikum - Silmakliinik, Tartu

53792

University of Wisconsin - Madison, Madison

55435

Vitreo Retinal Surgery PA - Edina, Edina

57701

Black Hills Regional Eye Institute, Rapid City

60126

Retina Associates IL, Elmhurst

60452

University Retina and Macula Associates, Oak Forest

75475

AP-HP - Hopital Lariboisiere, Paris

76104

Texas Retina Associates - Fort Worth, Fort Worth

77384

Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center, The Woodlands

Retina Consultants of Texas - The Woodlands, The Woodlands

78240

Medical Center Ophthalmology Associates - Northwest, San Antonio

Retina Consultants of Texas - San Antonio Medical Center, San Antonio

78705

Austin Retina Associates - Central, Austin

80909

Retina Consultants of Southern Colorado, PC, Colorado Springs

87109

Eye Associates of New Mexico - Albuquerque - Retina Center, Albuquerque

89144

Retina Consultants of Nevada - Summerlin, Las Vegas

91107

Azul Vision Pasadena, Pasadena

92037

Perlman Medical Offices at UC San Diego Health - Endocrinology, San Diego

92064

Retina Consultants San Diego - Poway, Poway

92374

Retina Consultants of Southern California, Redlands

92505

Kaiser Permanente Riverside Medical Center - Cardiology, Riverside

92835

Retina Consultants of Orange County - Fullerton, Fullerton

94040

Northern California Retina Vitreous Associates - Mountain View Office, Mountain View

96701

Retina Consultants of Hawaii - Pali Momi Medical Center, ‘Aiea

97210

Retina Northwest - NW Lovejoy, Portland

97302

Retina Consultants, LLC, Salem

99204

Spokane Eye Clinical Research, Spokane

100000

Beijing Aier Intech Eye Hospital, Beijing

100005

Beijing Tongren Hospital, Capital Medical University (East), Beijing

100032

Peking University People's Hospital, Beijing

100730

Beijing Hospital, Beijing

110034

Shenyang He Eye Specialist Hospital, Shenyang

119021

Scientific Research Institution of Ophthalmic Diseases, Moscow

119074

National University Hospital Medical Centre, Singapore

127486

FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov, Moscow

130022

Eye Center of the second Bethune Hospital, jinlin University, Changchun

134001

Tonghua Central Hospital, Tonghua

168751

Singapore National Eye Centre, Singapore

200065

Shanghai Tongji Hospital of Tongji University, Shanghai

200080

Shanghai General Hospital, Shanghai

221002

The First People's Hospital of Xuzhou, Xuzhou

230601

The Second Hospital of Anhui medical university, Hefei

300052

Tianjin Medical University General Hospital, Tianjin

300384

Tianjin Eye Hospital, Tianjin

Tianjin Medical University Eye Hospital, Tianjin

310000

The 1st Affiliated Hospital of Zhejiang University, Hangzhou

310014

ZheJiang Provincial People's Hospital, Hangzhou

330006

Jiangxi Provincial People's Hospital, Nanchang

The First Affiliated Hospital of NanChang University, Nanchang

400020

Chongqing Aier Ophthalmology Hospital, Chongqing

430030

Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech., Wuhan

Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech, Wuhan

450008

Henan Provincial Eye Hospital, Henan

634050

Guangzhou Aier Eye Hospital, Guangzhou

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an

750002

People's Hospital of Ningxia Hui Autonomous Region - Opthalmology, Ningxia

830011

The First Affiliated Hospital of Xinjiang Medical University, Ürümqi

3109601

Rambam Health Corporation, Haifa

3436212

Lady Davis Carmel Medical Center, Haifa

4428164

Meir Medical Center, Kfar Saba

5262000

Chaim Sheba Medical Center, Ramat Gan

6789140

Assuta Medical Centers - HaShalom, Tel Aviv

7610001

Kaplan Medical Center, Rehovot

9112001

Hadassah Hebrew University Hospital Ein Kerem, Jerusalem

85021-8865

Arizona Retina & Vitreous Consultants - Central Phoenix Phoenix, Phoenix

06320

New England Retina Associates, New London

32607-2557

Vitreo Retinal Associates PA - The Millennium Center Location, Gainesville

50266-7705

Wolfe Eye Clinic - Des Moines, West Des Moines

02114

Ophthalmic Consultants of Boston - Boston, Boston

07003

Retina Center of New Jersey, Bloomfield

08820

NJ Retina - Edison Office, Edison

37212-1610

Vanderbilt University Medical School, Nashville

05401-1473

The University of Vermont Medical Center (Fletcher Allen Health Care) - Main Campus, Burlington

C1015ABO

Organizacion Medica de Investigacion (OMI), Buenos Aires

C1120AAN

OFTALMOS, Instituto Oftalmologico de Alta Complejidad, Buenos Aires

Unknown

"Multiprofile Hospital for Active Treatment Sveta Sofia , Internal Diseases Department"

Aier Eye Hospital (Chengdu), Chengdu

"Centro Hospitalar Vila Nova de Gaia e Espinho , Unit 1 - Clinical Research Center"

"Hospital de la Santa Creu i Sant Pau , Gynecology Department"

N6A 4V2

St.Joseph's Health Care-London, London

M3C 0G9

Toronto Retina Institute, Toronto

J7H1S6

Institut de l'Oeil des Laurentides, Boisbriand

TBC

The 1st Affiliated Hospital Fujian Medical University, Fuzhou

Berner Augenklinik am Lindenhofspital, Bern

050010

Hebei eye hospital, Hebei

500 05

Fakultní Nemocnice Hradec Kralové, Hradec Králové

708 52

Fakultní nemocnice Ostrava, Ostrava

323 00

Fakultni nemocnice Plzen - Lochotin, Plzen-Lochotin

110 00

Charles University in Prague, Prague

140 00

Lexum a.s., Evropska ocni klinika, Prague

150 00

Axon Clinical, s.r.o., Prague

0186

"JSC Evex Hospitals'", Tbilisi

00133

Azienda Ospedaliera Policlinico Universitario Tor Vergata, Rome

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome

491-8551

Daiyukai Daiichi Hospital, Ichinomiya

480-1195

Aichi Medical University Hospital, Nagakute

466-8560

Nagoya University Hospital, Nagoya

467-8602

Nagoya City University Hospital, Nagoya

802-8555

Kokura Memorial Hospital, Kitakyushu

830-0011

Kurume University Hospital, Kurume

963-8052

Southern Tohoku Eye Clinic, Kōriyama

371-8511

Gunma University Hospital, Maebashi

060-8604

Sapporo City General Hospital, Sapporo

062-0931

KKR Sapporo Medical Center, Sapporo

660-8550

Hyogo Prefectural Amagasaki General Medical Center, Amagasaki

650-0017

Kobe University Hospital, Kobe

310-0845

Kozawa Eye Hospital and Diabetes Center, Mito

920-0293

Kanazawa Medical University Hospital, Kahoku-gun

920-8641

Kanazawa University Hospital, Kanazawa

761-0793

Kagawa University Hospital, Kita-gun

211-0053

Medical corporation Eiwakai Dannoue Ophthalmology clinic, Kawasaki

216-8511

St. Marianna University Hospital, Kawasaki

242-0001

Otakeganka Tsukimino Clinic, Yamato

514-8507

Mie University Hospital, Tsu

390-8621

Shinshu University Hospital, Matsumoto

634-8522

Nara Medical University Hospital, Kashihara

879-5593

Oita University Hospital, Yufu

710-8522

Kurashiki Medical Center, Kurashiki

700-8558

Okayama University Hospital, Okayama

903-0215

University of the Ryukyus Hospital, Nakagami

573-1191

Kansai Medical University Hospital, Hirakata

570-8507

Kansai Medical University Medical Center, Moriguchi

589-8511

Kindai University Hospital, Osakasayama-shi

113-8655

The University of Tokyo Hospital, Bunkyo-ku

104-8560

St.Luke's International Hospital, Chuoku

134-0088

Nishikasai Inouye Eye Hospital, Edogawa-ku

193-0998

Tokyo Medical University Hachioji Medical Center, Hachiōji

174-0071

Tokiwadai Muranaka Eye Clinic, Itabashi-ku

152-8902

National Hospital Organization Tokyo Medical Center, Meguro-ku

160-8582

Keio University Hospital, Shinjuku-ku

162-8666

Tokyo Women's Medical University Hospital, Shinjuku-ku

755-8505

Yamaguchi University Hospital, Ube

409-3898

University of Yamanashi Hospital, Chūō

010-8543

Akita University Hospital, Akita

812-0011

Hayashi Eye Hospital, Fukuoka

960-1295

Fukushima Medical University Hospital, Fukushima

734-8551

Hiroshima University Hospital, Hiroshima

889-1692

University of Miyazaki Hospital, Miyazaki

852-8511

Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki

330-8553

Japanese Red Cross Saitama Hospital, Saitama

770-8503

Tokushima University Hospital, Tokushima

640-9558

Japanese Red Cross Wakayama Medical center, Wakayama

990-9585

Yamagata University Hospital, Yamagata

LV-1009

Latvian American Eye Center, Riga

LV-1038

"Riga East Clinical University Hospital Gailezers", Riga

LT-50161

Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas

LT-92288

PI Klaipedos University Hospital, Klaipėda

LT-08661

Vilnius University Hospital Santaros Klinikos, Vilnius

1050-078

ALM Oftalmolaser - Oftalmologia Medica e Cirurgica, Lisbon

3000-548

AIBILI, Coimbra

Espaco Medico de Coimbra, Coimbra

4099-001

Centro Hospitalar Universitario do Porto, Porto

950 01

Fakultna nemocnica Nitra, Nitra

075 01

Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s., Trebišov

911 71

Fakultna nemocnica Trencin, Trenčín

012 07

Fakultna nemocnica s poliklinikou Zilina, Žilina

135-280

Nune Eye Hospital - Retina Center Ophthalmology, Seoul

05505

Asan Medical Center - Oncology Department, Seoul

612-862

Inje University Haeundae Paik Hospital, Busan

03080

Seoul National University Hospital (b), Seoul

06351

Samsung Medical Center - Oncology Department, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Regeneron Pharmaceuticals

INDUSTRY

lead

Bayer

INDUSTRY