Adjuvant Lenvatinib Prevents Recurrence of High-risk Patients With HBV-related HCC After Liver Transplantation

CompletedOBSERVATIONAL
Enrollment

23

Participants

Timeline

Start Date

June 1, 2018

Primary Completion Date

March 31, 2020

Study Completion Date

March 31, 2020

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Lenvatinib

The patients in lenvatinib group received oral lenvatinib (Eisai, Japan) 12 mg/day (for bodyweight (BW) ≥60 kg) or 8 mg/day (for BW \<60 kg) in 28-day cycles until HCC recurrence or serious adverse events (SAEs) or voluntary withdrawal. Dose interruptions followed by reductions for lenvatinib-related toxicities (to 8 mg and 4 mg/day, or 4 mg every other day) were permitted. All 14 patients took lenvatinib for more than 3 cycles.

Trial Locations (1)

200092

Xinhua Hospital Affiliated to Shanghai Jiao Tong University Medical School, Shanghai

All Listed Sponsors
lead

Jinyang Gu

OTHER

NCT04415567 - Adjuvant Lenvatinib Prevents Recurrence of High-risk Patients With HBV-related HCC After Liver Transplantation | Biotech Hunter | Biotech Hunter