10,811
Participants
Start Date
May 28, 2020
Primary Completion Date
February 5, 2025
Study Completion Date
February 5, 2025
ChAdOx1 nCoV-19 (Abs 260)
A single dose of 5x10\^10vp of ChAdOx1 nCoV-19 measured by spectrophotometry at Abs260
MenACWY vaccine
Standard single dose of MenACWY vaccine
ChAdOx1 nCoV-19 (Abs 260) + 2.2x10^10vp (qPCR) boost
A single dose of 5x10\^10vp of ChAdOx1 nCoV-19 measured by spectrophotometry at Abs260 and 2.2x10\^10vp ChAdOx1 nCoV-19 boost measured by qPCR 4-6 weeks later
Two dose MenACWY vaccine
Two standard doses of MenACWY vaccine 4-6 weeks apart
ChAdOx1 nCoV-19 (qPCR)
A single dose of 5x10\^10vp of ChAdOx1 nCoV-19 measured by qPCR
ChAdOx1 nCoV-19 0.5mL prime plus boost
Two dose ChAdOx1 nCoV-19 0.5mL (3.5 - 6.5 × 10\^10 vp Abs 260)
Two dose MenACWY vaccine min. 4 weeks apart
Two standard doses of MenACWY vaccine minimum 4 weeks apart
Two dose ChAdOx1 nCoV-19/Covishield 0.5mL
Two dose ChAdOx1 nCoV-19 0.5mL (Covishield 0.9 x 10\^11 vp/mL), 4-6 weeks apart
Two dose ChAdOx1 nCoV-19/Covishield 0.25mL & 0.5mL
Two dose ChAdOx1 nCoV-19 (Covishield 0.9 x 10\^11 vp/mL), 0.25mL prime and 0.5mL boost 4-6 weeks apart
University Hospital Southampton NHS Foundation Trust, Southampton
Castle Hill Hospital, Cottingham
St Georges University Hospital NHS Foundation Trust, London
University Hospitals Birmingham NHS Foundation Trust, Birmingham
North Bristol NHS Trust, Bristol
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol
NIHR Cambridge Clinical Research Facility, Cambridge
NHS Lothian, Western General Hospital, Edinburgh
Glasgow University and NHS Greater Glasgow & Clyde, New Lister Building, Glasgow Royal Infirmary & Queen Elizabeth University Hospital, Glasgow
Liverpool School of Tropical Medicine (LSTM), Accelerator Research Clinic. Clinical Sciences Accelerator, Liverpool
London North West University Healthcare Trust (LNWUH), Northwick Park Hospital, London
University College London Hospitals NHS Foundation Trust, London
Guy's and St Thomas' NHS Foundation Trust, Department of Infection, St Thomas Hospital, London
Imperial College Healthcare NHS Trust, London
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne
Public Health Wales, Newport
University of Nottingham Health Service, Cripps Health Centre, University Park, Nottingham
CCVTM, University of Oxford, Churchill Hospital, Oxford
John Radcliffe Hospital, Oxford
Sheffield Teaching Hospitals, Royal Hallamshire Hospital, Sheffield
University of Oxford
OTHER