Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

June 9, 2020

Primary Completion Date

April 30, 2021

Study Completion Date

April 30, 2021

Conditions
COVID-19Sars-CoV2
Interventions
BIOLOGICAL

COVID-19 Convalescent Plasma (CCP)

COVID-19 Convalescent Plasma (CCP) is a form of passive antibody therapy that involves the administration of anti-SARS-CoV-2 antibodies to a susceptible individual for the purpose of preventing or treating the infectious disease it causes. Convalescent plasma for this trial will be obtained from Vitalant (or American Red Cross if necessary). Patients identified as having recovered from COVID-19 will serve as potential donors. Potential donors will be screened using an anti-SARS-CoV-2 serologic assay and antibody levels will be determined.

BIOLOGICAL

Placebo

Standard plasma will be obtained from Vitalant (or American Red Cross if necessary) and will be either collected prior to 12/1/2019 or tested and confirmed to be negative for anti-SARS-CoV-2.

Trial Locations (3)

94110

San Francisco General Hospital, San Francisco

94115

UCSF Medical Center at Mount Zion, San Francisco

94143

University of California, San Francisco Medical Center (Parnassus Campus), San Francisco

All Listed Sponsors
collaborator

Vitalant Research Institute

OTHER

collaborator

San Francisco General Hospital

OTHER

lead

Priscilla Hsue, MD

OTHER

NCT04421404 - Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients | Biotech Hunter | Biotech Hunter