Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures

PHASE4CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

May 25, 2020

Primary Completion Date

May 30, 2021

Study Completion Date

May 31, 2021

Conditions
Ultrasonography, RenalCardiac SurgeryHemodynamicsPhenylephrineRenal PerfusionEchocardiographyAnesthesia
Interventions
DRUG

Phenylephrine

"Three time points: before, during and 20-30 minutes after infusion of phenylephrine.~Patients will receive an infusion of up to 1 mcg/kg/min phenylephrine intravenously to raise mean arterial pressure with 20 mmHg for 10 minutes. Infusion of phenylephrine will start at 0.1 mcg/kg/min with subsequent titration to effect."

OTHER

Combination of PEEP and positioning

"Six time points based on combinations of the following:~Three different levels of PEEP (as set on the ventilator): 0, 6 and 12 mmHg. Two different positions: 1) torso elevated 30 degrees, legs horizontal and 2) torso horizontal, legs elevated 30 degrees."

Trial Locations (1)

8200

Aarhus University Hospital, Department of Anaesthesiology, Aarhus

All Listed Sponsors
lead

Aarhus University Hospital

OTHER

NCT04419662 - Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures | Biotech Hunter | Biotech Hunter