390
Participants
Start Date
August 5, 2020
Primary Completion Date
March 10, 2022
Study Completion Date
March 10, 2022
Unfractionated Heparin IV
Unfractionated heparin (UFH) administered intravenously with a nomogram targeting an aPTT of 1.5-2.5 times the control as per institutional therapeutic target for treatment of VTE
Enoxaparin 1 mg/kg
Enoxaparin 1 mg/kg administered subcutaneously (SC) every 12 hours
Clopidogrel
Clopidogrel 300 mg administered once orally on the day of randomization, followed by 75 mg administered once daily orally on subsequent days
Unfractionated heparin SC
Heparin 5,000 units administered subcutaneous three times daily
Enoxaparin 40 mg SC
Enoxaparin 40 mg administered subcutaneously (SC) once daily (reduce to 30 mg if CrCl\<30 ml/min)
Brigham and Women's Hospital, Boston
The TIMI Study Group
OTHER