Combining Biomarkers (AFP, AFP-L3, and PIVKA-II) and Image Tools for Early Detection of Hepatocellular Carcinoma

NARecruitingINTERVENTIONAL
Enrollment

1,418

Participants

Timeline

Start Date

July 1, 2016

Primary Completion Date

June 30, 2023

Study Completion Date

February 28, 2026

Conditions
Liver CirrhosisHepatocellular CarcinomaSurveillance
Interventions
DIAGNOSTIC_TEST

AFP-L3

AFP-L3 will be tested using serum sample every 6 months.

DIAGNOSTIC_TEST

AFP

AFP will be tested using serum sample every 6 months.

DIAGNOSTIC_TEST

PIVKA-II

PIVKA-II will be tested using serum sample every 6 months.

DIAGNOSTIC_TEST

Sonography

Sonography will be tested by experts every 6 months.

DIAGNOSTIC_TEST

CT

Contrast-enhanced CT will be tested annually.

Trial Locations (15)

11765

RECRUITING

The Catholic University of Korea Uijeongbu St.Mary's Hospital, Uijeongbu-si

15355

RECRUITING

Korea University Ansan Hospital, Ansan

42601

RECRUITING

Keimyung University Dongsan Medical Center, Daegu

01757

RECRUITING

Inje University SangGye Paik Hospital, Seoul

02841

RECRUITING

Korea University Anam Hospital, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital, Seoul

04401

RECRUITING

Soonchunhyang University Seoul Hospital, Seoul

04763

RECRUITING

Hanyang University Hospital, Seoul

05030

RECRUITING

Konkuk University Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

06591

RECRUITING

The Catholic University of Korea Seoul St.Mary's Hospital, Seoul

06973

RECRUITING

Chung-Ang University Hosptial, Seoul

08308

RECRUITING

Korea University Guro Hospital, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Korea University Ansan Hospital

OTHER

collaborator

Soonchunhyang University Hospital

OTHER

collaborator

Korea University Guro Hospital

OTHER

collaborator

The Catholic University of Korea

OTHER

collaborator

Samsung Medical Center

OTHER

collaborator

Asan Medical Center

OTHER

collaborator

Korea University Anam Hospital

OTHER

collaborator

Keimyung University Dongsan Medical Center

OTHER

collaborator

Severance Hospital

OTHER

collaborator

Hanyang University

OTHER

collaborator

Konkuk University Hospital

OTHER

collaborator

Seoul National University Hospital

OTHER

collaborator

Inje University

OTHER

collaborator

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

OTHER

lead

Korea University

OTHER

NCT04414956 - Combining Biomarkers (AFP, AFP-L3, and PIVKA-II) and Image Tools for Early Detection of Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter