Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

239

Participants

Timeline

Start Date

August 20, 2020

Primary Completion Date

November 18, 2025

Study Completion Date

November 18, 2025

Conditions
Diffuse Large B-cell Lymphoma
Interventions
DRUG

Brentuximab vedotin

1.2 mg/kg administered into the vein (IV; intravenously) infusion every 3 weeks

DRUG

Rituximab

375 mg/m\^2 administered via intravenous infusion on Cycle 1 Day 1. 1400 mg injected under the skin (subcutaneous) permitted every 3 weeks from Cycle 2 Day 1 through end of treatment.

DRUG

Lenalidomide

20 mg given by mouth (orally) daily

OTHER

Placebo

Administered via intravenous infusion every 3 weeks

Trial Locations (185)

100

National Taiwan University Hospital Clinical Trial Pharmacy, Taipei

National Taiwan University Hospital, Taipei

333

Chang Gung Medical Foundation, Linkou Chang Gung Memorial Hospital, Taoyuan District

704

National Cheng Kung University Hospital, Tainan City

736

Chi Mei Medical Center, Liouying, Tainan City

833

Chang Gung Medical Foundation, Kaohsiung City

2020

ZNA Middelheim, Antwerp

2030

ZNA Cadix, Antwerp

2100

Clinical Trial Unit 2081, Copenhagen

Nuklearmedicin, Copenhagen

2250

Central Coast Local Health District, Gosford Hospital, Gosford

2259

Central Coast Local Health District Wyong Hospital, Hamlyn Terrace

2650

Universitair Ziekenhuis Antwerpen, Edegem

4000

Zealand University Hospital Roskilde, Roskilde

4031

Universitatsspital Basel, Basel

5000

Royal Adelaide Hospital, Adelaide

5530

CHU UCL Namur, Yvoir

6009

Breakthrough Haematology Hollywood Specialist Centre, Nedlands

Hollywood Private Hospital, Nedlands

Hollywood Haematology, Nedlands

7000

Royal Hobart Hospital, Hobart

7100

CHU HELORA Hopital de Jolimont Pharmacie, Haine-Saint-Paul

8000

Hospitalsapoteket Region Midtjylland, Aarhus C

8091

Universitatsspital Zurich, Zurich

8200

Aarhus University Hospital, Aarhus N

8401

Kantonsspital Winterthur, Medizinische Onkologie, Winterthur

KS Winterthur Kantonsspitalapotheke, Winterthur

8952

Kantonsapotheke Zurich, Schlieren

9000

Universitair Ziekenhuis Gent, Ghent

Universitair Ziekenhuis Gent, Ghent

Aalborg University Hospital, Aalborg

Region Nordjylland, Produktion Faelles/kliniske Forsoeg, Aalborg

10005

Hospital San Pedro de Alcantara, Cáceres

Hospital San Pedro de Alcantara, Cáceres

10408

National Cancer Center, Goyang-si

11217

Pharmacy Department, Taipei Veterans General Hospital, Taipei

Taipei Veterans General Hospital, Taipei

16247

The Catholic University of Korea, Suwon

20141

Istituto Europeo di Oncologia, Milan

21201

University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore

21565

Gachon University Gil Medical Center, Incheon

22903

University of Virginia Cancer Center., Charlottesville

22908

University of Virginia Health System, Charlottesville

28010

Hospital La Milagrosa, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28046

Hospital Universitario La Paz, Madrid

Hospital Universitario La Paz, Madrid

28080

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28223

Hospital Universitario QuironSalud Madrid, Pozuelo de Alarcón

Hospital Universitario Quironsalud Madrid - Pharmacy, Pozuelo de Alarcon (madrid )

Hospital Universitario QuironSalud Madrid, Pozuelo de Alarcon (madrid)

28933

Hospital Rey Juan Carlos, Móstoles

29071

FUNDAClON GENERAL UNIVERSIDAD DE MALAGA (FGUMA), Málaga

29406

Roper St. Francis Healthcare, North Charleston

29414

Roper St. Francis Healthcare, Charleston

29464

Roper St. Francis Healthcare, Mt. Pleasant

29603

Hospital Costa Del Sol, Marbella

31008

Clinica Universidad de Navarra, Pamplona

Complejo Hospitalario de Navarra, Pamplona

Hospital de Navarra, Pamplona

32117

Florida Cancer Specialists, Daytona Beach

32960

Florida Cancer Specialists, Vero Beach

33000

Centre de Lutte Contre le Cancer (CLCC) - Institut Bergonie, Bordeaux

Centre de Lutte Contre le Cancer (CLCC) - lnstitut Bergonie Pharmacie, Bordeaux

33401

Florida Cancer Specialists, West Palm Beach

33414

Florida Cancer Specialists, Wellington

33600

Service d'Hematologie clinique et Therapie cellulaire CHU Bordeaux Hopital Haut-Leveque, Pessac

33905

Florida Cancer Specialists, Fort Myers

33908

Florida Cancer Specialists, Fort Myers

33909

Florida Cancer Specialists, Cape Coral

33980

Florida Cancer Specialists, Port Charlotte

34102

Florida Cancer Specialists, Naples

34125

Ospedale Maggiore ASUGI, Trieste

34135

Florida Cancer Specialists, Bonita Springs

34211

Florida Cancer Specialists, Bradenton

34232

Florida Cancer Specialists, Sarasota

34236

Florida Cancer Specialists, Sarasota

34285

Florida Cancer Specialists, Venice

34292

Florida Cancer Specialists, Venice

34994

Florida Cancer Specialists, Stuart

35209

Central Alabama Research, Birmingham

37000

CHRU Hopital de Tours, Tours

37004

Centro de Diagnostico y Resonancia Magnetica, Salamanca

37007

Hospital Clinico Universitario de Salamanca, Salamanca

Hospital Clínico Universitario de Salamanca, Salamanca

40138

Azienda Ospedaliero-Universitaria di Bologna - IRCCS, Bologna

42601

Keimyung University Dongsan Hospital, Daegu

45014

Oncology_Hematology Care Clinical Trials,LLC, Fairfield

45069

West Chester Hospital, West Chester

45211

Oncology_Hematology Care Clinical Trials,LLC, Cincinnati

45219

University of Cincinnati Medical Center IDS Pharmacy, Cincinnati

University of Cincinnati Medical Center, Cincinnati

45236

Oncology_Hematology Care Clinical Trials,LLC, Cincinnati

45242

Oncology_Hematology Care Clinical Trials,LLC, Cincinnati

45245

Oncology_Hematology Care Clinical Trials,LLC, Cincinnati

47392

Inje University Busan Paik Hospital, Busan

48201

Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

IP ADDRESS: Brigitte Harris Cancer Pavilion (BHCP), Detroit

48334

Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills

48377

Henry Ford Medical Center - Columbus, Novi

49201

Dong-A University Hospital., Busan

49241

Pusan National University Hospital, Busan

54907

Jeonbuk National University Hospital, Jeonju

57085

CHR Metz-Thionville Hopital Mercy, Metz

63110

Barnes Jewish-Hospital, St Louis

Washington University School of Medicine - Siteman Cancer Center, St Louis

63129

Siteman Cancer Center - South County, St Louis

63136

Siteman Cancer Center - North County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - St. Peters, City of Saint Peters

64057

MidAmerica Division, Inc. c/o Centerpoint Medical Center, Independence

64132

MidAmerica Division, Inc., c/o Research Medical Center, Kansas City

66000

Centre Hospitalier(CH) de Perpignan, Perpignan

Service Pharmacie Essais Cliniques Centre Hospitalier (CH) de Perpignan, Perpignan

66209

MidAmerica Division, Inc. c/o Menorah Medical Center, Overland Park

69310

Hôpital Lyon Sud, Pierre-Bénite

69495

"Hôpital Lyon Sud", Pierre-Bénite

70124

IRCCS Istituto Tumori Giovanni Paolo II U.O. Ematologia, Bari

72000

Centre Hospitalier Le Mans, Le Mans

73000

Centre Hospitalier Metropole Savoie, Chambéry

73039

"Azienda Ospedaliera Cardinale Giovanni Panico, U.O.C. Ematologia e Trapianti Midollo Osseo", Tricase

"Farmacia Ospedaliera Azienda Ospedaliera Cardinale Giovanni Panico", Tricase

73657

Chi Mei Hospital, Liouying, Tainan City

75012

Hopital Saint-Antoine -, Paris

75063

US Oncology Investigational Product Center (IPC), Irving

US Oncology Investigational Products Center, Irving

76038

Centre Henri Becquerel Service d'Hematologie, Rouen

Service de Radiologie ,Centre Henri Becquerel, Rouen

87042

Service d'Hematologie Clinique, Limoges

95817

University of California Davis Comprehensive Cancer Center, Sacramento

University of California Davis Medical Center, Sacramento

97401

Oncology Associates of Oregon, P.C., Eugene

Willamette Valley Cancer Institute and Research Center, Eugene

Unknown

Bellberry Limited, Eastwood

Ramsay National Research Unit and Research Governance Office, Greenslopes

Tasmania Health and Medical HREC, Hobart

A1B 3V6

Eastern Regional Health Authority, St. John's

B3H 2Y9

Queen Elizabeth II Health Science Centre, Halifax

N6A 5W9

London Health Sciences Centre, London

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

J4V 2H1

CISSS de la Monteregie-Centre, Greenfield Park

H1T 2M4

Centre Integre Universitaire de Sante et Services Sociaux de L'Est de l'lle de Montreal / installati, Montreal

H4J 1C5

Centre Integre Universitaire De Sante et de Services Sociaux Du Nord-de-I'ile-de-Montreal, Montreal

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

Lekarna Fakultni nemocnice Hradec Kralove, Hradec Králové

49933 Cedex 9

CHU Angers - Hotel Dieu Nord, Service des Maladies du Sang, Angers

91106 cedex

Centre Hospitalier Sud Francilien (CHSF), Corbeil-Essonnes

38043 Cedex 9

CHU Grenoble Alpes, Grenoble

87042 Cedex

Pharmacie a Usage lnterieur CHU de LIMOGES, Limoges

44093 Cedex 1

CHU de NANTES Hotel-Dieu Pharmacie - PTMC Rez de Jardin - Essais cliniques UPCO, Nantes

Cedex 144093

Centre Hospitalier Universitaire Nantes-Hotel Dieu, Service d'Hematologie, Nantes

06189 Cedex 2

Centre Antoine Lacassagne, Nice

33604 Cedex

Pharmacie Hopital Haut-Leveque Unite des Essais Cliniques, Pessac

76038 Cedex

Centre Henri Becquerel - Service Pharmacie, Rouen

54511 Cedex

Pharmacie Brabois - Secteur Essais Cliniques 5, Vandœuvre-lès-Nancy

Cedex 54511

CHRU de Nancy - Hopitaux de Brabois, Service Hematologie et Medecine interne, Vandœuvre-lès-Nancy

94805 Cedex

Institut Gustave Roussy Département d'Innovations Thérapeutiques et d'Essais Précoces (DITEP), Villejuif

Institut Gustave Roussy Département Pharmacie, Villejuif

Dublin 18

ICON Laboratory Services, Leopardstown

30-006

Voxel S.A., Krakow

30-510

Pratia MCM Krakow, Krakow

31-202

Zaklad Rentgena i Usg - Wyrobek Sp. z o.o. sp. k, Krakow

31-216

Zaklad Rentgena i Usg - Wyrobek Sp. z o.o. sp. k, Krakow

87-100

Nasz Lekarz Osrodek Badan Klinicznych, Torun

03722

Severance Hospital Yonsei University Health System, Seoul

04401

SoonChunHyang University Hospital Seoul, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul Saint Mary's Hospital, Seoul

08003

Hospital del Mar, Barcelona

Assaigs Clfnics-Servei de Farmacia, Barcelona

06080

Hospital Universitario de Badajoz, Badajoz

08023

Hospital Quironsalud Barcelona, Barcelona

Hospital Quiron, Barcelona

08029

CETIR, Barcelona

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08209

Hospital de la Santa Creu i Sant Pau- Pharmacy, Barcelona

08908

Institute Catala d'Oncologia_Hospital Duran i Reynals, Barcelona

B15 2TH

University Hospitals Birmingham NHS Foundation Trust, Birmingham

EC1A 7BE

Chemotherapy Production Unit (CPU), London

Dispensary Oral Drugs, London

St Bartholomew's hospital, London

SE1 9RT

Guy's and St Thomas' NHS Foundation Trust, London

All Listed Sponsors
lead

Seagen, a wholly owned subsidiary of Pfizer

INDUSTRY

NCT04404283 - Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL | Biotech Hunter | Biotech Hunter