Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients

NAActive, not recruitingINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

July 8, 2021

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2026

Conditions
Postoperative Pulmonary Complications
Interventions
PROCEDURE

Intervention group_MRA

"Tidal Volume (Vt) =6-8 mL/kg of predicted body weight (PBW), Peep=8 cmH2O, recruitment maneuvers=30cm H2O every 30 min after intubation (except during CPB), after any disconnection and at the admission in ICU.~Recruitment maneuvers are performed in accordance with the surgical team an if SAP≥90 mmHg or MAP≥65 mmHg.~Ventilation is maintained during CPB Vt=2.5 mL/kg, Peep= 5 cmH2O"

PROCEDURE

Control group

Vt=6-8 mL/kg of PBW, Peep=5 cmH2O , No recruitment maneuvers. Ventilation maintained during CPB Vt=2.5 mL/kg, Peep= 5 cmH2O.

Trial Locations (10)

Unknown

CHU Amiens-Picardie, Amiens

CHRU Brest, Brest

CHU de Dijon, Dijon

CHU de Nancy, Nancy

CHU Poitiers, Poitiers

CHU Rennes, Rennes

CHU de Rouen, Rouen

CHU Nantes, Saint-Herblain

CHU de Toulouse, Toulouse

CHRU Tours, Tours

All Listed Sponsors
lead

Rennes University Hospital

OTHER