30
Participants
Start Date
August 6, 2020
Primary Completion Date
March 26, 2024
Study Completion Date
March 26, 2024
Nocturnal polysomnography (NPSG)
Nocturnal polysomnography (NPSG) to measure REM sleep and sleep spindles characteristics.
Lumbar Puncture (LP)
Lumbar puncture (LP) to measure CSF P-Tau, T-Tau and Aβ42/40 ratio.
PET-MR measurement with a norepinephrine transporter (NET)-selective radiotracer (S,S)-[11C]Omethylreboxetine ([11C]MRB)
PET-MR measurement with a norepinephrine transporter (NET)-selective radiotracer (S,S)-\[11C\]O-methylreboxetine (\[11C\]MRB) to measure NET availability.
Psychomotor Vigilance Task (PVT)
Psychomotor vigilance task (PVT) and the OddBall to measure test taskattention performance.
NYU Grossman School of Medicine, New York
Icahn School of Medicine Mount Sinai, New York
National Institute on Aging (NIA)
NIH
NYU Langone Health
OTHER