Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum Disorders

NACompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

November 30, 2020

Primary Completion Date

February 2, 2023

Study Completion Date

February 2, 2023

Conditions
SchizophreniaSchizoaffective DisorderSchizophreniform Disorders
Interventions
DEVICE

Repetitive Transcranial Magnetic Stimulation

"The present study aims to use both repetitive transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS), safe and effective forms of neuromodulation, to target the neural circuitry of social cognitive (SCog) impairments in people with SSDs. Treatment sessions will be administered five days per week for two weeks.~Other Name: MagPro X100 or R30 (Medtronic A/S. Copenhagen, Denmark) equipped with a Cool-B70 A/P coil and Qooler fluid-cooling device (MagVenture, Farum, Denmark), positioned under MRI guidance using the Brainsight neuronavigation system (Rogue Resolutions, Montreal, Canada) or Localite (Localite GmbH, Bonn, Germany)"

DEVICE

Repetitive Transcranial Magnetic Stimulation (Intermittent Theta Burst Stimulation)

"The present study aims to use both repetitive transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS), safe and effective forms of neuromodulation, to target the neural circuitry of social cognitive (SCog) impairments in people with SSDs. Treatment sessions will be administered five days per week for two weeks.~Other Name: MagPro X100 or R30 (Medtronic A/S. Copenhagen, Denmark) equipped with a Cool-B70 A/P coil and Qooler fluid-cooling device (MagVenture, Farum, Denmark), positioned under MRI guidance using the Brainsight neuronavigation system (Rogue Resolutions, Montreal, Canada) or Localite (Localite GmbH, Bonn, Germany)"

DEVICE

Repetitive Transcranial Magnetic Stimulation (Sham)

Other Name: MagPro X100 or R30(Medtronic A/S. Copenhagen, Denmark) equipped with a Cool-B70 A/P coil and Qooler fluid-cooling device (MagVenture, Farum, Denmark), positioned under MRI guidance using the Brainsight neuronavigation system (Rogue Resolutions, Montreal, Canada) or Localite (Localite GmbH, Bonn, Germany)

Trial Locations (3)

11030

The Feinstein Institute for Medical Research, Manhasset

21228

Maryland Psychiatric Research Centre, Catonsville

Unknown

Centre for Addiction and Mental Health, Toronto

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Northwell Health

OTHER

collaborator

University of Maryland, Baltimore

OTHER

collaborator

National Institutes of Health (NIH)

NIH

lead

Centre for Addiction and Mental Health

OTHER

NCT04418011 - Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum Disorders | Biotech Hunter | Biotech Hunter