1,033
Participants
Start Date
May 8, 2020
Primary Completion Date
July 31, 2020
Study Completion Date
July 31, 2020
Placebo
The matching Baricitinib placebo contains lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate. The coating for the placebo tablet is identical to that of the corresponding active tablet.
Remdesivir
Drug Remdesivir is a single diastereomer monophosphoramidate prodrug designed for the intracellular delivery of a modified adenine nucleoside analog GS-441524. In addition to the active ingredient, the lyophilized formulation of Remdesivir contains the following inactive ingredients: water for injection, sulfobutylether beta-cyclodextrin sodium (SBECD), and hydrochloric acid and/or sodium hydroxide.
Baricitinib
Baricitinib is a Janus kinase (JAK) inhibitor with the chemical name \[1-(ethylsulfonyl)-3-(4-(7Hpyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl\]acetonitrile Each tablet contains 2 mg of baricitinib and the following inactive ingredients: croscarmellose sodium, magnesium stearate, mannitol, microcrystalline cellulose, ferric oxide, lecithin (soya), polyethylene glycol, polyvinyl alcohol, talc and titanium dioxide.
University of Copenhagen - Centre of Excellence for Health, Immunity and Infections (CHIP) - Department of Infectious Diseases, Copenhagen
New York University School of Medicine - Langone Medical Center - Microbiology - Parasitology, New York
Seoul National University Bundang Hospital - Division of Infectious Diseases, Bundang-gu Seongnam-si
Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán - Departamento de Infectologia, Mexico City
Instituto Nacional de Enfermedades Respiratorias (INER) - Ismael Cosío Villegas, Mexico City
Penn State Health Milton S. Hershey Medical Center - Division of Infectious Diseases, Hershey
Georgetown University Medical Center - Division of Infectious Diseases, Washington D.C.
Walter Reed National Military Medical Center, Bethesda
University of Maryland School of Medicine - Center for Vaccine Development - Baltimore, Baltimore
Naval Medical Center Portsmouth - Infectious Disease Division, Portsmouth
Duke Human Vaccine Institute - Duke Vaccine and Trials Unit, Durham
Hospital Clinico San Carlos - Enfermedades Infecciosas, Madrid
Womack Army Medical Center - Pulmonary and Respiratory Services, Fort Bragg
University of California San Diego Health - Jacobs Medical Center, La Jolla
Atlanta VA Medical Center - Infectious Diseases Clinic, Decatur
University of Florida Health - Shands Hospital - Division of Infectious Diseases and Global Medicine, Gainesville
University of Miami Miller School of Medicine - Infectious Diseases, Miami
University of Alabama at Birmingham School of Medicine - Infectious Disease, Birmingham
Indiana University School of Medicine - Infectious Diseases, Indianapolis
University of Illinois at Chicago College of Medicine - Division of Infectious Diseases, Chicago
Ochsner Medical Center - Kenner - Department of Infectious Diseases, Kenner
Southeast Louisiana Veterans Health Care System (SLVHCS) - Section of Infectious Diseases, New Orleans
Baylor Scott & White Health - Baylor University Medical Center - North Texas Infectious Disease Consultants, Dallas
Brooke Army Medical Center, Fort Sam Houston
Eastern Colorado Health Care System, Aurora
Denver Health Division of Hospital Medicine - Main Campus, Denver
University of Utah - Infectious Diseases, Salt Lake City
University of New Mexico Clinical and Translational Science Center, Albuquerque
University of California Los Angeles Medical Center - Westwood Clinic, Los Angeles
Naval Medical Center San Diego - Infectious Disease Clinic, San Diego
Kaiser Permanente Northwest - Center for Health Research, Portland
EvergreenHealth Infectious Disease Service, Kirkland
Madigan Army Medical Center - Infectious Disease Clinic, Tacoma
Providence Sacred Heart Medical Center, Spokane
National University Health System - Division of Infectious Diseases, Singapore
National Centre for Infectious Diseases (NCID), Singapore
Changi General Hospital - Clinical Trials and Research Unit (CTRU), Singapore
Ng Teng Fong General Hospital - Infectious Disease Service, Singapore
University of California Irvine Medical Center - Infectious Disease, Orange
VA Palo Alto Health Care System - Infectious Diseases, Palo Alto
Stanford University - Stanford Hospital and Clinics - Pediatrics - Infectious Diseases, Palo Alto
University of California Davis Medical Center - Internal Medicine - Infectious Disease, Sacramento
University of California San Francisco - Zuckerberg San Francisco General Hospital - Division of Human Immunodeficiency Virus, Infectious Disease, and Global Medicine, San Francisco
Cedars Sinai Medical Center, West Hollywood
Emory Vaccine Center - The Hope Clinic, Decatur
Northwestern Hospital - Infectious Disease, Chicago
Johns Hopkins Hospital - Medicine - Infectious Diseases, Baltimore
National Institutes of Health - Clinical Center, National Institute of Allergy and Infectious Diseases Laboratory Of Immunoregulation, Clinical Research Section, Bethesda
Massachusetts General Hospital - Infectious Diseases, Boston
University of Massachusetts Medical School - Infectious Diseases and Immunology, Worcester
University of Minnesota Medical Center, Fairview - Infectious Diseases and International Medicine, Minneapolis
Saint Louis University - Center for Vaccine Development, St Louis
University of Nebraska Medical Center - Infectious Diseases, Omaha
University of Rochester Medical Center - Vaccine Research Unit, Rochester
Montefiore Medical Center - Infectious Diseases, The Bronx
University of Pennsylvania Perelman School of Medicine - Penn Institute for Immunology, Philadelphia
Vanderbilt University Medical Center - Infectious Diseases, Nashville
University of Texas Southwestern Medical Center - Internal Medicine - Infectious Diseases, Dallas
University of Texas Medical Branch - Division of Infectious Disease, Galveston
Baylor College of Medicine - Molecular Virology and Microbiology, Houston
University of Texas Health Science Center at San Antonio - Infectious Diseases, San Antonio
University of Virginia - Acute Care Surgery, Charlottesville
National Center for Global Health and Medicine Hospital - Disease Control and Prevention Center, Tokyo
Seoul National University Hospital, Seoul
Hospital Clinic Barcelona, Servicio de Salud Internacional, Barcelona
Hospital Germans Trias i Pujol - Servei Malalties Infeccioses, Barcelona
Royal Sussex County Hospital - Department of Intensive Care Medicine, Brighton
Saint Thomas' Hospital - Directorate of Infection, City of London
St. James's University Hospital - Infectious Diseases, Leeds
Royal Victoria Infirmary - Department of Infectious Diseases, Newcastle upon Tyne
John Radcliffe Hospital, Oxford
National Institute of Allergy and Infectious Diseases (NIAID)
NIH