Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.

NACompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

October 28, 2019

Primary Completion Date

March 12, 2020

Study Completion Date

March 12, 2020

Conditions
Pruritus
Interventions
DRUG

Desloratadine Single Dose

Desloratadine (H1-antihistamine): oral tablet (1 x 5 mg), taken with 240 ml water, 4 hours prior to the histamine skin prick

DRUG

Levocetirizine Single Dose

Levocetirizine (H1-antihistamine): oral tablet (1 x 5 mg), taken with 240 ml water, 4 hours prior to the histamine skin prick

DRUG

Desloratadine Fourfold Dose

Desloratadine (H1-antihistamine): 2 oral tablets of 5 mg in the evening and 2 oral tablets of 5 mg in the morning, taken with 240 ml water, 14 and 4 hours prior to the histamine skin prick, respectively

DRUG

Levocetirizine Fourfold Dose

Levocetirizine (H1-antihistamine): 2 oral tablets of 5 mg in the evening and 2 oral tablets of 5 mg in the morning, taken with 240 ml water, 14 and 4 hours prior to the histamine skin prick, respectively.

Trial Locations (1)

3000

Center for Clinical Pharmacology, Leuven

All Listed Sponsors
lead

Universitaire Ziekenhuizen KU Leuven

OTHER

NCT04399525 - Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin. | Biotech Hunter | Biotech Hunter