804
Participants
Start Date
October 8, 2020
Primary Completion Date
December 31, 2032
Study Completion Date
December 31, 2032
3-Dimensional Conformal Radiation Therapy
Undergo 3D CRT
Apalutamide
Given PO
Computed Tomography
Undergo PET/CT
Degarelix
Given SC
External Beam Radiation Therapy
Undergo EBRT
Fluciclovine F18
Given IV
Goserelin Acetate
Given SC
Intensity-Modulated Proton Therapy
Undergo IMPT
Intensity-Modulated Radiation Therapy
Undergo IMRT
Leuprolide Acetate
Given IM
Magnetic Resonance Imaging
Undergo PET/MR
Positron Emission Tomography
Undergo PET/CT or PET/MR
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
Relugolix
Given PO
Stereotactic Body Radiation Therapy
Undergo SBRT
Triptorelin
Given IM
Volume Modulated Arc Therapy
Undergo VMAT
RECRUITING
Mount Sinai Union Square, New York
RECRUITING
Mount Sinai Chelsea, New York
RECRUITING
Mount Sinai West, New York
RECRUITING
Lenox Hill Hospital, New York
RECRUITING
Mount Sinai Hospital, New York
RECRUITING
Manhattan Eye Ear and Throat Hospital, New York
RECRUITING
Montefiore Medical Center-Einstein Campus, The Bronx
RECRUITING
Montefiore Medical Center-Weiler Hospital, The Bronx
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
Phelps Memorial Hospital Center, Sleepy Hollow
RECRUITING
Westchester Medical Center, Valhalla
RECRUITING
Northwell Health/Center for Advanced Medicine, Lake Success
RECRUITING
Northwell Health Imbert Cancer Center, Bay Shore
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
UPMC-Heritage Valley Health System Beaver, Beaver
RECRUITING
UPMC Cancer Center-Natrona Heights, Natrona Heights
RECRUITING
UPMC Hillman Cancer Center in Coraopolis, Moon Township
RECRUITING
UPMC Cancer Center - Monroeville, Monroeville
RECRUITING
UPMC-Magee Womens Hospital, Pittsburgh
RECRUITING
UPMC-Saint Margaret, Pittsburgh
RECRUITING
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
RECRUITING
UPMC-Shadyside Hospital, Pittsburgh
RECRUITING
UPMC-Passavant Hospital, Pittsburgh
RECRUITING
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh
RECRUITING
UPMC Washington Hospital Radiation Oncology, Washington
RECRUITING
UPMC Cancer Center-Uniontown, Uniontown
RECRUITING
UPMC Uniontown Hospital Radiation Oncology, Uniontown
RECRUITING
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
RECRUITING
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown
RECRUITING
UPMC Hillman Cancer Center - New Castle, New Castle
RECRUITING
UPMC Cancer Center at UPMC Horizon, Farrell
RECRUITING
UPMC Cancer Center at UPMC Northwest, Seneca
RECRUITING
UPMC Hillman Cancer Center Erie, Erie
RECRUITING
UPMC Altoona, Altoona
RECRUITING
Carlisle Regional Cancer Center, Carlisle
RECRUITING
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg
RECRUITING
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
RECRUITING
UPMC Memorial, York
RECRUITING
UPMC Susquehanna, Williamsport
RECRUITING
Fox Chase Cancer Center Buckingham, Furlong
RECRUITING
Crozer-Keystone Regional Cancer Center at Broomall, Broomall
RECRUITING
Delaware County Memorial Hospital, Drexel Hill
RECRUITING
Penn Presbyterian Medical Center, Philadelphia
RECRUITING
University of Pennsylvania/Abramson Cancer Center, Philadelphia
RECRUITING
Thomas Jefferson University Hospital, Philadelphia
RECRUITING
Fox Chase Cancer Center, Philadelphia
RECRUITING
Temple University Hospital, Philadelphia
RECRUITING
Crozer Regional Cancer Center at Brinton Lake, Glen Mills
RECRUITING
Fox Chase Cancer Center - East Norriton Hospital Outpatient Center, East Norriton
RECRUITING
Sibley Memorial Hospital, Washington D.C.
RECRUITING
Suburban Hospital, Bethesda
ACTIVE_NOT_RECRUITING
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
ACTIVE_NOT_RECRUITING
University of Maryland/Greenebaum Cancer Center, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
Virginia Commonwealth University/Massey Cancer Center, Richmond
RECRUITING
ECU Health Oncology Kenansville, Kenansville
RECRUITING
ECU Health Oncology Kinston, Kinston
RECRUITING
ECU Health Oncology Richlands, Richlands
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Moffitt Cancer Center-International Plaza, Tampa
RECRUITING
Moffitt Cancer Center - McKinley Campus, Tampa
RECRUITING
Moffitt Cancer Center, Tampa
RECRUITING
Baptist Memorial Hospital and Cancer Center-Union County, New Albany
RECRUITING
Baptist Memorial Hospital and Cancer Center-Oxford, Oxford
RECRUITING
Baptist Cancer Center-Grenada, Grenada
ACTIVE_NOT_RECRUITING
University of Mississippi Medical Center, Jackson
SUSPENDED
Jewish Hospital, Louisville
RECRUITING
Saint Joseph Hospital, Lexington
RECRUITING
Saint Joseph Radiation Oncology Resource Center, Lexington
RECRUITING
Saint Joseph Hospital East, Lexington
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
ACTIVE_NOT_RECRUITING
University of Cincinnati Cancer Center-West Chester, West Chester
ACTIVE_NOT_RECRUITING
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
RECRUITING
Good Samaritan Hospital - Cincinnati, Cincinnati
RECRUITING
Bethesda North Hospital, Cincinnati
RECRUITING
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek
RECRUITING
William S Middleton VA Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Cancer Center of Western Wisconsin, New Richmond
RECRUITING
Aspirus Regional Cancer Center, Wausau
RECRUITING
Langlade Hospital and Cancer Center, Antigo
RECRUITING
Marshfield Medical Center-Marshfield, Marshfield
RECRUITING
Marshfield Medical Center - Weston, Weston
RECRUITING
Ascension Saint Michael's Hospital, Stevens Point
RECRUITING
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
RECRUITING
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids
RECRUITING
Ascension Saint Mary's Hospital, Rhinelander
RECRUITING
Marshfield Clinic-Minocqua Center, Minocqua
RECRUITING
Marshfield Medical Center-EC Cancer Center, Eau Claire
RECRUITING
Marshfield Medical Center-Rice Lake, Rice Lake
RECRUITING
Lakeview Hospital, Stillwater
RECRUITING
Regions Hospital, Saint Paul
RECRUITING
United Hospital, Saint Paul
RECRUITING
Minnesota Oncology Hematology PA-Maplewood, Maplewood
RECRUITING
Saint John's Hospital - Healtheast, Maplewood
RECRUITING
Minnesota Oncology Hematology PA-Woodbury, Woodbury
RECRUITING
Minnesota Oncology - Burnsville, Burnsville
RECRUITING
Monticello Cancer Center, Monticello
RECRUITING
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
RECRUITING
Saint Francis Regional Medical Center, Shakopee
RECRUITING
Ridgeview Medical Center, Waconia
RECRUITING
Abbott-Northwestern Hospital, Minneapolis
RECRUITING
Hennepin County Medical Center, Minneapolis
RECRUITING
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
RECRUITING
North Memorial Medical Health Center, Robbinsdale
ACTIVE_NOT_RECRUITING
Unity Hospital, Fridley
RECRUITING
Mercy Hospital, Coon Rapids
RECRUITING
Fairview Southdale Hospital, Edina
RECRUITING
Health Partners Inc, Minneapolis
RECRUITING
Rice Memorial Hospital, Willmar
RECRUITING
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
SUSPENDED
Sanford Cancer Center Oncology Clinic, Sioux Falls
RECRUITING
Billings Clinic Cancer Center, Billings
RECRUITING
Benefis Sletten Cancer Institute, Great Falls
RECRUITING
Great Falls Clinic, Great Falls
RECRUITING
Bozeman Health Deaconess Hospital, Bozeman
RECRUITING
Saint Patrick Hospital - Community Hospital, Missoula
RECRUITING
Community Medical Center, Missoula
RECRUITING
Kalispell Regional Medical Center, Kalispell
RECRUITING
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
RECRUITING
Northwestern Medicine Cancer Center Delnor, Geneva
ACTIVE_NOT_RECRUITING
Loyola University Medical Center, Maywood
RECRUITING
Rush - Copley Medical Center, Aurora
RECRUITING
Northwestern Medicine Cancer Center Warrenville, Warrenville
RECRUITING
Northwestern University, Chicago
RECRUITING
Rush University Medical Center, Chicago
RECRUITING
University of Illinois, Chicago
RECRUITING
Illinois CancerCare-Dixon, Dixon
RECRUITING
UW Health Carbone Cancer Center Rockford, Rockford
RECRUITING
Illinois CancerCare-Ottawa Clinic, Ottawa
RECRUITING
Illinois CancerCare-Peru, Peru
RECRUITING
Valley Radiation Oncology, Peru
RECRUITING
Illinois CancerCare-Princeton, Princeton
RECRUITING
Illinois CancerCare-Galesburg, Galesburg
SUSPENDED
Western Illinois Cancer Treatment Center, Galesburg
RECRUITING
Illinois CancerCare-Kewanee Clinic, Kewanee
RECRUITING
Illinois CancerCare-Macomb, Macomb
RECRUITING
Illinois CancerCare-Canton, Canton
RECRUITING
Illinois CancerCare-Eureka, Eureka
RECRUITING
Illinois CancerCare-Pekin, Pekin
RECRUITING
Illinois CancerCare - Washington, Washington
RECRUITING
Illinois CancerCare-Peoria, Peoria
RECRUITING
Methodist Medical Center of Illinois, Peoria
RECRUITING
Illinois CancerCare-Bloomington, Bloomington
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
The Carle Foundation Hospital, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
SUSPENDED
Alton Memorial Hospital, Alton
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
HSHS Saint Elizabeth's Hospital, O'Fallon
RECRUITING
Illinois CancerCare-Carthage, Carthage
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Memorial Medical Center, Springfield
RECRUITING
Centralia Oncology Clinic, Centralia
RECRUITING
Saint Mary's Hospital, Centralia
RECRUITING
Good Samaritan Regional Health Center, Mount Vernon
RECRUITING
Memorial Hospital of Carbondale, Carbondale
RECRUITING
SIH Cancer Institute, Carterville
RECRUITING
Missouri Baptist Sullivan Hospital, Sullivan
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
BJC Outpatient Center at Sunset Hills, Sunset Hills
RECRUITING
Mercy Hospital South, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Missouri Baptist Medical Center, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
Parkland Health Center - Farmington, Farmington
RECRUITING
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
RECRUITING
Saint Francis Medical Center, Cape Girardeau
RECRUITING
Southeast Cancer Center, Cape Girardeau
RECRUITING
Heartland Regional Medical Center, Saint Joseph
RECRUITING
Freeman Health System, Joplin
RECRUITING
Mercy Hospital Joplin, Joplin
SUSPENDED
MU Health Care Goldschmidt Cancer Center, Jefferson City
RECRUITING
Delbert Day Cancer Institute at PCRMC, Rolla
RECRUITING
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
RECRUITING
Central Care Cancer Center - Bolivar, Bolivar
RECRUITING
Mercy Hospital Springfield, Springfield
RECRUITING
CoxHealth South Hospital, Springfield
RECRUITING
Central Care Cancer Center - Great Bend, Great Bend
RECRUITING
Central Care Cancer Center - Garden City, Garden City
RECRUITING
Alegent Health Immanuel Medical Center, Omaha
RECRUITING
Alegent Health Bergan Mercy Medical Center, Omaha
RECRUITING
Alegent Health Lakeside Hospital, Omaha
RECRUITING
Creighton University Medical Center, Omaha
RECRUITING
CHI Health Good Samaritan, Kearney
RECRUITING
Mercy Hospital Fort Smith, Fort Smith
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Mercy Hospital Oklahoma City, Oklahoma City
RECRUITING
UT Southwestern Clinical Center at Richardson/Plano, Richardson
RECRUITING
UT Southwestern Simmons Cancer Center - RedBird, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Tarrant County Hospital District/JPS Health Network, Fort Worth
RECRUITING
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth
ACTIVE_NOT_RECRUITING
Audie L Murphy VA Hospital, San Antonio
SUSPENDED
University of Texas Health Science Center at San Antonio, San Antonio
SUSPENDED
Littleton Adventist Hospital, Littleton
SUSPENDED
Parker Adventist Hospital, Parker
SUSPENDED
Porter Adventist Hospital, Denver
RECRUITING
Saint Anthony Hospital, Lakewood
RECRUITING
Longmont United Hospital, Longmont
RECRUITING
Penrose-Saint Francis Healthcare, Colorado Springs
RECRUITING
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
RECRUITING
Saint Francis Cancer Center, Colorado Springs
RECRUITING
Saint Mary Corwin Medical Center, Pueblo
RECRUITING
Welch Cancer Center, Sheridan
RECRUITING
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
RECRUITING
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
RECRUITING
Saint Luke's Cancer Institute - Fruitland, Fruitland
RECRUITING
Idaho Urologic Institute-Meridian, Meridian
RECRUITING
Saint Luke's Cancer Institute - Meridian, Meridian
RECRUITING
Saint Luke's Cancer Institute - Nampa, Nampa
RECRUITING
Saint Alphonsus Cancer Care Center-Nampa, Nampa
RECRUITING
Saint Alphonsus Cancer Care Center-Boise, Boise
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Kootenai Health - Coeur d'Alene, Coeur d'Alene
RECRUITING
Kootenai Clinic Cancer Services - Post Falls, Post Falls
RECRUITING
Cancer Center at Saint Joseph's, Phoenix
RECRUITING
Los Angeles General Medical Center, Los Angeles
RECRUITING
USC / Norris Comprehensive Cancer Center, Los Angeles
RECRUITING
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
City of Hope South Pasadena, South Pasadena
RECRUITING
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
RECRUITING
City of Hope Upland, Upland
RECRUITING
UC San Diego Moores Cancer Center, La Jolla
RECRUITING
City of Hope Corona, Corona
RECRUITING
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
RECRUITING
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
RECRUITING
Mission Hope Medical Oncology - Santa Maria, Santa Maria
RECRUITING
City of Hope Antelope Valley, Lancaster
SUSPENDED
Mercy Cancer Center, Merced
RECRUITING
Mercy Cancer Center - Carmichael, Carmichael
RECRUITING
Mercy San Juan Medical Center, Carmichael
RECRUITING
Woodland Memorial Hospital, Woodland
RECRUITING
Mercy Cancer Center - Elk Grove, Elk Grove
RECRUITING
Mercy Cancer Center - Rocklin, Rocklin
RECRUITING
Mercy Cancer Center - Sacramento, Sacramento
RECRUITING
Clackamas Radiation Oncology Center, Clackamas
RECRUITING
Providence Cancer Institute Clackamas Clinic, Clackamas
ACTIVE_NOT_RECRUITING
Legacy Mount Hood Medical Center, Gresham
RECRUITING
Providence Willamette Falls Medical Center, Oregon City
ACTIVE_NOT_RECRUITING
Legacy Meridian Park Hospital, Tualatin
RECRUITING
Providence Newberg Medical Center, Newberg
ACTIVE_NOT_RECRUITING
Legacy Good Samaritan Hospital and Medical Center, Portland
RECRUITING
Providence Portland Medical Center, Portland
RECRUITING
Providence Saint Vincent Medical Center, Portland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Bay Area Hospital, Coos Bay
RECRUITING
Saint Charles Health System, Bend
RECRUITING
Swedish Cancer Institute-Edmonds, Edmonds
RECRUITING
Swedish Cancer Institute-Issaquah, Issaquah
RECRUITING
Swedish Medical Center-Ballard Campus, Seattle
RECRUITING
FHCC South Lake Union, Seattle
RECRUITING
Fred Hutchinson Cancer Center, Seattle
RECRUITING
Swedish Medical Center-First Hill, Seattle
RECRUITING
FHCC at Northwest Hospital, Seattle
RECRUITING
University of Washington Medical Center - Montlake, Seattle
RECRUITING
Providence Regional Cancer Partnership, Everett
RECRUITING
PeaceHealth Saint Joseph Medical Center, Bellingham
RECRUITING
Skagit Regional Health Cancer Care Center, Mount Vernon
RECRUITING
PeaceHealth United General Medical Center, Sedro-Woolley
RECRUITING
Saint Michael Cancer Center, Silverdale
RECRUITING
Providence Regional Cancer System-Lacey, Lacey
RECRUITING
Anchorage Associates in Radiation Medicine, Anchorage
RECRUITING
Providence Regional Cancer System-Aberdeen, Aberdeen
RECRUITING
Providence Regional Cancer System-Centralia, Centralia
RECRUITING
PeaceHealth Saint John Medical Center, Longview
RECRUITING
PeaceHealth Southwest Medical Center, Vancouver
ACTIVE_NOT_RECRUITING
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver
ACTIVE_NOT_RECRUITING
Legacy Salmon Creek Hospital, Vancouver
RECRUITING
Kadlec Clinic Hematology and Oncology, Kennewick
RECRUITING
Providence Saint Mary Regional Cancer Center, Walla Walla
RECRUITING
Alaska Breast Care and Surgery LLC, Anchorage
RECRUITING
Alaska Oncology and Hematology LLC, Anchorage
RECRUITING
Alaska Women's Cancer Care, Anchorage
SUSPENDED
Anchorage Oncology Centre, Anchorage
RECRUITING
Katmai Oncology Group, Anchorage
RECRUITING
Providence Alaska Medical Center, Anchorage
ACTIVE_NOT_RECRUITING
MaineHealth Coastal Cancer Treatment Center, Bath
ACTIVE_NOT_RECRUITING
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford, Biddeford
ACTIVE_NOT_RECRUITING
Maine Medical Center-Bramhall Campus, Portland
ACTIVE_NOT_RECRUITING
MaineHealth Cancer Care Center of York County, Sanford
ACTIVE_NOT_RECRUITING
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford, Sanford
ACTIVE_NOT_RECRUITING
Maine Medical Center- Scarborough Campus, Scarborough
ACTIVE_NOT_RECRUITING
Maine Medical Partners - South Portland, South Portland
RECRUITING
Cooper Hospital University Medical Center, Camden
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Robert Wood Johnson University Hospital Somerset, Somerville
RECRUITING
Community Medical Center, Toms River
RECRUITING
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township
RECRUITING
Penn State Milton S Hershey Medical Center, Hershey
SUSPENDED
Sanford USD Medical Center - Sioux Falls, Sioux Falls
National Cancer Institute (NCI)
NIH
ECOG-ACRIN Cancer Research Group
NETWORK